Irf7 MGI Mouse Gene Detail - MGI:1859212 - interferon regulatory factor 7

Symbol

Irf7
Name

interferon regulatory factor 7

Feature Type

protein coding gene
IDs

MGI:1859212
NCBI Gene: 54123
Alliance

gene page
Transcription Start Sites

17 TSS

Sequence Map

Chr7:140843096-140846412 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 86.57 cM, cytoband F5
Mapping Data

2 experiments

SNPs within 2kb

163 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1859212	protein coding gene	Chr7:140842619-140846412 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0033219	protein coding gene	Chr7:146442872-146446647 (-)
A/J	MGP_AJ_G0033201	protein coding gene	Chr7:142254328-142258103 (-)
AKR/J	MGP_AKRJ_G0033133	protein coding gene	Chr7:146183052-146186827 (-)
BALB/cJ	MGP_BALBcJ_G0033202	protein coding gene	Chr7:141998290-142002065 (-)
C3H/HeJ	MGP_C3HHeJ_G0032916	protein coding gene	Chr7:145941694-145945469 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0033713	protein coding gene	Chr7:151794393-151798168 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030686	protein coding gene	Chr7:143463909-143467695 (-)
CAST/EiJ	MGP_CASTEiJ_G0032246	protein coding gene	Chr7:138241020-138244776 (-)
CBA/J	MGP_CBAJ_G0032888	protein coding gene	Chr7:156925228-156929003 (-)
DBA/2J	MGP_DBA2J_G0033040	protein coding gene	Chr7:140203069-140206844 (-)
FVB/NJ	MGP_FVBNJ_G0032993	protein coding gene	Chr7:140115324-140119099 (-)
LP/J	MGP_LPJ_G0033135	protein coding gene	Chr7:147940990-147944765 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033026	protein coding gene	Chr7:157587350-157591125 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0033733	protein coding gene	Chr7:145157121-145160896 (-)
PWK/PhJ	MGP_PWKPhJ_G0031950	protein coding gene	Chr7:133481172-133484963 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0031797	protein coding gene	Chr7:131980014-131983809 (-)
WSB/EiJ	MGP_WSBEiJ_G0032357	protein coding gene	Chr7:146101663-146105438 (-)

Human Ortholog

IRF7, interferon regulatory factor 7

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

IRF7, interferon regulatory factor 7
Synonyms

IMD39, IRF-7, IRF7A, IRF7B, IRF7C, IRF-7H, IRF7H
Links

HGNC:6122

NCBI Gene ID: 3665

neXtProt AC: NX_Q92985

UniProt: Q92985
Chr Location

11p15.5; chr11:612553-615983 (-) GRCh38

MGI Vertebrate Homology

Irf7 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: IRF7
Gene Tree

Irf7

Diseases

1 with human IRF7 associations

				Human Disease	Mouse Models
				immunodeficiency 39 IDs immunodeficiency 39 DOID:0111969 OMIM:616345

Click on a disease name to see all genes associated with that disease.

less

Phenotype Summary

10 phenotypes from 4 alleles in 5 genetic backgrounds
5 phenotypes from multigenic genotypes
185 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Chemically induced (ENU)

2
Endonuclease-mediated

2
Gene trapped

1
Radiation induced

1
Targeted

3
Genomic Mutations

1 involving Irf7
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

23 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice are more vulnerable to viral infection and exhibit decreased serum interferon levels in response to viral infection.

less

All GO Annotations

56
GO References

15

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

851
Tissues

128
cDNA Data

92
Literature Summary

17

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA IRF7

Xenbase irf7

ZFIN irf7

less

All Sequences

72
RefSeq

8
UniProt

6
CCDS

CCDS22005.1, CCDS57594.1, CCDS57595.1

Ensembl

ENSMUSG00000025498 (Evidence)
NCBI Gene

54123

			Length	Strain/Species	Flank
genomic	54123	NCBI Gene Model \| MGI Sequence Detail	3317	C57BL/6J	± kb
transcript	NM_016850	RefSeq \| MGI Sequence Detail	1876	C57BL/6
polypeptide	P70434	UniProt \| EBI \| MGI Sequence Detail	457	Not Applicable

less

UniProt

6 Sequences
Protein Ontology

PR:000002049 interferon regulatory factor 7

(term hierarchy)
PDB

3QU3
InterPro Domains

IPR019471 Interferon regulatory factor-3

IPR019817 Interferon regulatory factor, conserved site

IPR001346 Interferon regulatory factor, DNA-binding domain

IPR008984 SMAD/FHA domain superfamily

IPR017855 SMAD-like domain superfamily

IPR036390 Winged helix DNA-binding domain superfamily

IPR036388 Winged helix-like DNA-binding domain superfamily

less

All nucleic 101

Genomic 2

cDNA 94

Primer pair 4

Other 1

Microarray probesets 4

Summaries

All 272

Developmental Gene Expression 17

Gene Ontology 15

Phenotypes 185
Earliest

J:65007 Cattanach BM, et al., Two imprinted gene mutations: three phenotypes. Hum Mol Genet. 2000 Sep 22;9(15):2263-73
Latest

J:354283 Wang C, et al., Deficiency of Tlr7 and Irf7 in mice increases the severity of COVID-19 through the reduced interferon production. Commun Biol. 2024 Sep 17;7(1):1162

TSS for Irf7:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr75620	Chr7:140846328-140846343 (-)	76 bp
Tssr75619	Chr7:140845931-140845943 (-)	475 bp
Tssr75618	Chr7:140845873-140845906 (-)	522 bp
Tssr75617	Chr7:140845841-140845854 (-)	564 bp
Tssr75616	Chr7:140845770-140845794 (-)	630 bp
Tssr75615	Chr7:140845632-140845652 (-)	770 bp
Tssr75614	Chr7:140845366-140845392 (-)	1,033 bp
Tssr75613	Chr7:140845156-140845171 (-)	1,248 bp
Tssr75612	Chr7:140844428-140844439 (-)	1,978 bp
Tssr75611	Chr7:140844166-140844187 (-)	2,235 bp
Tssr75610	Chr7:140843910-140843923 (-)	2,495 bp
Tssr75609	Chr7:140843885-140843902 (-)	2,518 bp
Tssr75608	Chr7:140843867-140843884 (-)	2,536 bp
Tssr75607	Chr7:140843810-140843830 (-)	2,592 bp
Tssr75606	Chr7:140843734-140843755 (-)	2,667 bp
Tssr75605	Chr7:140843596-140843677 (-)	2,775 bp
Tssr75604	Chr7:140843438-140843483 (-)	2,951 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 10/29/2024 MGI 6.24