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Drd2 Gene Detail
Summary
  • Symbol
    Drd2
  • Name
    dopamine receptor D2
  • Synonyms
    D2R, D2 receptor, Drd-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:94924
    NCBI Gene: 13489
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:49251927-49319477 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 26.72 cM
  • Mapping Data
    23 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2057 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    3
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_94924
 protein coding gene Chr9:49251703-49319477 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034771
 protein coding gene Chr9:48163149-48230857 (+)
A/J MGP_AJ_G0034752
 protein coding gene Chr9:46726080-46792110 (+)
AKR/J MGP_AKRJ_G0034680
 protein coding gene Chr9:47703842-47768912 (+)
BALB/cJ MGP_BALBcJ_G0034744
 protein coding gene Chr9:46445154-46514727 (+)
C3H/HeJ MGP_C3HHeJ_G0034454
 protein coding gene Chr9:48162598-48238058 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035264
 protein coding gene Chr9:49532873-49601766 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032177
 protein coding gene Chr9:46209485-46275141 (+)
CAST/EiJ MGP_CASTEiJ_G0033776
 protein coding gene Chr9:48101347-48171318 (+)
CBA/J MGP_CBAJ_G0034426
 protein coding gene Chr9:51304119-51384385 (+)
DBA/2J MGP_DBA2J_G0034585
 protein coding gene Chr9:46577975-46645408 (+)
FVB/NJ MGP_FVBNJ_G0034526
 protein coding gene Chr9:45826979-45893287 (+)
LP/J MGP_LPJ_G0034666
 protein coding gene Chr9:48544963-48612569 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034570
 protein coding gene Chr9:52960278-53033574 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035285
 protein coding gene Chr9:47657600-47723946 (+)
PWK/PhJ MGP_PWKPhJ_G0033481
 protein coding gene Chr9:46553380-46620652 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033316
 protein coding gene Chr9:47982552-48054740 (+)
WSB/EiJ MGP_WSBEiJ_G0033889
 protein coding gene Chr9:47683793-47753536 (+)



Homology
more
  • Human Ortholog
    DRD2, dopamine receptor D2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DRD2, dopamine receptor D2
  • Synonyms
    D2DR, D2R
  • Links
    NCBI Gene ID: 1813
    neXtProt AC: NX_P14416
    UniProt: P14416

  • Chr Location
    11q23.2; chr11:113409605-113475691 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with Drd2 mouse models; 14 with human DRD2 associations

Human Disease Mouse Models
      
IDs
 View 1 model
IDs
 View 1 model
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    147 phenotypes from 11 alleles in 23 genetic backgrounds
    40 phenotypes from multigenic genotypes
    248 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice show Parkinson's disease like symptoms, including akinetic and bradykinetic behavior. Mice lacking only the long isoform are hypoactive and exhibit increased sterotypic behavior in response to dopamine agonists.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    284
  • GO References
    95
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1080
  • Tissues
    205
  • cDNA Data
    16
  • Literature Summary
    57
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000032259 Ensembl Gene Model | MGI Sequence Detail 67551 C57BL/6J ±  kb
    transcript ENSMUST00000075764 Ensembl | MGI Sequence Detail 2547 Not Applicable  
    polypeptide ENSMUSP00000075170 Ensembl | MGI Sequence Detail 444 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 37
      Genomic 4
      cDNA 19
      Primer pair 8
      Other 6

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-8893, MGD-MRK-8897
    References
    more
    • Summaries
      All 499
      Developmental Gene Expression 57
      Diseases 3
      Gene Ontology 95
      Phenotypes 248
    • Earliest
      J:10932 Ratty AK, et al., Circling behavior exhibited by a transgenic insertional mutant. Brain Res Mol Brain Res. 1990 Oct;8(4):355-8
    • Latest
      J:357413 Bocarsly ME, et al., Preexisting risk-avoidance and enhanced alcohol relief are driven by imbalance of the striatal dopamine receptors in mice. Nat Commun. 2024 Oct 22;15(1):9093
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory