Mpp1 MGI Mouse Gene Detail - MGI:105941 - membrane protein, palmitoylated

Symbol

Mpp1
Name

membrane protein, palmitoylated
Synonyms

55kDa, C130070C03Rik, erythrocyte protein p55, p55

Feature Type

protein coding gene
IDs

MGI:105941
NCBI Gene: 17524
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

ChrX:74153339-74174622 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome X, 38.15 cM
Mapping Data

4 experiments

SNPs within 2kb

359 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_105941	protein coding gene	ChrX:74153339-74174622 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0035854	protein coding gene	ChrX:70940626-70961858 (-)
A/J	MGP_AJ_G0035841	protein coding gene	ChrX:71147317-71168182 (-)
AKR/J	MGP_AKRJ_G0035762	protein coding gene	ChrX:73031372-73055121 (-)
BALB/cJ	MGP_BALBcJ_G0035823	protein coding gene	ChrX:70171108-70192100 (-)
C3H/HeJ	MGP_C3HHeJ_G0035533	protein coding gene	ChrX:71418181-71443188 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0036353	protein coding gene	ChrX:73227692-73248813 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0033192	protein coding gene	ChrX:70613985-70637030 (-)
CAST/EiJ	MGP_CASTEiJ_G0034819	protein coding gene	ChrX:56782886-56803985 (-)
CBA/J	MGP_CBAJ_G0035506	protein coding gene	ChrX:75181682-75203229 (-)
DBA/2J	MGP_DBA2J_G0035664	protein coding gene	ChrX:70627542-70648487 (-)
FVB/NJ	MGP_FVBNJ_G0035605	protein coding gene	ChrX:69936560-69957166 (-)
LP/J	MGP_LPJ_G0035746	protein coding gene	ChrX:71751819-71773032 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0035639	protein coding gene	ChrX:77786848-77809997 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0036379	protein coding gene	ChrX:70795301-70826019 (-)
PWK/PhJ	MGP_PWKPhJ_G0034516	protein coding gene	ChrX:54780562-54802587 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0034352	protein coding gene	ChrX:57607066-57629565 (-)
WSB/EiJ	MGP_WSBEiJ_G0034958	protein coding gene	ChrX:70034631-70057673 (-)

Human Ortholog

MPP1, MAGUK p55 scaffold protein 1

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MPP1, MAGUK p55 scaffold protein 1
Synonyms

AAG12, DXS552E, EMP55, MRG1, PEMP
Links

HGNC:7219

NCBI Gene ID: 4354

neXtProt AC: NX_Q00013

UniProt: Q00013
Chr Location

Xq28; chrX:154778684-154821007 (-) GRCh38

MGI Vertebrate Homology

Mpp1 stringent orthology
1 human;1 mouse;1 zebrafish
HCOP

vertebrate homology predictions: MPP1
Gene Tree

Mpp1

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Phenotype Summary

14 phenotypes from 2 alleles in 2 genetic backgrounds
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Endonuclease-mediated

3
Gene trapped

2
Targeted

3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

11 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele display defects in neutrophil polarity and chemotaxis and produce small litters of pups.

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All GO Annotations

11
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

734
Tissues

22
cDNA Data

106
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase mpp1

ZFIN mpp1

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All Sequences

66
RefSeq

2
UniProt

10
CCDS

CCDS30236.1

Ensembl

ENSMUSG00000031402 (Evidence)
NCBI Gene

17524

			Length	Strain/Species	Flank
genomic	17524	NCBI Gene Model \| MGI Sequence Detail	21284	C57BL/6J	± kb
transcript	NM_008621	RefSeq \| MGI Sequence Detail	2525	ZRU/MplStud
polypeptide	P70290	UniProt \| EBI \| MGI Sequence Detail	466	Not Applicable

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UniProt

10 Sequences
Protein Ontology

PR:000010544 55 kDa erythrocyte membrane protein

(term hierarchy)
InterPro Domains

IPR020590 Guanylate kinase, conserved site

IPR008144 Guanylate kinase-like domain

IPR008145 Guanylate kinase/L-type calcium channel beta subunit

IPR050716 Membrane-associated guanylate kinase

IPR035475 MPP1, SH3 domain

IPR001478 PDZ domain

IPR036034 PDZ superfamily

IPR027417 P-loop containing nucleoside triphosphate hydrolase

IPR001452 SH3 domain

IPR036028 SH3-like domain superfamily
GlyGen

P70290 1 site, 1 O-linked glycan (1 site)

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All nucleic 110

Genomic 2

cDNA 108

Microarray probesets 4

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MGD-MRK-33620, MGI:2444970

Summaries

All 42

Developmental Gene Expression 1

Gene Ontology 7

Phenotypes 10
Earliest

J:31964 Peters LL, et al., Localization of the gene encoding the erythrocyte membrane protein p55 (Mpp1) on the mouse X Chromosome. Mamm Genome. 1996 Mar;7(3):245-6
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Mpp1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr163659	ChrX:74174602-74174615 (-)	13 bp
Tssr163658	ChrX:74174520-74174600 (-)	62 bp
Tssr163657	ChrX:74174498-74174511 (-)	117 bp
Tssr163656	ChrX:74170568-74170577 (-)	4,049 bp
Tssr163655	ChrX:74158271-74158281 (-)	16,346 bp
Tssr163654	ChrX:74157248-74157266 (-)	17,365 bp
Tssr163653	ChrX:74155597-74155617 (-)	19,015 bp
Tssr163652	ChrX:74154207-74154244 (-)	20,396 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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