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Lpar1 Gene Detail
Summary
  • Symbol
    Lpar1
  • Name
    lysophosphatidic acid receptor 1
  • Synonyms
    Edg2, Gpcr26, Kdt2, LPA1, vzg-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:108429
    NCBI Gene: 14745
  • Alliance
    gene page
  • Transcription Start Sites
    16 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:58435255-58553898 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 32.20 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3271 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    4
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_108429
 protein coding gene Chr4:58435252-58554601 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028325
 protein coding gene Chr4:57267860-57391925 (-)
A/J MGP_AJ_G0028286
 protein coding gene Chr4:55080794-55202336 (-)
AKR/J MGP_AKRJ_G0028235
 protein coding gene Chr4:56607519-56732740 (-)
BALB/cJ MGP_BALBcJ_G0028305
 protein coding gene Chr4:55240006-55366361 (-)
C3H/HeJ MGP_C3HHeJ_G0028026
 protein coding gene Chr4:57100898-57229477 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028746
 protein coding gene Chr4:59282231-59416707 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026052
 protein coding gene Chr4:51849548-51963617 (-)
CAST/EiJ MGP_CASTEiJ_G0027464
 protein coding gene Chr4:56859981-56985363 (-)
CBA/J MGP_CBAJ_G0027991
 protein coding gene Chr4:61301440-61440028 (-)
DBA/2J MGP_DBA2J_G0028141
 protein coding gene Chr4:54978196-55097833 (-)
FVB/NJ MGP_FVBNJ_G0028108
 protein coding gene Chr4:54210729-54328271 (-)
LP/J MGP_LPJ_G0028240
 protein coding gene Chr4:57368969-57497417 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028132
 protein coding gene Chr4:64430845-64564679 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028782
 protein coding gene Chr4:56809914-56935975 (-)
PWK/PhJ MGP_PWKPhJ_G0027189
 protein coding gene Chr4:54992013-55118342 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027017
 protein coding gene Chr4:56099345-56231815 (-)
WSB/EiJ MGP_WSBEiJ_G0027542
 protein coding gene Chr4:56765370-56896902 (-)



Homology
more
  • Human Ortholog
    LPAR1, lysophosphatidic acid receptor 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LPAR1, lysophosphatidic acid receptor 1
  • Synonyms
    edg-2, EDG2, Gpcr26, LPA1, Mrec1.3, rec.1.3, vzg-1, VZG1
  • Links
    NCBI Gene ID: 1902
    neXtProt AC: NX_Q92633
    UniProt: Q92633

  • Chr Location
    9q31.3; chr9:110873263-111038998 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    31 phenotypes from 4 alleles in 4 genetic backgrounds
    3 images
    77 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Nullizygous mutations cause partial peri- and postnatal lethality, growth defects, craniofacial anomalies, and wide set eyes. Additional phenotypes include altered brain 5-HT and amino acids, reduced prepulse inhibition, impaired suckling, and increased apoptosis in sciatic nerve Schwann cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    77
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1323
  • Tissues
    228
  • cDNA Data
    73
  • Literature Summary
    30
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000038668 Ensembl Gene Model | MGI Sequence Detail 118644 C57BL/6J ±  kb
    transcript ENSMUST00000107571 Ensembl | MGI Sequence Detail 3543 Not Applicable  
    polypeptide ENSMUSP00000103197 Ensembl | MGI Sequence Detail 364 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 130
      Genomic 30
      cDNA 75
      Primer pair 17
      Other 8

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-26047, MGD-MRK-37473, MGI:104610, MGI:2140243
    References
    more
    • Summaries
      All 155
      Developmental Gene Expression 30
      Gene Ontology 11
      Phenotypes 77
    • Earliest
      J:26723 Thompson HA, et al., Tissue-specific expression of novel messenger ribonucleic acids cloned from a renin-expressing kidney tumor cell line (As4.1). Endocrinology. 1995 Jul;136(7):3037-45
    • Latest
      J:353367 Taketomi Y, et al., Lipid-orchestrated paracrine circuit coordinates mast cell maturation and anaphylaxis through functional interaction with fibroblasts. Immunity. 2024 Aug 13;57(8):1828-1847.e11
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory