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Cyth2 Gene Detail
Summary
  • Symbol
    Cyth2
  • Name
    cytohesin 2
  • Synonyms
    ARNO, CLM2, Pscd2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1334255
    NCBI Gene: 19158
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:45456058-45463857 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 29.52 cM, cytoband B3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    229 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1334255
 protein coding gene Chr7:45456058-45464005 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032248
 protein coding gene Chr7:46127817-46135760 (-)
A/J MGP_AJ_G0032227
 protein coding gene Chr7:45206526-45213461 (-)
AKR/J MGP_AKRJ_G0032163
 protein coding gene Chr7:46475711-46483655 (-)
BALB/cJ MGP_BALBcJ_G0032239
 protein coding gene Chr7:45204522-45211455 (-)
C3H/HeJ MGP_C3HHeJ_G0031954
 protein coding gene Chr7:46958385-46966321 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032731
 protein coding gene Chr7:48388756-48395698 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029745
 protein coding gene Chr7:47756928-47763917 (-)
CAST/EiJ MGP_CASTEiJ_G0031282
 protein coding gene Chr7:38403917-38411855 (-)
CBA/J MGP_CBAJ_G0031919
 protein coding gene Chr7:50011552-50018494 (-)
DBA/2J MGP_DBA2J_G0032077
 protein coding gene Chr7:44883817-44891753 (-)
FVB/NJ MGP_FVBNJ_G0032028
 protein coding gene Chr7:44661037-44667979 (-)
LP/J MGP_LPJ_G0032155
 protein coding gene Chr7:46832804-46839736 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032065
 protein coding gene Chr7:48676750-48684698 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032747
 protein coding gene Chr7:45682475-45689408 (-)
PWK/PhJ MGP_PWKPhJ_G0031005
 protein coding gene Chr7:38256448-38263385 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030843
 protein coding gene Chr7:33712874-33719887 (-)
WSB/EiJ MGP_WSBEiJ_G0031400
 protein coding gene Chr7:46178241-46185175 (-)



Homology
more
  • Human Ortholog
    CYTH2, cytohesin 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CYTH2, cytohesin 2
  • Synonyms
    ARNO, CTS18, CTS18.1, cytohesin-2, PSCD2, PSCD2L, SEC7L, Sec7p-L, Sec7p-like
  • Links
    NCBI Gene ID: 9266
    neXtProt AC: NX_Q99418
    UniProt: Q99418

  • Chr Location
    19q13.33; chr19:48469208-48482314 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a conditional allele activated in Schwann cell exhibit reduced sciatic nerve myelin sheath thickness. Mice homozygous for a null allele exhibit reduced eosinophilic infiltration into the septum an ovalbumin-induced model of murine rhinitis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    20
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    708
  • Tissues
    2
  • cDNA Data
    99
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 19158 NCBI Gene Model | MGI Sequence Detail 7800 C57BL/6J ±  kb
transcript NR_175963 RefSeq | MGI Sequence Detail 3908 C57BL/6  
polypeptide P63034 UniProt | EBI | MGI Sequence Detail 400 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 101
    cDNA 100
    Primer pair 1

    Microarray probesets 3
References
more
  • Summaries
    All 49
    Developmental Gene Expression 1
    Gene Ontology 12
    Phenotypes 11
  • Earliest
    J:49556 Kim HS, et al., Complex regulation of multiple cytohesin-like genes in murine tissues and cells. FEBS Lett. 1998 Aug 21;433(3):312-6
  • Latest
    J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory