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Esrrg Gene Detail
Summary
  • Symbol
    Esrrg
  • Name
    estrogen-related receptor gamma
  • Synonyms
    ERR3, Errg, estrogen-related receptor 3, mKIAA0832, NR3B3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1347056
    NCBI Gene: 26381
  • Alliance
    gene page
  • Transcription Start Sites
    34 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:187340988-187947082 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 91.83 cM, cytoband H5
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    15136 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1347056
 protein coding gene Chr1:187340707-187947082 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016924
 protein coding gene Chr1:194431944-195066770 (+)
A/J MGP_AJ_G0016903
 protein coding gene Chr1:186471822-187083010 (+)
AKR/J MGP_AKRJ_G0016868
 protein coding gene Chr1:191965681-192596771 (+)
BALB/cJ MGP_BALBcJ_G0016861
 protein coding gene Chr1:187151609-187772382 (+)
C3H/HeJ MGP_C3HHeJ_G0016685
 protein coding gene Chr1:192830164-193460968 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017324
 protein coding gene Chr1:200643922-201306863 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015031
 protein coding gene Chr1:177450623-178056712 (+)
CAST/EiJ MGP_CASTEiJ_G0016268
 protein coding gene Chr1:192346371-193012638 (+)
CBA/J MGP_CBAJ_G0016659
 protein coding gene Chr1:208116501-208795535 (+)
DBA/2J MGP_DBA2J_G0016765
 protein coding gene Chr1:185230071-185847951 (+)
FVB/NJ MGP_FVBNJ_G0016761
 protein coding gene Chr1:183332541-183949476 (+)
LP/J MGP_LPJ_G0016840
 protein coding gene Chr1:195604456-196245067 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016793
 protein coding gene Chr1:214917911-215580032 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017361
 protein coding gene Chr1:191877108-192509196 (+)
PWK/PhJ MGP_PWKPhJ_G0016055
 protein coding gene Chr1:184452993-185083006 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015831
 protein coding gene Chr1:190827049-191470708 (+)
WSB/EiJ MGP_WSBEiJ_G0016330
 protein coding gene Chr1:192046197-192692633 (+)



Homology
more
  • Human Ortholog
    ESRRG, estrogen related receptor gamma
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ESRRG, estrogen related receptor gamma
  • Synonyms
    ERR3, ERRg, ERR-gamma, ERRgamma, NR3B3
  • Links
    NCBI Gene ID: 2104
    neXtProt AC: NX_P62508
    UniProt: P62508

  • Chr Location
    1q41; chr1:216503246-217137755 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    23 phenotypes from 3 alleles in 5 genetic backgrounds
    35 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Nullizygous mutations lead to postnatal lethality. Homozygotes for a null allele show reduced birth weight, fasting hyperlactatemia, altered electrocardiograms and mitochondrial function, and agenesis of the renal papilla. Surviving homozygotes for a different null allele exhibit hearing loss.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    30
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1320
  • Tissues
    358
  • cDNA Data
    16
  • Literature Summary
    38
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000026610 Ensembl Gene Model | MGI Sequence Detail 606095 C57BL/6J ±  kb
    transcript ENSMUST00000027906 Ensembl | MGI Sequence Detail 5293 Not Applicable  
    polypeptide ENSMUSP00000027906 Ensembl | MGI Sequence Detail 458 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 25
      cDNA 17
      Primer pair 6
      Other 2

      Microarray probesets 3
    References
    more
    • Summaries
      All 127
      Developmental Gene Expression 38
      Gene Ontology 11
      Phenotypes 35
    • Earliest
      J:56623 Hong H, et al., Hormone-independent transcriptional activation and coactivator binding by novel orphan nuclear receptor ERR3. J Biol Chem. 1999 Aug 6;274(32):22618-26
    • Latest
      J:349437 Adkins-Threats M, et al., Metabolic regulator ERRgamma governs gastric stem cell differentiation into acid-secreting parietal cells. Cell Stem Cell. 2024 May 7;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory