Hes5 MGI Mouse Gene Detail - MGI:104876 - hes family bHLH transcription factor 5

Symbol

Hes5
Name

hes family bHLH transcription factor 5
Synonyms

bHLHb38

Feature Type

protein coding gene
IDs

MGI:104876
NCBI Gene: 15208
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr4:155045380-155046828 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 86.01 cM
Mapping Data

3 experiments

SNPs within 2kb

91 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_104876	protein coding gene	Chr4:155042358-155046829 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0029203	protein coding gene	Chr4:159247868-159249316 (+)
A/J	MGP_AJ_G0029168	protein coding gene	Chr4:152564590-152566038 (+)
AKR/J	MGP_AKRJ_G0029116	protein coding gene	Chr4:156724476-156725924 (+)
BALB/cJ	MGP_BALBcJ_G0029184	protein coding gene	Chr4:153038481-153039929 (+)
C3H/HeJ	MGP_C3HHeJ_G0028905	protein coding gene	Chr4:157258182-157259630 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0029633	protein coding gene	Chr4:164942249-164943697 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026879	protein coding gene	Chr4:144865790-144867230 (+)
CAST/EiJ	MGP_CASTEiJ_G0028318	protein coding gene	Chr4:154689830-154691278 (+)
CBA/J	MGP_CBAJ_G0028867	protein coding gene	Chr4:169881979-169883427 (+)
DBA/2J	MGP_DBA2J_G0029016	protein coding gene	Chr4:152588887-152590335 (+)
FVB/NJ	MGP_FVBNJ_G0028980	protein coding gene	Chr4:151811046-151812494 (+)
LP/J	MGP_LPJ_G0029106	protein coding gene	Chr4:159168598-159170046 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029007	protein coding gene	Chr4:172757419-172758867 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029665	protein coding gene	Chr4:157321015-157322463 (+)
PWK/PhJ	MGP_PWKPhJ_G0028038	protein coding gene	Chr4:148710292-148711745 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0027872	protein coding gene	Chr4:151596814-151598268 (+)
WSB/EiJ	MGP_WSBEiJ_G0028398	protein coding gene	Chr4:157481219-157482667 (+)

Human Ortholog

HES5, hes family bHLH transcription factor 5

Vertebrate Orthologs

10

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

HES5, hes family bHLH transcription factor 5
Synonyms

bHLHb38
Links

HGNC:19764

NCBI Gene ID: 388585

neXtProt AC: NX_Q5TA89

UniProt: Q5TA89
Chr Location

1p36.32; chr1:2528745-2530263 (-) GRCh38

MGI Vertebrate Homology

Hes5 stringent orthology
1 human;1 mouse;1 rat;8 zebrafish
HCOP

vertebrate homology predictions: HES5
Gene Tree

Hes5

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Phenotype Summary

8 phenotypes from 1 allele in 1 genetic background
33 phenotypes from multigenic genotypes
52 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Targeted

10
Transgenic

2
Genomic Mutations

3 involving Hes5
Incidental Mutations

CvDC
Find Mice (IMSR)

16 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for disruptions in this gene are phenotypically normal although there are subtile histological abnormalities associated with sensory organs.

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All GO Annotations

101
GO References

29

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1506
Tissues

352
cDNA Data

26
Literature Summary

350

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

GEISHA HES5A

Xenbase hes5, hes5.2, hes5.3, hes5.4, hes5.5, hes5.7, hes5.9

ZFIN her2, her4.1

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All Sequences

44
RefSeq

6
UniProt

3
CCDS

CCDS19018.1

Ensembl

ENSMUSG00000048001 (Evidence)
NCBI Gene

15208

			Length	Strain/Species	Flank
genomic	ENSMUSG00000048001	Ensembl Gene Model \| MGI Sequence Detail	1449	C57BL/6J	± kb
transcript	ENSMUST00000049621	Ensembl \| MGI Sequence Detail	1273	Not Applicable
polypeptide	ENSMUSP00000051118	Ensembl \| MGI Sequence Detail	167	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000008519 transcription factor HES-5

(term hierarchy)
InterPro Domains

IPR050370 Hairy and Enhancer of Split/HEY-related

IPR036638 Helix-loop-helix DNA-binding domain superfamily

IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain

IPR003650 Orange domain

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All nucleic 91

cDNA 39

Primer pair 19

Other 33

Microarray probesets 3

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MGD-MRK-28176

Summaries

All 423

Developmental Gene Expression 350

Gene Ontology 29

Phenotypes 52
Earliest

J:71335 Akazawa C, et al., Molecular characterization of a rat negative regulator with a basic helix-loop-helix structure predominantly expressed in the developing nervous system. J Biol Chem. 1992 Oct 25;267(30):21879-85
Latest

J:357284 Lo Giudice Q, et al., Developmental emergence of first- and higher-order thalamic neuron molecular identities. Development. 2024 Sep 15;151(18)

TSS for Hes5:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr40612	Chr4:155045372-155045387 (+)	0 bp
Tssr40613	Chr4:155045457-155045474 (+)	86 bp
Tssr40614	Chr4:155045634-155045646 (+)	260 bp
Tssr40615	Chr4:155045855-155045875 (+)	485 bp
Tssr40616	Chr4:155045920-155045931 (+)	546 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24