Tnks1bp1 MGI Mouse Gene Detail - MGI:2446193 - tankyrase 1 binding protein 1

Symbol

Tnks1bp1
Name

tankyrase 1 binding protein 1
Synonyms

mKIAA1741, TAB182

Feature Type

protein coding gene
IDs

MGI:2446193
NCBI Gene: 228140
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr2:84878366-84903392 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 49.45 cM
Mapping Data

1 experiment

SNPs within 2kb

566 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2446193	protein coding gene	Chr2:84878356-84903392 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0025921	protein coding gene	Chr2:85757103-85783561 (+)
A/J	MGP_AJ_G0025895	protein coding gene	Chr2:82432898-82458478 (+)
AKR/J	MGP_AKRJ_G0025865	protein coding gene	Chr2:84566573-84591594 (+)
BALB/cJ	MGP_BALBcJ_G0025892	protein coding gene	Chr2:82563537-82589102 (+)
C3H/HeJ	MGP_C3HHeJ_G0025651	protein coding gene	Chr2:84794787-84821477 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0026338	protein coding gene	Chr2:88411090-88436094 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023740	protein coding gene	Chr2:79262135-79287207 (+)
CAST/EiJ	MGP_CASTEiJ_G0025112	protein coding gene	Chr2:85348775-85373818 (+)
CBA/J	MGP_CBAJ_G0025632	protein coding gene	Chr2:91566318-91591339 (+)
DBA/2J	MGP_DBA2J_G0025763	protein coding gene	Chr2:81969938-81995138 (+)
FVB/NJ	MGP_FVBNJ_G0025726	protein coding gene	Chr2:81227280-81252248 (+)
LP/J	MGP_LPJ_G0025851	protein coding gene	Chr2:85547362-85572393 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025756	protein coding gene	Chr2:93882515-93907584 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026394	protein coding gene	Chr2:84812481-84837509 (+)
PWK/PhJ	MGP_PWKPhJ_G0024856	protein coding gene	Chr2:81816660-81841813 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0024660	protein coding gene	Chr2:84938276-84963276 (+)
WSB/EiJ	MGP_WSBEiJ_G0025182	protein coding gene	Chr2:85474207-85499157 (+)

Human Ortholog

TNKS1BP1, tankyrase 1 binding protein 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TNKS1BP1, tankyrase 1 binding protein 1
Synonyms

CNOT12, TAB182
Links

HGNC:19081

NCBI Gene ID: 85456

neXtProt AC: NX_Q9C0C2

UniProt: Q9C0C2
Chr Location

11q12.1; chr11:57299638-57324952 (-) GRCh38

MGI Vertebrate Homology

Tnks1bp1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: TNKS1BP1
Gene Tree

Tnks1bp1

less

Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

1
Targeted

2
Genomic Mutations

3 involving Tnks1bp1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

51 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

less

All GO Annotations

30
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

53

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas

less

All Sequences

74
RefSeq

23
UniProt

4
CCDS

CCDS38166.1

Ensembl

ENSMUSG00000033955 (Evidence)
NCBI Gene

228140

			Length	Strain/Species	Flank
genomic	ENSMUSG00000033955	Ensembl Gene Model \| MGI Sequence Detail	25027	C57BL/6J	± kb
transcript	ENSMUST00000111605	Ensembl \| MGI Sequence Detail	5747	Not Applicable
polypeptide	ENSMUSP00000107232	Ensembl \| MGI Sequence Detail	1720	Not Applicable

less

UniProt

4 Sequences
Protein Ontology

PR:000016498 182 kDa tankyrase-1-binding protein

(term hierarchy)
InterPro Domains

IPR032764 Tankyrase 1-binding protein, C-terminal

IPR040006 Tankyrase 1-binding protein-like
GlyGen

P58871 3 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (2 sites)

less

All nucleic 53

cDNA 53

Microarray probesets 3

Summaries

All 35

Gene Ontology 5

Phenotypes 11
Earliest

J:82808 Strausberg RL, et al., Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903
Latest

J:354580 Zhu J, et al., TNKS1BP1 mediates AECII senescence and radiation induced lung injury through suppressing EEF2 degradation. Respir Res. 2024 Aug 7;25(1):299

TSS for Tnks1bp1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr18724	Chr2:84878365-84878437 (+)	35 bp
Tssr555	Chr2:84878534-84878572 (+)	187 bp
Tssr18725	Chr2:84878831-84878847 (+)	473 bp
Tssr18726	Chr2:84880783-84880844 (+)	2,448 bp
Tssr18727	Chr2:84891242-84891262 (+)	12,886 bp
Tssr18728	Chr2:84891281-84891304 (+)	12,927 bp
Tssr18729	Chr2:84891305-84891317 (+)	12,945 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24