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Kcnab1 Gene Detail
Summary
  • Symbol
    Kcnab1
  • Name
    potassium voltage-gated channel, shaker-related subfamily, beta member 1
  • Synonyms
    Akr8a8, Kvbeta1.1, mKv(beta)1
  • Feature Type
    protein coding gene
  • IDs
    MGI:109155
    NCBI Gene: 16497
  • Alliance
    gene page
  • Transcription Start Sites
    17 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:64856636-65285643 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 30.15 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    12163 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109155
 protein coding gene Chr3:64856617-65285644 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027270
 protein coding gene Chr3:64210072-64490726 (+)
A/J MGP_AJ_G0027231
 protein coding gene Chr3:62351309-62620387 (+)
AKR/J MGP_AKRJ_G0027200
 protein coding gene Chr3:63630946-63897261 (+)
BALB/cJ MGP_BALBcJ_G0027243
 protein coding gene Chr3:62178961-62440430 (+)
C3H/HeJ MGP_C3HHeJ_G0026987
 protein coding gene Chr3:63910961-64190569 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027689
 protein coding gene Chr3:66642014-66923374 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025042
 protein coding gene Chr3:58746208-59019076 (+)
CAST/EiJ MGP_CASTEiJ_G0026434
 protein coding gene Chr3:63854151-64134059 (+)
CBA/J MGP_CBAJ_G0026962
 protein coding gene Chr3:68724869-68995380 (+)
DBA/2J MGP_DBA2J_G0027098
 protein coding gene Chr3:61842803-62118769 (+)
FVB/NJ MGP_FVBNJ_G0027066
 protein coding gene Chr3:60500437-60762817 (+)
LP/J MGP_LPJ_G0027206
 protein coding gene Chr3:65133041-65407759 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027084
 protein coding gene Chr3:73309882-73600621 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027747
 protein coding gene Chr3:63532662-63806209 (+)
PWK/PhJ MGP_PWKPhJ_G0026168
 protein coding gene Chr3:61599200-61865257 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025984
 protein coding gene Chr3:62731648-63015152 (+)
WSB/EiJ MGP_WSBEiJ_G0026512
 protein coding gene Chr3:63662113-63937931 (+)



Homology
more
  • Human Ortholog
    KCNAB1, potassium voltage-gated channel subfamily A regulatory beta subunit 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KCNAB1, potassium voltage-gated channel subfamily A regulatory beta subunit 1
  • Synonyms
    AKR6A3, hKvb3, hKvBeta3, KCNA1B, Kvb1.3, KV-BETA-1
  • Links
    NCBI Gene ID: 7881
    neXtProt AC: NX_Q14722
    UniProt: Q14722

  • Chr Location
    3q25.31; chr3:156037701-156539138 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human KCNAB1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 3 alleles in 4 genetic backgrounds
    1 phenotype from multigenic genotypes
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene experience some learning defects but are otherwise normal.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    44
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    777
  • Tissues
    56
  • cDNA Data
    22
  • Literature Summary
    10
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 16497 NCBI Gene Model | MGI Sequence Detail 429008 C57BL/6J ±  kb
transcript NM_010597 RefSeq | MGI Sequence Detail 3597 ZRU/MplStud  
polypeptide P63143 UniProt | EBI | MGI Sequence Detail 401 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000009251 voltage-gated potassium channel subunit beta-1
    (term hierarchy)
  • EC
    1.1.1.-
  • InterPro Domains
    IPR023210 NADP-dependent oxidoreductase domain
    IPR036812 NADP-dependent oxidoreductase domain superfamily
    IPR005983 Potassium channel, voltage-dependent, beta subunit, KCNAB
    IPR005400 Potassium channel, voltage-dependent, beta subunit, KCNAB1
    IPR005399 Potassium channel, voltage-dependent, beta subunit, KCNAB-related
  • GlyGen
    P63143 1 site, 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 24
    cDNA 23
    Primer pair 1

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-38199
References
more
  • Summaries
    All 54
    Developmental Gene Expression 10
    Diseases 1
    Gene Ontology 10
    Phenotypes 14
  • Earliest
    J:36040 Fink M, et al., A new K+ channel beta subunit to specifically enhance Kv2.2 (CDRK) expression. J Biol Chem. 1996 Oct 18;271(42):26341-8
  • Latest
    J:348859 Lee Y, et al., Transcriptional control of motor pool formation and motor circuit connectivity by the LIM-HD protein Isl2. Elife. 2023 Oct 23;12
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory