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Irx3 Gene Detail
Summary
  • Symbol
    Irx3
  • Name
    Iroquois related homeobox 3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1197522
    NCBI Gene: 16373
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:92525139-92528282 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 44.55 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    96 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1197522
 protein coding gene Chr8:92525139-92528695 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033933
 protein coding gene Chr8:93056618-93060001 (-)
A/J MGP_AJ_G0033916
 protein coding gene Chr8:89392874-89396265 (-)
AKR/J MGP_AKRJ_G0033842
 protein coding gene Chr8:91920919-91924302 (-)
BALB/cJ MGP_BALBcJ_G0033908
 protein coding gene Chr8:89560332-89563715 (-)
C3H/HeJ MGP_C3HHeJ_G0033618
 protein coding gene Chr8:92614457-92617896 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034429
 protein coding gene Chr8:96488743-96492135 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031370
 protein coding gene Chr8:83341150-83344526 (-)
CAST/EiJ MGP_CASTEiJ_G0032950
 protein coding gene Chr8:92142698-92146082 (-)
CBA/J MGP_CBAJ_G0033594
 protein coding gene Chr8:99716348-99719731 (-)
DBA/2J MGP_DBA2J_G0033748
 protein coding gene Chr8:88946429-88949812 (-)
FVB/NJ MGP_FVBNJ_G0033695
 protein coding gene Chr8:87877573-87880956 (-)
LP/J MGP_LPJ_G0033840
 protein coding gene Chr8:93179295-93182678 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033737
 protein coding gene Chr8:102135183-102138568 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034447
 protein coding gene Chr8:92019937-92023320 (-)
PWK/PhJ MGP_PWKPhJ_G0032652
 protein coding gene Chr8:88260683-88282141 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032489
 protein coding gene Chr8:90886735-90890116 (-)
WSB/EiJ MGP_WSBEiJ_G0033062
 protein coding gene Chr8:92474656-92478039 (-)



Homology
more
  • Human Ortholog
    IRX3, iroquois homeobox 3
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IRX3, iroquois homeobox 3
  • Synonyms
    IRX-1, IRXB1
  • Links
    NCBI Gene ID: 79191
    neXtProt AC: NX_P78415
    UniProt: P78415

  • Chr Location
    16q12.2; chr16:54283304-54286787 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 2 alleles in 3 genetic backgrounds
    13 phenotypes from multigenic genotypes
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele display right bundle branch block, decreased body weight, increased energy expenditure, reduced adiposity and decreased susceptibility to diet induced obesity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1563
  • Tissues
    534
  • cDNA Data
    66
  • Literature Summary
    151
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16373 NCBI Gene Model | MGI Sequence Detail 3144 C57BL/6J ±  kb
    transcript NM_001253822 RefSeq | MGI Sequence Detail 2363 ZRU/MplStud  
    polypeptide P81067 UniProt | EBI | MGI Sequence Detail 507 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 89
      cDNA 69
      Primer pair 10
      Other 10

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2142650
    References
    more
    • Summaries
      All 188
      Developmental Gene Expression 151
      Gene Ontology 11
      Phenotypes 20
    • Earliest
      J:45683 Bosse A, et al., Identification of the vertebrate Iroquois homeobox gene family with overlapping expression during early development of the nervous system. Mech Dev. 1997 Dec;69(1-2):169-81
    • Latest
      J:355142 Gomez-Del Arco P, et al., The G4 resolvase Dhx36 modulates cardiomyocyte differentiation and ventricular conduction system development. Nat Commun. 2024 Oct 4;15(1):8602
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory