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Hdac2 Gene Detail
Summary
  • Symbol
    Hdac2
  • Name
    histone deacetylase 2
  • Synonyms
    D10Wsu179e, Yy1bp
  • Feature Type
    protein coding gene
  • IDs
    MGI:1097691
    NCBI Gene: 15182
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:36850540-36877885 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 19.44 cM, cytoband B1
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    771 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1097691
 protein coding gene Chr10:36850293-36877885 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017144
 protein coding gene Chr10:35404599-35438297 (+)
A/J MGP_AJ_G0017121
 protein coding gene Chr10:34476014-34503776 (+)
AKR/J MGP_AKRJ_G0017081
 protein coding gene Chr10:34916578-34943967 (+)
BALB/cJ MGP_BALBcJ_G0017084
 protein coding gene Chr10:34433048-34461074 (+)
C3H/HeJ MGP_C3HHeJ_G0016904
 protein coding gene Chr10:35232683-35268481 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017542
 protein coding gene Chr10:36460965-36490399 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015239
 protein coding gene Chr10:32582731-32610622 (+)
CAST/EiJ MGP_CASTEiJ_G0016483
 protein coding gene Chr10:35414856-35552458 (+)
CBA/J MGP_CBAJ_G0016878
 protein coding gene Chr10:38186927-38217731 (+)
DBA/2J MGP_DBA2J_G0016983
 protein coding gene Chr10:34036478-34064885 (+)
FVB/NJ MGP_FVBNJ_G0016978
 protein coding gene Chr10:33532708-33560125 (+)
LP/J MGP_LPJ_G0017060
 protein coding gene Chr10:35375991-35405826 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017008
 protein coding gene Chr10:38934532-38963179 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017578
 protein coding gene Chr10:34879310-34909784 (+)
PWK/PhJ MGP_PWKPhJ_G0016264
 protein coding gene Chr10:33828730-33896032 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016048
 protein coding gene Chr10:34712226-34740503 (+)
WSB/EiJ MGP_WSBEiJ_G0016546
 protein coding gene Chr10:35172353-35202724 (+)



Homology
more
  • Human Ortholog
    HDAC2, histone deacetylase 2
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HDAC2, histone deacetylase 2
  • Synonyms
    HD2, KDAC2, RPD3, YAF1
  • Links
    NCBI Gene ID: 3066
    neXtProt AC: NX_Q92769
    UniProt: Q92769

  • Chr Location
    6q21; chr6:113933028-114011308 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human HDAC2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    50 phenotypes from 8 alleles in 10 genetic backgrounds
    65 phenotypes from multigenic genotypes
    91 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit embryonic and postnatal lethality accompanied with a transient decrease in body size and increase in heart size and cardiomyocyte proliferation that is overcome by 2 months of age in surviving mice.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    154
  • GO References
    53
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1191
  • Tissues
    227
  • cDNA Data
    65
  • Literature Summary
    60
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000019777 Ensembl Gene Model | MGI Sequence Detail 27346 C57BL/6J ±  kb
    transcript ENSMUST00000019911 Ensembl | MGI Sequence Detail 2005 Not Applicable  
    polypeptide ENSMUSP00000019911 Ensembl | MGI Sequence Detail 488 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 88
      Genomic 4
      cDNA 67
      Primer pair 13
      Other 4

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-36452, MGI:107875
    References
    more
    • Summaries
      All 282
      Developmental Gene Expression 60
      Gene Ontology 53
      Phenotypes 91
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:353625 Zhu Y, et al., HDAC1 and HDAC2 orchestrate Wnt signaling to regulate neural progenitor transition during brain development. iScience. 2024 Sep 20;27(9):110600
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/29/2024
    MGI 6.24     		The Jackson Laboratory