Rab10 MGI Mouse Gene Detail - MGI:105066 - RAB10, member RAS oncogene family

Symbol

Rab10
Name

RAB10, member RAS oncogene family

Feature Type

protein coding gene
IDs

MGI:105066
NCBI Gene: 19325
Alliance

gene page
Transcription Start Sites

23 TSS

Sequence Map

Chr12:3297428-3359969 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 1.71 cM
Mapping Data

3 experiments

SNPs within 2kb

1013 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_105066	protein coding gene	Chr12:3297428-3359969 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0019555	protein coding gene	Chr12:19782-86705 (-)
A/J	MGP_AJ_G0019522	protein coding gene	Chr12:114351-178310 (-)
AKR/J	MGP_AKRJ_G0019492	protein coding gene	Chr12:212832-282275 (-)
BALB/cJ	MGP_BALBcJ_G0019497	protein coding gene	Chr12:106633-169049 (-)
C3H/HeJ	MGP_C3HHeJ_G0019303	protein coding gene	Chr12:15774-80215 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0019947	protein coding gene	Chr12:38418-110869 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017571	protein coding gene	Chr12:59622-116402 (-)
CAST/EiJ	MGP_CASTEiJ_G0018858	protein coding gene	Chr12:60411-125407 (-)
CBA/J	MGP_CBAJ_G0019274	protein coding gene	Chr12:239200-305341 (-)
DBA/2J	MGP_DBA2J_G0019387	protein coding gene	Chr12:66262-132201 (-)
FVB/NJ	MGP_FVBNJ_G0019378	protein coding gene	Chr12:83467-150799 (-)
LP/J	MGP_LPJ_G0019458	protein coding gene	Chr12:59516-125670 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019411	protein coding gene	Chr12:66102-138752 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019985	protein coding gene	Chr12:14153-77513 (-)
PWK/PhJ	MGP_PWKPhJ_G0018624	protein coding gene	Chr12:66333-134323 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0018415	protein coding gene	Chr12:73957-148060 (-)
WSB/EiJ	MGP_WSBEiJ_G0018910	protein coding gene	Chr12:43309-112955 (-)

Human Ortholog

RAB10, RAB10, member RAS oncogene family

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RAB10, RAB10, member RAS oncogene family
Links

HGNC:9759

NCBI Gene ID: 10890

neXtProt AC: NX_P61026

UniProt: P61026
Chr Location

2p23.3; chr2:26033285-26137454 (+) GRCh38

MGI Vertebrate Homology

Rab10 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: RAB10
Gene Tree

Rab10

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Phenotype Summary

26 phenotypes from 3 alleles in 3 genetic backgrounds
17 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

29
Endonuclease-mediated

5
Gene trapped

18
Targeted

6
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

26 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit embryonic growth and development at E7.5 with reduced cell proliferation and complete resorption by E9.5. Mice homozygous for a conditional allele activated in hepatocytes exhibit hepatic insulin resistance.

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All GO Annotations

77
GO References

17

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

715
Tissues

8
cDNA Data

25
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rab10

ZFIN rab10

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All Sequences

70
RefSeq

2
UniProt

3
CCDS

CCDS25782.1

Ensembl

ENSMUSG00000020671 (Evidence)
NCBI Gene

19325

			Length	Strain/Species	Flank
genomic	19325	NCBI Gene Model \| MGI Sequence Detail	62542	C57BL/6J	± kb
transcript	NM_016676	RefSeq \| MGI Sequence Detail	3531	ZRU/MplStud
polypeptide	P61027	UniProt \| EBI \| MGI Sequence Detail	200	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000013578 Ras-related protein Rab-10

(term hierarchy)
EC

3.6.5.2
InterPro Domains

IPR027417 P-loop containing nucleoside triphosphate hydrolase

IPR001806 Small GTPase

IPR050305 Small GTPase superfamily, Rab

IPR005225 Small GTP-binding protein domain
GlyGen

P61027 1 site, 1 O-linked glycan (1 site)

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All nucleic 29

cDNA 28

Primer pair 1

Microarray probesets 6

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MGD-MRK-32105, MGI:2145003

Summaries

All 63

Developmental Gene Expression 3

Gene Ontology 17

Phenotypes 17
Earliest

J:30578 Barbosa MD, et al., The Rab protein family: genetic mapping of six Rab genes in the mouse. Genomics. 1995 Dec 10;30(3):439-44
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Rab10:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr115599	Chr12:3359912-3359975 (-)	25 bp
Tssr115598	Chr12:3359899-3359910 (-)	64 bp
Tssr115597	Chr12:3359882-3359895 (-)	80 bp
Tssr115596	Chr12:3359840-3359851 (-)	123 bp
Tssr115595	Chr12:3359684-3359702 (-)	276 bp
Tssr115594	Chr12:3359551-3359674 (-)	356 bp
Tssr3764	Chr12:3359534-3359548 (-)	428 bp
Tssr3763	Chr12:3359529-3359530 (-)	439 bp
Tssr115593	Chr12:3359348-3359398 (-)	596 bp
Tssr115592	Chr12:3359310-3359341 (-)	643 bp
Tssr115591	Chr12:3347292-3347309 (-)	12,668 bp
Tssr115590	Chr12:3338820-3338832 (-)	21,143 bp
Tssr115589	Chr12:3314709-3314757 (-)	45,236 bp
Tssr115588	Chr12:3306968-3307009 (-)	52,980 bp
Tssr115587	Chr12:3306935-3306956 (-)	53,023 bp
Tssr115586	Chr12:3305839-3305844 (-)	54,127 bp
Tssr115585	Chr12:3303315-3303328 (-)	56,647 bp
Tssr115584	Chr12:3299746-3299828 (-)	60,182 bp
Tssr115583	Chr12:3299295-3299310 (-)	60,666 bp
Tssr115582	Chr12:3299036-3299072 (-)	60,915 bp
Tssr115581	Chr12:3298589-3298610 (-)	61,369 bp
Tssr115580	Chr12:3298308-3298332 (-)	61,649 bp
Tssr115579	Chr12:3298067-3298081 (-)	61,895 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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