Eef2 MGI Mouse Gene Detail - MGI:95288 - eukaryotic translation elongation factor 2

Symbol

Eef2
Name

eukaryotic translation elongation factor 2
Synonyms

Ef-2

Feature Type

protein coding gene
IDs

MGI:95288
NCBI Gene: 13629
Alliance

gene page
Transcription Start Sites

13 TSS

Sequence Map

Chr10:81012465-81018332 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 39.72 cM
Mapping Data

2 experiments

SNPs within 2kb

204 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_95288	protein coding gene	Chr10:81012465-81018343 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017539	protein coding gene	Chr10:81873648-81880063 (+)
A/J	MGP_AJ_G0017517	protein coding gene	Chr10:78974568-78980444 (+)
AKR/J	MGP_AKRJ_G0017478	protein coding gene	Chr10:81147443-81155301 (+)
BALB/cJ	MGP_BALBcJ_G0017479	protein coding gene	Chr10:79190823-79200911 (+)
C3H/HeJ	MGP_C3HHeJ_G0017302	protein coding gene	Chr10:81228703-81236396 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017933	protein coding gene	Chr10:84685449-84690749 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015622	protein coding gene	Chr10:75175977-75181843 (+)
CAST/EiJ	MGP_CASTEiJ_G0016869	protein coding gene	Chr10:81471294-81477600 (+)
CBA/J	MGP_CBAJ_G0017274	protein coding gene	Chr10:87976367-87984802 (+)
DBA/2J	MGP_DBA2J_G0017380	protein coding gene	Chr10:78171832-78190622 (+)
FVB/NJ	MGP_FVBNJ_G0017374	protein coding gene	Chr10:77423918-77433302 (+)
LP/J	MGP_LPJ_G0017451	protein coding gene	Chr10:82322958-82329867 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017400	protein coding gene	Chr10:89851657-89859105 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017974	protein coding gene	Chr10:81137787-81143906 (+)
PWK/PhJ	MGP_PWKPhJ_G0016650	protein coding gene	Chr10:78074761-78081411 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016440	protein coding gene	Chr10:80092792-80098666 (+)
WSB/EiJ	MGP_WSBEiJ_G0016929	protein coding gene	Chr10:81174134-81182171 (+)

Human Ortholog

EEF2, eukaryotic translation elongation factor 2

Vertebrate Orthologs

6

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

EEF2, eukaryotic translation elongation factor 2
Synonyms

EEF-2, EF-2, EF2, SCA26
Links

HGNC:3214

NCBI Gene ID: 1938

neXtProt AC: NX_P13639

UniProt: P13639
Chr Location

19p13.3; chr19:3976056-3985463 (-) GRCh38

MGI Vertebrate Homology

Eef2 stringent orthology
1 human;1 mouse;1 rat;4 zebrafish
HCOP

vertebrate homology predictions: EEF2
Gene Tree

Eef2

Diseases

3 with human EEF2 associations

				Human Disease	Mouse Models
				glaucoma IDs glaucoma DOID:1686 ICD10CM:H40 ICD9CM:365 ICD9CM:365.9 MESH:D005901 NCI:C26782 UMLS_CUI:C0017601
				spinocerebellar ataxia type 26 IDs spinocerebellar ataxia type 26 DOID:0050975 MESH:C537203 OMIM:609306
				stomach cancer IDs stomach cancer DOID:10534 DOID:10539 DOID:10542 DOID:10543 DOID:4713 ICD10CM:C16 ICD10CM:C16.2 ICD10CM:C16.5 ICD10CM:C16.6 ICD9CM:151 ICD9CM:151.4 ICD9CM:151.5 ICD9CM:151.6 ICD9CM:151.9 MESH:D013274 NCI:C3387 NCI:C9331 OMIM:613659 UMLS_CUI:C0024623 UMLS_CUI:C0038356 UMLS_CUI:C0153421 UMLS_CUI:C0153422 UMLS_CUI:C0153423

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

8 phenotypes from 1 allele in 1 genetic background
1 phenotype from multigenic genotypes
1 images
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

32
Chemically induced (other)

1
Endonuclease-mediated

4
Gene trapped

25
Targeted

2
Genomic Mutations

1 involving Eef2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

60 strains or lines available

Mice homozygous for a mutation removing the diphthamide modification display partial neonatal lethality, fetal growth retardation and abnormal cell physiology.

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All GO Annotations

51
GO References

13

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

715
Tissues

5
cDNA Data

65
Literature Summary

10

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase eef2, eef2.2

ZFIN eef2a.1, eef2b

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All Sequences

526
RefSeq

2
UniProt

20
CCDS

CCDS35993.1

Ensembl

ENSMUSG00000034994 (Evidence)
NCBI Gene

13629

			Length	Strain/Species	Flank
genomic	ENSMUSG00000034994	Ensembl Gene Model \| MGI Sequence Detail	5868	C57BL/6J	± kb
transcript	ENSMUST00000047864	Ensembl \| MGI Sequence Detail	3089	Not Applicable
polypeptide	ENSMUSP00000046101	Ensembl \| MGI Sequence Detail	858	Not Applicable

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UniProt

20 Sequences
Protein Ontology

PR:000006909 elongation factor 2

(term hierarchy)
PDB

7LS1, 7LS2
EC

3.6.5.-
InterPro Domains

IPR035647 EF-G domain III/V-like

IPR000640 Elongation factor EFG, domain V-like

IPR041095 Elongation Factor G, domain II

IPR027417 P-loop containing nucleoside triphosphate hydrolase

IPR020568 Ribosomal protein uS5 domain 2-type superfamily

IPR005225 Small GTP-binding protein domain

IPR014721 Small ribosomal subunit protein uS5 domain 2-type fold, subgroup

IPR000795 Translational (tr)-type GTP-binding domain

IPR005517 Translation elongation factor EFG/EF2, domain IV

IPR004161 Translation elongation factor EFTu-like, domain 2

IPR009000 Translation protein, beta-barrel domain superfamily

IPR031157 Tr-type G domain, conserved site
GlyGen

P58252 3 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (1 site)

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All nucleic 69

Genomic 3

cDNA 66

Microarray probesets 3

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MGD-MRK-9307, MGD-MRK-9309

Summaries

All 70

Developmental Gene Expression 10

Gene Ontology 13

Phenotypes 14
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:354580 Zhu J, et al., TNKS1BP1 mediates AECII senescence and radiation induced lung injury through suppressing EEF2 degradation. Respir Res. 2024 Aug 7;25(1):299

TSS for Eef2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr94695	Chr10:81012477-81012482 (+)	15 bp
Tssr94696	Chr10:81013527-81013571 (+)	1,084 bp
Tssr94699	Chr10:81014984-81015039 (+)	2,547 bp
Tssr94700	Chr10:81015168-81015183 (+)	2,711 bp
Tssr94701	Chr10:81015228-81015252 (+)	2,775 bp
Tssr94702	Chr10:81015405-81015417 (+)	2,946 bp
Tssr94703	Chr10:81015468-81015482 (+)	3,010 bp
Tssr94704	Chr10:81015487-81015508 (+)	3,033 bp
Tssr94705	Chr10:81015515-81015573 (+)	3,079 bp
Tssr94706	Chr10:81015707-81015741 (+)	3,259 bp
Tssr94707	Chr10:81015757-81015796 (+)	3,312 bp
Tssr94708	Chr10:81015822-81015852 (+)	3,372 bp
Tssr94709	Chr10:81016076-81016110 (+)	3,628 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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