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Lzts1 Gene Detail
Summary
  • Symbol
    Lzts1
  • Name
    leucine zipper, putative tumor suppressor 1
  • Synonyms
    F37, FEZ1, PSD-Zip70
  • Feature Type
    protein coding gene
  • IDs
    MGI:2684762
    NCBI Gene: 211134
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:69585321-69636877 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 33.88 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1377 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2684762
 protein coding gene Chr8:69585311-69636901 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033666
 protein coding gene Chr8:69282135-69338044 (-)
A/J MGP_AJ_G0033648
 protein coding gene Chr8:66484638-66537825 (-)
AKR/J MGP_AKRJ_G0033573
 protein coding gene Chr8:68312883-68366804 (-)
BALB/cJ MGP_BALBcJ_G0033644
 protein coding gene Chr8:66706793-66763227 (-)
C3H/HeJ MGP_C3HHeJ_G0033354
 protein coding gene Chr8:69027885-69082820 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034161
 protein coding gene Chr8:71892230-71946339 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031108
 protein coding gene Chr8:61360286-61411693 (-)
CAST/EiJ no annotation
CBA/J MGP_CBAJ_G0033332
 protein coding gene Chr8:74569769-74624126 (-)
DBA/2J MGP_DBA2J_G0033486
 protein coding gene Chr8:66198069-66252217 (-)
FVB/NJ MGP_FVBNJ_G0033427
 protein coding gene Chr8:65351339-65403663 (-)
LP/J MGP_LPJ_G0033574
 protein coding gene Chr8:69412261-69478206 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033471
 protein coding gene Chr8:77234513-77289538 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034179
 protein coding gene Chr8:68574085-68631354 (-)
PWK/PhJ MGP_PWKPhJ_G0032388
 protein coding gene Chr8:65455456-65551107 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032224
 protein coding gene Chr8:67556620-67615969 (-)
WSB/EiJ MGP_WSBEiJ_G0032796
 protein coding gene Chr8:68954332-69006690 (-)



Homology
more
  • Human Ortholog
    LZTS1, leucine zipper tumor suppressor 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LZTS1, leucine zipper tumor suppressor 1
  • Synonyms
    F37, FEZ1
  • Links
    NCBI Gene ID: 11178
    neXtProt AC: NX_Q9Y250
    UniProt: Q9Y250

  • Chr Location
    8p21.3; chr8:20246165-20303963 (-)  GRCh38
Human Diseases
more
  • Diseases
    4 with human LZTS1 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    24 phenotypes from 2 alleles in 2 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Heterozygous or homozygous inactivation of this gene leads to increased incidence of spontaneous and carcinogen-induced tumors. Homozygtes for a null allele show working memory and cognitive deficits, enhanced anxiety, defects in glutamatergic synaptic transmission, and impaired spine maturation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    776
  • Tissues
    19
  • cDNA Data
    10
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000036306 Ensembl Gene Model | MGI Sequence Detail 51557 C57BL/6J ±  kb
    transcript ENSMUST00000037049 Ensembl | MGI Sequence Detail 1800 Not Applicable  
    polypeptide ENSMUSP00000039397 Ensembl | MGI Sequence Detail 599 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 11
      cDNA 10
      Other 1

      Microarray probesets 2
    References
    more
    • Summaries
      All 36
      Developmental Gene Expression 8
      Gene Ontology 5
      Phenotypes 9
    • Earliest
      J:87418 Ishii H, et al., The FEZ1 gene at chromosome 8p22 encodes a leucine-zipper protein, and its expression is altered in multiple human tumors. Proc Natl Acad Sci U S A. 1999 Mar 30;96(7):3928-33
    • Latest
      J:353339 Butts JC, et al., A single-cell transcriptomic map of the developing Atoh1 lineage identifies neural fate decisions and neuronal diversity in the hindbrain. Dev Cell. 2024 Aug 19;59(16):2171-2188.e7
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory