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Pkn1 Gene Detail
Summary
  • Symbol
    Pkn1
  • Name
    protein kinase N1
  • Synonyms
    F730027O18Rik, PAK1, Pkn, PRK1, Prkcl1, Stk3
  • Feature Type
    protein coding gene
  • IDs
    MGI:108022
    NCBI Gene: 320795
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:84393165-84425808 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 40.22 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    682 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_108022
 protein coding gene Chr8:84393162-84425819 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033838
 protein coding gene Chr8:84509266-84542294 (-)
A/J MGP_AJ_G0033821
 protein coding gene Chr8:81209735-81239089 (-)
AKR/J MGP_AKRJ_G0033747
 protein coding gene Chr8:83599164-83631300 (-)
BALB/cJ MGP_BALBcJ_G0033814
 protein coding gene Chr8:81306583-81338979 (-)
C3H/HeJ MGP_C3HHeJ_G0033524
 protein coding gene Chr8:84223421-84253389 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034334
 protein coding gene Chr8:87732064-87762386 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031276
 protein coding gene Chr8:74992012-75022760 (-)
CAST/EiJ MGP_CASTEiJ_G0032854
 protein coding gene Chr8:83622375-83658767 (-)
CBA/J MGP_CBAJ_G0033502
 protein coding gene Chr8:90879896-90921376 (-)
DBA/2J MGP_DBA2J_G0033655
 protein coding gene Chr8:80847480-80878807 (-)
FVB/NJ MGP_FVBNJ_G0033601
 protein coding gene Chr8:79759902-79790065 (-)
LP/J MGP_LPJ_G0033745
 protein coding gene Chr8:84616517-84645929 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033643
 protein coding gene Chr8:93378212-93410778 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034351
 protein coding gene Chr8:83575931-83605259 (-)
PWK/PhJ MGP_PWKPhJ_G0032558
 protein coding gene Chr8:80061124-80091160 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032395
 protein coding gene Chr8:82376922-82406437 (-)
WSB/EiJ MGP_WSBEiJ_G0032967
 protein coding gene Chr8:83980393-84012853 (-)



Homology
more
  • Human Ortholog
    PKN1, protein kinase N1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PKN1, protein kinase N1
  • Synonyms
    DBK, PAK-1, PAK1, PKN, PKN-ALPHA, PRK1, PRKCL1
  • Links
    NCBI Gene ID: 5585
    neXtProt AC: NX_Q16512
    UniProt: Q16512

  • Chr Location
    19p13.12; chr19:14433053-14471867 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    36 phenotypes from 3 alleles in 3 genetic backgrounds
    1 phenotype from multigenic genotypes
    2 images
    52 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a null allele show spontaneous germinal center formation and autoantibody production and develop glomerulonephritis. Homozygotes for a different null allele have mild systolic and diastolic dysfunction, and show increased myocardial infarction size after ischemia-reperfusion injury.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    63
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    764
  • Tissues
    38
  • cDNA Data
    16
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000057672 Ensembl Gene Model | MGI Sequence Detail 32644 C57BL/6J ±  kb
    transcript ENSMUST00000144258 Ensembl | MGI Sequence Detail 2995 Not Applicable  
    polypeptide ENSMUSP00000116235 Ensembl | MGI Sequence Detail 951 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 22
      Genomic 2
      cDNA 20

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-37058, MGI:2444757
    References
    more
    • Summaries
      All 90
      Developmental Gene Expression 5
      Gene Ontology 13
      Phenotypes 52
    • Earliest
      J:13049 Gruneberg H, Genetical studies on the skeleton of the mouse. XVIII. Three genes for syndactylism. J Genet. 1956;54(1):113-145
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory