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Eif4ebp2 Gene Detail
Summary
  • Symbol
    Eif4ebp2
  • Name
    eukaryotic translation initiation factor 4E binding protein 2
  • Synonyms
    2810011I19Rik, 4E-BP2, PHAS-II
  • Feature Type
    protein coding gene
  • IDs
    MGI:109198
    NCBI Gene: 13688
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:61268276-61288448 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 32.21 cM, cytoband B4-B5
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    441 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109198
 protein coding gene Chr10:61264270-61288448 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017280
 protein coding gene Chr10:60776907-60797249 (-)
A/J MGP_AJ_G0017258
 protein coding gene Chr10:58950529-58973605 (-)
AKR/J MGP_AKRJ_G0017218
 protein coding gene Chr10:60493848-60513505 (-)
BALB/cJ MGP_BALBcJ_G0017218
 protein coding gene Chr10:59036048-59057252 (-)
C3H/HeJ MGP_C3HHeJ_G0017041
 protein coding gene Chr10:60398180-60417674 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017676
 protein coding gene Chr10:62937196-62959825 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015367
 protein coding gene Chr10:55932905-55952041 (-)
CAST/EiJ MGP_CASTEiJ_G0016612
 protein coding gene Chr10:60393759-60412324 (-)
CBA/J MGP_CBAJ_G0017013
 protein coding gene Chr10:65295244-65323536 (-)
DBA/2J MGP_DBA2J_G0017118
 protein coding gene Chr10:58226639-58249387 (-)
FVB/NJ MGP_FVBNJ_G0017112
 protein coding gene Chr10:57482302-57503295 (-)
LP/J MGP_LPJ_G0017193
 protein coding gene Chr10:61164789-61195313 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017140
 protein coding gene Chr10:67611268-67630754 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017714
 protein coding gene Chr10:60314746-60335956 (-)
PWK/PhJ MGP_PWKPhJ_G0016395
 protein coding gene Chr10:58066861-58086394 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016178
 protein coding gene Chr10:59663461-59685642 (-)
WSB/EiJ MGP_WSBEiJ_G0016676
 protein coding gene Chr10:60233251-60252743 (-)



Homology
more
  • Human Ortholog
    EIF4EBP2, eukaryotic translation initiation factor 4E binding protein 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EIF4EBP2, eukaryotic translation initiation factor 4E binding protein 2
  • Synonyms
    4EBP2, PHASII
  • Links
    NCBI Gene ID: 1979
    neXtProt AC: NX_Q13542
    UniProt: Q13542

  • Chr Location
    10q22.1; chr10:70404145-70428618 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Eif4ebp2 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 1 allele in 1 genetic background
    60 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele display altered synaptic transmission, impaired spatial learning, and long-term memory deficits, and autism-like behaviors including abnormal social investigation, repetitive behaviors and abnormal vocalization.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    718
  • Tissues
    3
  • cDNA Data
    13
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 13688 NCBI Gene Model | MGI Sequence Detail 20173 C57BL/6J ±  kb
    transcript NM_010124 RefSeq | MGI Sequence Detail 1786 ZRU/MplStud  
    polypeptide P70445 UniProt | EBI | MGI Sequence Detail 120 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000006995 eukaryotic translation initiation factor 4E-binding protein 2
      (term hierarchy)
    • InterPro Domains
      IPR008606 Eukaryotic translation initiation factor 4E binding
    • GlyGen
      P70445 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 14
      Genomic 1
      cDNA 13

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-38242, MGI:1916479, MGI:2143510, MGI:2652850
    References
    more
    • Summaries
      All 102
      Developmental Gene Expression 5
      Diseases 1
      Gene Ontology 11
      Phenotypes 60
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:332823 Miller WP, et al., Activation of Disulfide Redox Switch in REDD1 Promotes Oxidative Stress Under Hyperglycemic Conditions. Diabetes. 2022 Dec 1;71(12):2764-2776
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory