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Ywhae Gene Detail
Summary
  • Symbol
    Ywhae
  • Name
    tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide
  • Synonyms
    14-3-3 epsilon
  • Feature Type
    protein coding gene
  • IDs
    MGI:894689
    NCBI Gene: 22627
  • Alliance
    gene page
  • Transcription Start Sites
    27 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:75623695-75656671 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 45.92 cM, cytoband B2
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    644 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_894689
 protein coding gene Chr11:75620121-75656671 (+)
129S1/SvImJ MGP_129S1SvImJ_G0018722
 protein coding gene Chr11:76505108-76542726 (+)
A/J MGP_AJ_G0018688
 protein coding gene Chr11:73655096-73688995 (+)
AKR/J MGP_AKRJ_G0018658
 protein coding gene Chr11:75890324-75923308 (+)
BALB/cJ MGP_BALBcJ_G0018662
 protein coding gene Chr11:74034023-74067163 (+)
C3H/HeJ MGP_C3HHeJ_G0018475
 protein coding gene Chr11:75900917-75936671 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019113
 protein coding gene Chr11:78925261-78961406 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016748
 protein coding gene Chr11:70667925-70703432 (+)
CAST/EiJ MGP_CASTEiJ_G0018029
 protein coding gene Chr11:76300209-76337101 (+)
CBA/J MGP_CBAJ_G0018445
 protein coding gene Chr11:82380648-82419300 (+)
DBA/2J MGP_DBA2J_G0018554
 protein coding gene Chr11:73257585-73290406 (+)
FVB/NJ MGP_FVBNJ_G0018544
 protein coding gene Chr11:72818309-72851320 (+)
LP/J MGP_LPJ_G0018625
 protein coding gene Chr11:77087177-77122706 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018570
 protein coding gene Chr11:82906416-82941829 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019153
 protein coding gene Chr11:76097282-76133073 (+)
PWK/PhJ MGP_PWKPhJ_G0017800
 protein coding gene Chr11:73965373-74000411 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017591
 protein coding gene Chr11:75656500-75690802 (+)
WSB/EiJ MGP_WSBEiJ_G0018082
 protein coding gene Chr11:75910037-75944374 (+)



Homology
more
  • Human Ortholog
    YWHAE, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    YWHAE, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon
  • Synonyms
    14-3-3E, HEL2, KCIP-1, MDCR, MDS
  • Links
    NCBI Gene ID: 7531
    neXtProt AC: NX_P62258
    UniProt: P62258

  • Chr Location
    17p13.3; chr17:1344275-1400222 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with Ywhae mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
IDs
 View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    23 phenotypes from 3 alleles in 4 genetic backgrounds
    10 phenotypes from multigenic genotypes
    38 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions of this gene usually die around birth. The small percentage of survivors are small in size and display central nervous system abnormalities including a thinner cortex and a disorganized pyramidal cell layer in the hippocampus.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    93
  • GO References
    23
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    914
  • Tissues
    173
  • cDNA Data
    14
  • Literature Summary
    16
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020849 Ensembl Gene Model | MGI Sequence Detail 32977 C57BL/6J ±  kb
    transcript ENSMUST00000067664 Ensembl | MGI Sequence Detail 2100 Not Applicable  
    polypeptide ENSMUSP00000070993 Ensembl | MGI Sequence Detail 255 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 26
      Genomic 7
      cDNA 14
      Primer pair 4
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2144388
    References
    more
    • Summaries
      All 114
      Developmental Gene Expression 16
      Diseases 2
      Gene Ontology 23
      Phenotypes 38
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:355487 Han Z, et al., The subcortical maternal complex modulates the cell cycle during early mammalian embryogenesis via 14-3-3. Nat Commun. 2024 Oct 15;15(1):8887
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    12/10/2024
    MGI 6.24     		The Jackson Laboratory