Ube2g1 MGI Mouse Gene Detail - MGI:1914378 - ubiquitin-conjugating enzyme E2G 1

Symbol

Ube2g1
Name

ubiquitin-conjugating enzyme E2G 1
Synonyms

2700059C12Rik, D130023C12Rik

Feature Type

protein coding gene
IDs

MGI:1914378
NCBI Gene: 67128
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr11:72498109-72577307 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 44.42 cM, cytoband B4
Mapping Data

3 experiments

SNPs within 2kb

946 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1914378	protein coding gene	Chr11:72498087-72577307 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018643	protein coding gene	Chr11:73245214-73338111 (+)
A/J	MGP_AJ_G0018611	protein coding gene	Chr11:70508391-70588262 (+)
AKR/J	MGP_AKRJ_G0018580	protein coding gene	Chr11:72654503-72738083 (+)
BALB/cJ	MGP_BALBcJ_G0018583	protein coding gene	Chr11:70805330-70886427 (+)
C3H/HeJ	MGP_C3HHeJ_G0018396	protein coding gene	Chr11:72617302-72699010 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019034	protein coding gene	Chr11:75459514-75551321 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016677	protein coding gene	Chr11:67332980-67411467 (+)
CAST/EiJ	MGP_CASTEiJ_G0017951	protein coding gene	Chr11:72979098-73072595 (+)
CBA/J	MGP_CBAJ_G0018368	protein coding gene	Chr11:78826795-78918649 (+)
DBA/2J	MGP_DBA2J_G0018477	protein coding gene	Chr11:70136061-70219774 (+)
FVB/NJ	MGP_FVBNJ_G0018468	protein coding gene	Chr11:69683636-69762485 (+)
LP/J	MGP_LPJ_G0018548	protein coding gene	Chr11:73751890-73839451 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018491	protein coding gene	Chr11:79354780-79447661 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019076	protein coding gene	Chr11:72840185-72930746 (+)
PWK/PhJ	MGP_PWKPhJ_G0017724	protein coding gene	Chr11:70764809-70847303 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017514	protein coding gene	Chr11:72566270-72655394 (+)
WSB/EiJ	MGP_WSBEiJ_G0018005	protein coding gene	Chr11:72594816-72678231 (+)

Human Ortholog

UBE2G1, ubiquitin conjugating enzyme E2 G1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

UBE2G1, ubiquitin conjugating enzyme E2 G1
Synonyms

E217K, UBC7, UBE2G
Links

HGNC:12482

NCBI Gene ID: 7326

neXtProt AC: NX_P62253

UniProt: P62253
Chr Location

17p13.2; chr17:4269259-4366675 (-) GRCh38

MGI Vertebrate Homology

Ube2g1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: UBE2G1
Gene Tree

Ube2g1

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Phenotype Summary

8 phenotypes from 1 allele in 1 genetic background
23 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

144
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

136
Targeted

6
Genomic Mutations

2 involving Ube2g1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

79 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

16
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1067
Tissues

53
cDNA Data

126
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ube2g1

ZFIN ube2g1a

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All Sequences

48
RefSeq

2
UniProt

3
CCDS

CCDS36217.1

Ensembl

ENSMUSG00000020794 (Evidence)
NCBI Gene

67128

			Length	Strain/Species	Flank
genomic	ENSMUSG00000020794	Ensembl Gene Model \| MGI Sequence Detail	79199	C57BL/6J	± kb
transcript	ENSMUST00000021148	Ensembl \| MGI Sequence Detail	3815	Not Applicable
polypeptide	ENSMUSP00000021148	Ensembl \| MGI Sequence Detail	170	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000016974 ubiquitin-conjugating enzyme E2 G1

(term hierarchy)
EC

2.3.2.23
InterPro Domains

IPR050113 Ubiquitin-conjugating enzyme

IPR023313 Ubiquitin-conjugating enzyme, active site

IPR000608 Ubiquitin-conjugating enzyme E2

IPR016135 Ubiquitin-conjugating enzyme/RWD-like

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All nucleic 129

cDNA 127

Primer pair 2

Microarray probesets 3

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MGI:2144102, MGI:2144367, MGI:2144569

Summaries

All 57

Developmental Gene Expression 3

Gene Ontology 8

Phenotypes 23
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Ube2g1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr102848	Chr11:72498047-72498133 (+)	-19 bp
Tssr102849	Chr11:72498139-72498150 (+)	36 bp
Tssr102850	Chr11:72498189-72498261 (+)	116 bp
Tssr102851	Chr11:72562031-72562034 (+)	63,924 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 10/29/2024 MGI 6.24