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Btg1 Gene Detail
Summary
  • Symbol
    Btg1
  • Name
    BTG anti-proliferation factor 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:88215
    NCBI Gene: 12226
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:96452868-96458671 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 49.89 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    184 from dbSNP Build 142
  • Strain Annotations
    11
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88215
 protein coding gene Chr10:96452863-96458675 (+)
129S1/SvImJ no annotation
A/J MGP_AJ_G0017653
 protein coding gene Chr10:94791440-94797255 (+)
AKR/J MGP_AKRJ_G0017613
 protein coding gene Chr10:97490278-97496387 (+)
BALB/cJ MGP_BALBcJ_G0017617
 protein coding gene Chr10:95063259-95068657 (+)
C3H/HeJ MGP_C3HHeJ_G0017440
 protein coding gene Chr10:97505690-97510457 (+)
C57BL/6NJ no annotation
CAROLI/EiJ MGP_CAROLIEiJ_G0015755
 protein coding gene Chr10:90308536-90314322 (+)
CAST/EiJ MGP_CASTEiJ_G0017003
 protein coding gene Chr10:97545299-97552729 (+)
CBA/J no annotation
DBA/2J no annotation
FVB/NJ MGP_FVBNJ_G0017508
 protein coding gene Chr10:93115468-93124808 (+)
LP/J no annotation
NOD/ShiLtJ MGP_NODShiLtJ_G0017538
 protein coding gene Chr10:106854783-106862193 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018111
 protein coding gene Chr10:97424089-97430277 (+)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0017063
 protein coding gene Chr10:97410141-97416940 (+)



Homology
more
  • Human Ortholog
    BTG1, BTG anti-proliferation factor 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    BTG1, BTG anti-proliferation factor 1
  • Synonyms
    APRO2
  • Links
    NCBI Gene ID: 694
    neXtProt AC: NX_P62324
    UniProt: P62324

  • Chr Location
    12q21.33; chr12:92140278-92145846 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    18 phenotypes from 2 alleles in 2 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit abnormal neurogenesis in the dentate gyrus, decreased proliferation and increased apoptosis in the dentate gyrus and subventricular zone, impaired spatial learning and abnormal contextual conditioning behavior.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    26
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    789
  • Tissues
    61
  • cDNA Data
    246
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000036478 Ensembl Gene Model | MGI Sequence Detail 5804 C57BL/6J ±  kb
    transcript ENSMUST00000038377 Ensembl | MGI Sequence Detail 5001 Not Applicable  
    polypeptide ENSMUSP00000038863 Ensembl | MGI Sequence Detail 171 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 251
      Genomic 1
      cDNA 247
      Primer pair 2
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-1682, MGI:2143593, MGI:2143857
    References
    more
    • Summaries
      All 62
      Developmental Gene Expression 9
      Gene Ontology 7
      Phenotypes 15
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/29/2024
    MGI 6.24     		The Jackson Laboratory