Casp4 MGI Mouse Gene Detail - MGI:107700 - caspase 4, apoptosis-related cysteine peptidase

Symbol

Casp4
Name

caspase 4, apoptosis-related cysteine peptidase
Synonyms

Casp11, Caspase-11, ich-3

Feature Type

protein coding gene
IDs

MGI:107700
NCBI Gene: 12363
Alliance

gene page
Transcription Start Sites

16 TSS

Sequence Map

Chr9:5308828-5336783 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 2.46 cM, cytoband A1
Mapping Data

3 experiments

SNPs within 2kb

895 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_107700	protein coding gene	Chr9:5308816-5336791 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0034313	protein coding gene	Chr9:2070461-2106187 (+)
A/J	MGP_AJ_G0034290	protein coding gene	Chr9:2178098-2205460 (+)
AKR/J	MGP_AKRJ_G0034220	protein coding gene	Chr9:2038437-2066492 (+)
BALB/cJ	MGP_BALBcJ_G0034284	protein coding gene	Chr9:1972436-2000737 (+)
C3H/HeJ	MGP_C3HHeJ_G0033996	protein coding gene	Chr9:2237841-2266236 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0034806	protein coding gene	Chr9:2216125-2249033 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031744	protein coding gene	Chr9:1718573-1745166 (+)
CAST/EiJ	MGP_CASTEiJ_G0033323	protein coding gene	Chr9:2273404-2302145 (+)
CBA/J	MGP_CBAJ_G0033968	protein coding gene	Chr9:2189595-2223584 (+)
DBA/2J	MGP_DBA2J_G0034125	protein coding gene	Chr9:2157194-2185446 (+)
FVB/NJ	MGP_FVBNJ_G0034070	protein coding gene	Chr9:1967898-1995513 (+)
LP/J	MGP_LPJ_G0034212	protein coding gene	Chr9:2089545-2120742 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0034114	protein coding gene	Chr9:2689422-2731361 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0034825	protein coding gene	Chr9:2041173-2074550 (+)
PWK/PhJ	MGP_PWKPhJ_G0033027	protein coding gene	Chr9:2272632-2307501 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0032864	protein coding gene	Chr9:2334133-2363637 (+)
WSB/EiJ	MGP_WSBEiJ_G0033439	protein coding gene	Chr9:2072211-2100688 (+)

Human Ortholog

CASP4, caspase 4

Vertebrate Orthologs

7

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CASP4, caspase 4
Synonyms

ICE(rel)II, ICEREL-II, ICH-2, Mih1, Mih1/TX, TX
Links

HGNC:1505

NCBI Gene ID: 837

neXtProt AC: NX_P49662

UniProt: P49662
Chr Location

11q22.3; chr11:104942866-104969366 (-) GRCh38

Human Ortholog

CASP5, caspase 5
Synonyms

ICE(rel)III, ICEREL-III, ICH-3
Links

HGNC:1506

NCBI Gene ID: 838

neXtProt AC: NX_P51878

UniProt: P51878
Chr Location

11q22.3; chr11:104994235-105023168 (-) GRCh38

MGI Vertebrate Homology

Casp4 stringent orthology
2 human;1 mouse;1 rat;4 zebrafish
HCOP

vertebrate homology predictions: CASP4, CASP5
Protein SuperFamily

Caspase_ICE
Gene Tree

Casp4

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Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

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Phenotype Summary

14 phenotypes from 3 alleles in 5 genetic backgrounds
53 phenotypes from multigenic genotypes
180 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

16
Endonuclease-mediated

6
Spontaneous

1
Targeted

8
Transgenic

1
Genomic Mutations

1 involving Casp4
Incidental Mutations

CvDC
Find Mice (IMSR)

33 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mutation of this gene results in decreased levels of serum IL-1alpha and IL-1beta. Mutant animals are resistant to septic shock after injection with LPS.

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All GO Annotations

71
GO References

27

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

849
Tissues

94
cDNA Data

29
Literature Summary

13

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

63
RefSeq

18
UniProt

3
CCDS

CCDS22799.1

Ensembl

ENSMUSG00000033538 (Evidence)
NCBI Gene

12363

			Length	Strain/Species	Flank
genomic	ENSMUSG00000033538	Ensembl Gene Model \| MGI Sequence Detail	27956	C57BL/6J	± kb
transcript	ENSMUST00000027012	Ensembl \| MGI Sequence Detail	1435	Not Applicable
polypeptide	ENSMUSP00000027012	Ensembl \| MGI Sequence Detail	373	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000002313 caspase-4

(term hierarchy)
PDB

6KMT, 6KMU, 6KMV, 6KN1, 6NS7
EC

3.4.22.64
InterPro Domains

IPR001315 CARD domain

IPR029030 Caspase-like domain superfamily

IPR011029 Death-like domain superfamily

IPR015917 Peptidase C14A, caspase catalytic domain

IPR011600 Peptidase C14, caspase domain

IPR002138 Peptidase C14, caspase non-catalytic subunit p10

IPR001309 Peptidase C14, p20 domain

IPR033139 Peptidase family C14A, cysteine active site

IPR016129 Peptidase family C14A, His active site

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All nucleic 38

Genomic 1

cDNA 30

Primer pair 6

Other 1

Microarray probesets 3

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MGD-MRK-36276

Summaries

All 284

Developmental Gene Expression 13

Diseases 1

Gene Ontology 27

Phenotypes 180
Earliest

J:34885 Wang S, et al., Identification and characterization of Ich-3, a member of the interleukin-1beta converting enzyme (ICE)/Ced-3 family and an upstream regulator of ICE. J Biol Chem. 1996 Aug 23;271(34):20580-7
Latest

J:358149 Pizzuto M, et al., Ornithine lipid is a partial TLR4 agonist and NLRP3 activator. Cell Rep. 2024 Oct 22;43(10):114788

TSS for Casp4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr83646	Chr9:5308842-5308873 (+)	30 bp
Tssr83647	Chr9:5309658-5309679 (+)	841 bp
Tssr83648	Chr9:5310306-5310313 (+)	1,482 bp
Tssr83649	Chr9:5311985-5311998 (+)	3,164 bp
Tssr83650	Chr9:5312159-5312172 (+)	3,338 bp
Tssr83651	Chr9:5312856-5312867 (+)	4,034 bp
Tssr83652	Chr9:5312869-5312880 (+)	4,047 bp
Tssr83653	Chr9:5312883-5312898 (+)	4,063 bp
Tssr83654	Chr9:5312912-5312924 (+)	4,090 bp
Tssr83655	Chr9:5321297-5321311 (+)	12,476 bp
Tssr83656	Chr9:5323709-5323723 (+)	14,888 bp
Tssr83657	Chr9:5323793-5323806 (+)	14,972 bp
Tssr83658	Chr9:5327222-5327238 (+)	18,402 bp
Tssr83659	Chr9:5327278-5327295 (+)	18,459 bp
Tssr83660	Chr9:5332819-5332833 (+)	23,998 bp
Tssr83661	Chr9:5335408-5335424 (+)	26,588 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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