Tubb4b MGI Mouse Gene Detail - MGI:1915472 - tubulin, beta 4B class IVB

Symbol

Tubb4b
Name

tubulin, beta 4B class IVB
Synonyms

4930542G03Rik, MGC:28623, MGC:6713, Tubb2c

Feature Type

protein coding gene
IDs

MGI:1915472
NCBI Gene: 227613
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr2:25112172-25114714 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 17.08 cM, cytoband A3
Mapping Data

3 experiments

SNPs within 2kb

80 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1915472	protein coding gene	Chr2:25112170-25114714 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0025426	protein coding gene	Chr2:23087360-23091108 (-)
A/J	MGP_AJ_G0025403	protein coding gene	Chr2:22199280-22200411 (-)
AKR/J	MGP_AKRJ_G0025373	protein coding gene	Chr2:22941505-22945938 (-)
BALB/cJ	MGP_BALBcJ_G0025399	protein coding gene	Chr2:22309917-22313458 (-)
C3H/HeJ	MGP_C3HHeJ_G0025160	protein coding gene	Chr2:22870729-22873244 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0025843	protein coding gene	Chr2:23819925-23823971 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023254	protein coding gene	Chr2:21119542-21122076 (-)
CAST/EiJ	MGP_CASTEiJ_G0024623	protein coding gene	Chr2:22754450-22756708 (-)
CBA/J	MGP_CBAJ_G0025138	protein coding gene	Chr2:24658608-24660877 (-)
DBA/2J	MGP_DBA2J_G0025271	protein coding gene	Chr2:22043466-22045644 (-)
FVB/NJ	MGP_FVBNJ_G0025233	protein coding gene	Chr2:21782959-21785503 (-)
LP/J	MGP_LPJ_G0025357	protein coding gene	Chr2:23032323-23035274 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025264	protein coding gene	Chr2:24860972-24863716 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025902	protein coding gene	Chr2:22887743-22890541 (-)
PWK/PhJ	MGP_PWKPhJ_G0024371	protein coding gene	Chr2:21856795-21857925 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0024171	protein coding gene	Chr2:23044828-23048113 (-)
WSB/EiJ	MGP_WSBEiJ_G0024692	protein coding gene	Chr2:22962448-22963579 (-)

Human Ortholog

TUBB4B, tubulin beta 4B class IVb

Vertebrate Orthologs

5

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TUBB4B, tubulin beta 4B class IVb
Synonyms

Beta2, LCAEOD, TUBB2, TUBB2C
Links

HGNC:20771

NCBI Gene ID: 10383

neXtProt AC: NX_P68371

UniProt: P68371
Chr Location

9q34.3; chr9:137241287-137243707 (+) GRCh38

MGI Vertebrate Homology

Tubb4b stringent orthology
1 human;1 mouse;1 rat;3 zebrafish
HCOP

vertebrate homology predictions: TUBB4B
Gene Tree

Tubb4b

Diseases

1 with human TUBB4B associations

				Human Disease	Mouse Models
				Leber congenital amaurosis with early-onset deafness IDs Leber congenital amaurosis with early-onset deafness DOID:0112240 OMIM:617879

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

10 phenotypes from 2 alleles in 2 genetic backgrounds
1 phenotype from multigenic genotypes
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

20
Endonuclease-mediated

2
Gene trapped

14
Targeted

4
Find Mice (IMSR)

18 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele display partial postnatal lethality and severe truncation of cilia on multi-ciliated cells.

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All GO Annotations

25
GO References

12

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

729
Tissues

22
cDNA Data

13
Literature Summary

34

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tubb4b

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All Sequences

49
RefSeq

2
UniProt

3
CCDS

CCDS15753.1

Ensembl

ENSMUSG00000036752 (Evidence)
NCBI Gene

227613

			Length	Strain/Species	Flank
genomic	ENSMUSG00000036752	Ensembl Gene Model \| MGI Sequence Detail	2543	C57BL/6J	± kb
transcript	ENSMUST00000043584	Ensembl \| MGI Sequence Detail	1598	Not Applicable
polypeptide	ENSMUSP00000042342	Ensembl \| MGI Sequence Detail	445	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000016818 tubulin beta-4B chain

(term hierarchy)
PDB

8I7O, 8I7R, 8IYJ, 8TO0
InterPro Domains

IPR002453 Beta tubulin

IPR013838 Beta tubulin, autoregulation binding site

IPR000217 Tubulin

IPR017975 Tubulin, conserved site

IPR023123 Tubulin, C-terminal

IPR018316 Tubulin/FtsZ, 2-layer sandwich domain

IPR008280 Tubulin/FtsZ, C-terminal

IPR003008 Tubulin/FtsZ, GTPase domain

IPR036525 Tubulin/FtsZ, GTPase domain superfamily

IPR037103 Tubulin/FtsZ-like, C-terminal domain
GlyGen

P68372 2 sites, 1 O-linked glycan (2 sites)

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All nucleic 15

cDNA 14

Primer pair 1

Microarray probesets 7

Summaries

All 80

Developmental Gene Expression 34

Gene Ontology 12

Phenotypes 10
Earliest

J:35227 Wang D, et al., The mammalian beta-tubulin repertoire: hematopoietic expression of a novel, heterologous beta-tubulin isotype. J Cell Biol. 1986 Nov;103(5):1903-10
Latest

J:354352 Sanzhaeva U, et al., TUBB4B is essential for the expansion of differentiating spermatogonia. Sci Rep. 2024 Sep 7;14(1):20889

TSS for Tubb4b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr22950	Chr2:25114665-25114671 (-)	46 bp
Tssr22949	Chr2:25114242-25114280 (-)	453 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 10/22/2024 MGI 6.24