Ybx1 MGI Mouse Gene Detail - MGI:99146

Symbol

Ybx1
Name

Y box protein 1
Synonyms

dbpB, DNA binding protein B, EF1A, MSY1, Nsep1, YB-1

Feature Type

protein coding gene
IDs

MGI:99146
NCBI Gene: 22608
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr4:119135178-119151801 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 55.34 cM, cytoband D1
Mapping Data

3 experiments

SNPs within 2kb

407 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_99146	protein coding gene	Chr4:119134524-119153462 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0028695	protein coding gene	Chr4:120465575-120483438 (-)
A/J	MGP_AJ_G0028655	protein coding gene	Chr4:115731260-115749302 (-)
AKR/J	MGP_AKRJ_G0028608	protein coding gene	Chr4:118241569-118259135 (-)
BALB/cJ	MGP_BALBcJ_G0028678	protein coding gene	Chr4:116349822-116366917 (-)
C3H/HeJ	MGP_C3HHeJ_G0028393	protein coding gene	Chr4:119808191-119827992 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0029119	protein coding gene	Chr4:125039943-125056501 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026396	protein coding gene	Chr4:109834148-109850703 (-)
CAST/EiJ	MGP_CASTEiJ_G0027824	protein coding gene	Chr4:117131995-117152454 (-)
CBA/J	MGP_CBAJ_G0028360	protein coding gene	Chr4:128419623-128436478 (-)
DBA/2J	MGP_DBA2J_G0028507	protein coding gene	Chr4:116323954-116340771 (-)
FVB/NJ	MGP_FVBNJ_G0028473	protein coding gene	Chr4:114838553-114858510 (-)
LP/J	MGP_LPJ_G0028607	protein coding gene	Chr4:120583688-120599898 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028501	protein coding gene	Chr4:133286501-133303783 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029156	protein coding gene	Chr4:119320146-119336610 (-)
PWK/PhJ	MGP_PWKPhJ_G0027547	protein coding gene	Chr4:113245751-113264063 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0027373	protein coding gene	Chr4:115731518-115754801 (-)
WSB/EiJ	MGP_WSBEiJ_G0027904	protein coding gene	Chr4:119323511-119339945 (-)

Human Ortholog

YBX1, Y-box binding protein 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

YBX1, Y-box binding protein 1
Synonyms

BP-8, CBF-A, CSDA2, CSDB, DBPB, EFI-A, MDR-NF1, NSEP-1, NSEP1, YB-1, YB1
Links

HGNC:8014

NCBI Gene ID: 4904

neXtProt AC: NX_P67809

UniProt: P67809
Chr Location

1p34.2; chr1:42682418-42703805 (+) GRCh38

MGI Vertebrate Homology

Ybx1 stringent orthology
1 human;1 mouse;2 rat;1 zebrafish
HCOP

vertebrate homology predictions: YBX1
Gene Tree

Ybx1

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Phenotype Summary

27 phenotypes from 3 alleles in 4 genetic backgrounds
5 phenotypes from multigenic genotypes
2 images
23 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

25
Chemically induced (other)

2
Endonuclease-mediated

3
Gene trapped

14
Radiation induced

1
Targeted

5
Genomic Mutations

4 involving Ybx1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

19 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice exhibit embryonic and perinatal lethality and are severely growth retarded. Some mice exhibit craniofacial defects and respiratory failure. MEFs are more sensitive to oxidative stress resulting in premature senescence.

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All GO Annotations

92
GO References

22

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

888
Tissues

102
cDNA Data

516
Literature Summary

16

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA YBX1

Xenbase ybx1

ZFIN ybx1

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All Sequences

100
RefSeq

8
UniProt

8
CCDS

CCDS18579.1

Ensembl

ENSMUSG00000028639 (Evidence)
NCBI Gene

22608

			Length	Strain/Species	Flank
genomic	ENSMUSG00000028639	Ensembl Gene Model \| MGI Sequence Detail	16624	C57BL/6J	± kb
transcript	ENSMUST00000079644	Ensembl \| MGI Sequence Detail	1628	Not Applicable
polypeptide	ENSMUSP00000078589	Ensembl \| MGI Sequence Detail	322	Not Applicable

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UniProt

8 Sequences
Protein Ontology

PR:000017525 Y-box-binding protein 1

(term hierarchy)
InterPro Domains

IPR019844 Cold-shock (CSD) domain

IPR011129 Cold shock domain

IPR050181 Cold shock domain-containing protein

IPR002059 Cold-shock protein, DNA-binding

IPR012340 Nucleic acid-binding, OB-fold
GlyGen

P62960 1 site, 1 O-linked glycan (1 site)

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All nucleic 530

cDNA 518

Primer pair 8

Other 4

Microarray probesets 6

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MGD-MRK-15843, MGI:2140677

Summaries

All 112

Developmental Gene Expression 16

Gene Ontology 22

Phenotypes 23
Earliest

J:1387 Shaughnessy M, et al., Absence of MHC gene expression in lens and cloning of dbpB/YB-1, a DNA-binding protein expressed in mouse lens. Curr Eye Res. 1992 Feb;11(2):175-81
Latest

J:343217 Sanchez BJ, et al., The formation of HuR/YB1 complex is required for the stabilization of target mRNA to promote myogenesis. Nucleic Acids Res. 2023 Feb 22;51(3):1375-1392

TSS for Ybx1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr43106	Chr4:119151941-119151950 (-)	-145 bp
Tssr43105	Chr4:119151911-119151922 (-)	-116 bp
Tssr43104	Chr4:119151717-119151735 (-)	75 bp
Tssr43103	Chr4:119151697-119151715 (-)	95 bp
Tssr43102	Chr4:119151644-119151667 (-)	145 bp
Tssr43101	Chr4:119151597-119151642 (-)	181 bp
Tssr43100	Chr4:119151435-119151507 (-)	330 bp
Tssr43099	Chr4:119139450-119139477 (-)	12,337 bp
Tssr43098	Chr4:119136303-119136317 (-)	15,491 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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