Rock1 MGI Mouse Gene Detail - MGI:107927 - Rho-associated coiled-coil containing protein kinase 1

Symbol

Rock1
Name

Rho-associated coiled-coil containing protein kinase 1
Synonyms

1110055K06Rik, Rock-I

Feature Type

protein coding gene
IDs

MGI:107927
NCBI Gene: 19877
Alliance

gene page
Transcription Start Sites

18 TSS

Sequence Map

Chr18:10064401-10182045 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 18, 4.91 cM, cytoband A2
Mapping Data

3 experiments

SNPs within 2kb

2145 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_107927	protein coding gene	Chr18:10064401-10182225 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0024146	protein coding gene	Chr18:6999567-7116477 (-)
A/J	MGP_AJ_G0024108	protein coding gene	Chr18:6951559-7072201 (-)
AKR/J	MGP_AKRJ_G0024075	protein coding gene	Chr18:7122330-7252354 (-)
BALB/cJ	MGP_BALBcJ_G0024107	protein coding gene	Chr18:6923527-7056277 (-)
C3H/HeJ	MGP_C3HHeJ_G0023874	protein coding gene	Chr18:7011879-7132088 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0024552	protein coding gene	Chr18:7418899-7533199 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021991	protein coding gene	Chr18:6636535-6757663 (-)
CAST/EiJ	MGP_CASTEiJ_G0023351	protein coding gene	Chr18:6928075-7048875 (-)
CBA/J	MGP_CBAJ_G0023846	protein coding gene	Chr18:7451426-7585248 (-)
DBA/2J	MGP_DBA2J_G0023975	protein coding gene	Chr18:6796028-6914958 (-)
FVB/NJ	MGP_FVBNJ_G0023940	protein coding gene	Chr18:6766037-6883414 (-)
LP/J	MGP_LPJ_G0024058	protein coding gene	Chr18:7106661-7241488 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023969	protein coding gene	Chr18:7636933-7810210 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024598	protein coding gene	Chr18:6947541-7070828 (-)
PWK/PhJ	MGP_PWKPhJ_G0023097	protein coding gene	Chr18:6834098-6961950 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0022907	protein coding gene	Chr18:7259392-7377993 (-)
WSB/EiJ	MGP_WSBEiJ_G0023417	protein coding gene	Chr18:6941195-7061755 (-)

Human Ortholog

ROCK1, Rho associated coiled-coil containing protein kinase 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ROCK1, Rho associated coiled-coil containing protein kinase 1
Synonyms

P160ROCK, ROCK-I
Links

HGNC:10251

NCBI Gene ID: 6093

neXtProt AC: NX_Q13464

UniProt: Q13464
Chr Location

18q11.1; chr18:20944612-21111813 (-) GRCh38

MGI Vertebrate Homology

Rock1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ROCK1
Gene Tree

Rock1

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Phenotype Summary

38 phenotypes from 7 alleles in 7 genetic backgrounds
12 phenotypes from multigenic genotypes
6 images
64 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

24
Endonuclease-mediated

2
Gene trapped

7
Targeted

15
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

60 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice have open eyes at birth, omphalocele and most die soon after birth as a result of cannibalization by the mom. Survivors develop inflammation of the eyelid. Another homozygous mutant shows partial lethality around implantation and reduced cardiac fibrosis after pressure overload.

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All GO Annotations

117
GO References

25

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

778
Tissues

45
cDNA Data

23
Literature Summary

30

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rock1

ZFIN rock1

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All Sequences

63
RefSeq

5
UniProt

5
CCDS

CCDS29053.2

Ensembl

ENSMUSG00000024290 (Evidence)
NCBI Gene

19877

			Length	Strain/Species	Flank
genomic	ENSMUSG00000024290	Ensembl Gene Model \| MGI Sequence Detail	117645	C57BL/6J	± kb
transcript	ENSMUST00000067947	Ensembl \| MGI Sequence Detail	6440	Not Applicable
polypeptide	ENSMUSP00000069549	Ensembl \| MGI Sequence Detail	1354	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000000120 Rho-associated protein kinase 1

(term hierarchy)
EC

2.7.11.1
InterPro Domains

IPR000961 AGC-kinase, C-terminal

IPR046349 C1-like domain superfamily

IPR011072 HR1 rho-binding domain

IPR011993 PH-like domain superfamily

IPR001849 Pleckstrin homology domain

IPR017441 Protein kinase, ATP binding site

IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR020684 Rho-associated protein kinase 1/2

IPR037310 Rho-associated protein kinase 1, HR1

IPR050839 Rho-associated Serine/Threonine Kinase

IPR015008 ROCK, Rho binding domain

IPR008271 Serine/threonine-protein kinase, active site
GlyGen

P70335 3 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (1 site)

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All nucleic 29

cDNA 24

Primer pair 5

Microarray probesets 7

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MGD-MRK-36507, MGI:1916035

Summaries

All 201

Developmental Gene Expression 30

Gene Ontology 25

Phenotypes 64
Earliest

J:35061 Nakagawa O, et al., ROCK-I and ROCK-II, two isoforms of Rho-associated coiled-coil forming protein serine/threonine kinase in mice. FEBS Lett. 1996 Aug 26;392(2):189-93
Latest

J:350506 Akamine T, et al., Conditional deficiency of Rho-associated kinases disrupts endothelial cell junctions and impairs respiratory function in adult mice. FEBS Open Bio. 2024 Jun;14(6):906-921

TSS for Rock1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr152426	Chr18:10182183-10182223 (-)	-158 bp
Tssr152425	Chr18:10182162-10182179 (-)	-126 bp
Tssr152424	Chr18:10182128-10182151 (-)	-95 bp
Tssr152423	Chr18:10182095-10182107 (-)	-56 bp
Tssr152422	Chr18:10182068-10182092 (-)	-35 bp
Tssr152421	Chr18:10182034-10182053 (-)	1 bp
Tssr152420	Chr18:10182010-10182032 (-)	24 bp
Tssr152419	Chr18:10181326-10181356 (-)	704 bp
Tssr152418	Chr18:10172446-10172451 (-)	9,596 bp
Tssr152416	Chr18:10125602-10125606 (-)	56,441 bp
Tssr152415	Chr18:10116841-10116871 (-)	65,189 bp
Tssr152414	Chr18:10106443-10106462 (-)	75,592 bp
Tssr152413	Chr18:10104455-10104478 (-)	77,578 bp
Tssr152412	Chr18:10100946-10100955 (-)	81,094 bp
Tssr152411	Chr18:10093943-10093967 (-)	88,090 bp
Tssr152410	Chr18:10090881-10090923 (-)	91,143 bp
Tssr152409	Chr18:10083179-10083197 (-)	98,857 bp
Tssr152408	Chr18:10065838-10065840 (-)	116,206 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 10/22/2024 MGI 6.24