About   Help   FAQ
Npy Gene Detail
Summary
  • Symbol
    Npy
  • Name
    neuropeptide Y
  • Synonyms
    0710005A05Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:97374
    NCBI Gene: 109648
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:49799690-49806487 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 24.04 cM, cytoband B3
  • Mapping Data
    11 experiments
Strain
Comparison
more
  • SNPs within 2kb
    336 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    2
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97374
 protein coding gene Chr6:49799690-49806487 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030726
 protein coding gene Chr6:48878203-48885003 (+)
A/J MGP_AJ_G0030697
 protein coding gene Chr6:46627003-46633790 (+)
AKR/J MGP_AKRJ_G0030622
 protein coding gene Chr6:48274192-48280988 (+)
BALB/cJ MGP_BALBcJ_G0030707
 protein coding gene Chr6:46968026-46974812 (+)
C3H/HeJ MGP_C3HHeJ_G0030420
 protein coding gene Chr6:48290765-48297552 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031162
 protein coding gene Chr6:50015028-50021825 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028369
 protein coding gene Chr6:44243101-44249844 (+)
CAST/EiJ MGP_CASTEiJ_G0029824
 protein coding gene Chr6:47996834-48003648 (+)
CBA/J MGP_CBAJ_G0030395
 protein coding gene Chr6:52106278-52113065 (+)
DBA/2J MGP_DBA2J_G0030544
 protein coding gene Chr6:46539439-46546226 (+)
FVB/NJ MGP_FVBNJ_G0030496
 protein coding gene Chr6:46176138-46182925 (+)
LP/J MGP_LPJ_G0030629
 protein coding gene Chr6:48846048-48852826 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030530
 protein coding gene Chr6:54849511-54856436 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031191
 protein coding gene Chr6:48168946-48175748 (+)
PWK/PhJ MGP_PWKPhJ_G0029536
 protein coding gene Chr6:46088112-46095126 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029372
 protein coding gene Chr6:47508008-47516815 (+)
WSB/EiJ MGP_WSBEiJ_G0029901
 protein coding gene Chr6:48143507-48150311 (+)



Homology
more
  • Human Ortholog
    NPY, neuropeptide Y
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NPY, neuropeptide Y
  • Synonyms
    PYY4
  • Links
    NCBI Gene ID: 4852
    neXtProt AC: NX_P01303
    UniProt: P01303

  • Chr Location
    7p15.3; chr7:24284188-24291862 (+)  GRCh38
Human Diseases
more
  • Diseases
    11 with human NPY associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 4 alleles in 4 genetic backgrounds
    14 phenotypes from multigenic genotypes
    132 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit sporadic mild seizures and increased susceptibility to PTZ-induced seizures. Mice homozygous for a different null allele show hypoactivity and reduced exploratory behavior, an increased anxiety-related response in males, and increased defecation in females.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    54
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1246
  • Tissues
    333
  • cDNA Data
    18
  • Literature Summary
    199
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 109648 NCBI Gene Model | MGI Sequence Detail 6798 C57BL/6J ±  kb
    transcript NM_023456 RefSeq | MGI Sequence Detail 580 ZRU/MplStud  
    polypeptide P57774 UniProt | EBI | MGI Sequence Detail 97 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 40
      Genomic 1
      cDNA 20
      Primer pair 13
      Other 6

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-12928, MGI:1915648
    References
    more
    • Summaries
      All 469
      Developmental Gene Expression 199
      Gene Ontology 11
      Phenotypes 132
    • Earliest
      J:14597 Allen JM, et al., Ontogeny of a novel peptide, neuropeptide Y (NPY) in rat brain. Brain Res. 1984 Jun 11;303(1):197-200
    • Latest
      J:353900 Zhang Y, et al., Feedforward inhibition of stress by brainstem neuropeptide Y neurons. Nat Commun. 2024 Sep 1;15(1):7603
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory