Gabpb2 MGI Mouse Gene Detail - MGI:95612 - GA repeat binding protein, beta 2

Symbol

Gabpb2
Name

GA repeat binding protein, beta 2
Synonyms

1810015F01Rik, 9430006E19Rik, A430024B14Rik, Gabpb2-1

Feature Type

protein coding gene
IDs

MGI:95612
NCBI Gene: 213054
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr3:95089077-95125227 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 40.74 cM, cytoband F2
Mapping Data

7 experiments

SNPs within 2kb

722 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_95612	protein coding gene	Chr3:95089077-95125291 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0027574	protein coding gene	Chr3:95882264-95924263 (-)
A/J	MGP_AJ_G0027533	protein coding gene	Chr3:92929044-92960027 (-)
AKR/J	MGP_AKRJ_G0027500	protein coding gene	Chr3:95071168-95105456 (-)
BALB/cJ	MGP_BALBcJ_G0027545	protein coding gene	Chr3:92699046-92736087 (-)
C3H/HeJ	MGP_C3HHeJ_G0027278	protein coding gene	Chr3:95352238-95392009 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0027993	protein coding gene	Chr3:99449789-99491780 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025333	protein coding gene	Chr3:89288843-89322516 (-)
CAST/EiJ	MGP_CASTEiJ_G0026728	protein coding gene	Chr3:94632761-94670610 (-)
CBA/J	MGP_CBAJ_G0027255	protein coding gene	Chr3:103056158-103097728 (-)
DBA/2J	MGP_DBA2J_G0027394	protein coding gene	Chr3:92217520-92251514 (-)
FVB/NJ	MGP_FVBNJ_G0027365	protein coding gene	Chr3:90283631-90324218 (-)
LP/J	MGP_LPJ_G0027503	protein coding gene	Chr3:97191304-97229163 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027392	protein coding gene	Chr3:109182347-109214975 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028047	protein coding gene	Chr3:94725342-94762248 (-)
PWK/PhJ	MGP_PWKPhJ_G0026456	protein coding gene	Chr3:92099127-92129547 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0026277	protein coding gene	Chr3:93016552-93056790 (-)
WSB/EiJ	MGP_WSBEiJ_G0026810	protein coding gene	Chr3:95109281-95146178 (-)

Human Ortholog

GABPB2, GA binding protein transcription factor subunit beta 2

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GABPB2, GA binding protein transcription factor subunit beta 2
Synonyms

GABPB-2
Links

HGNC:28441

NCBI Gene ID: 126626

neXtProt AC: NX_Q8TAK5

UniProt: Q8TAK5
Chr Location

1q21.3; chr1:151070578-151125542 (+) GRCh38

MGI Vertebrate Homology

Gabpb2 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: GABPB2
Gene Tree

Gabpb2

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References

1 with disease annotations

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

32
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

26
Radiation induced

1
Targeted

1
Genomic Mutations

2 involving Gabpb2
Incidental Mutations

APF
Find Mice (IMSR)

32 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a gene trapped allele are viable with normal T and B cell development but show increased B cell proliferation in response to B cell receptor stimulation, and moderately increased antibody production and germinal center responses when challenged with T-dependent antigens.

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All GO Annotations

7
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

800
Tissues

94
cDNA Data

98
Literature Summary

3

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase gabpb2

ZFIN gabpb2a

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All Sequences

86
RefSeq

24
UniProt

4
CCDS

CCDS17605.1

Ensembl

ENSMUSG00000038766 (Evidence)
NCBI Gene

213054

			Length	Strain/Species	Flank
genomic	ENSMUSG00000038766	Ensembl Gene Model \| MGI Sequence Detail	36151	C57BL/6J	± kb
transcript	ENSMUST00000107209	Ensembl \| MGI Sequence Detail	8357	Not Applicable
polypeptide	ENSMUSP00000102827	Ensembl \| MGI Sequence Detail	414	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000007765 GA-binding protein subunit beta-2

(term hierarchy)
InterPro Domains

IPR002110 Ankyrin repeat

IPR050663 Ankyrin Repeat and SOCS Box

IPR036770 Ankyrin repeat-containing domain superfamily

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All nucleic 100

Genomic 1

cDNA 99

Microarray probesets 6

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MGD-MRK-9921, MGI:1916324, MGI:1924499, MGI:2139930, MGI:2443474

Summaries

All 43

Developmental Gene Expression 3

Diseases 1

Gene Ontology 3

Phenotypes 13
Earliest

J:19614 de la Brousse FC, et al., Molecular and genetic characterization of GABP beta. Genes Dev. 1994 Aug 1;8(15):1853-65
Latest

J:302829 Lu J, et al., Mouse models for human hyperuricaemia: a critical review. Nat Rev Rheumatol. 2019 Jul;15(7):413-426

TSS for Gabpb2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr34434	Chr3:95127212-95127228 (-)	-1,993 bp
Tssr34433	Chr3:95127041-95127052 (-)	-1,820 bp
Tssr34432	Chr3:95126867-95126879 (-)	-1,646 bp
Tssr34431	Chr3:95125242-95125300 (-)	-44 bp
Tssr34430	Chr3:95125188-95125229 (-)	18 bp
Tssr34429	Chr3:95125052-95125076 (-)	163 bp
Tssr34428	Chr3:95125001-95125039 (-)	207 bp
Tssr34427	Chr3:95101047-95101049 (-)	24,179 bp
Tssr34426	Chr3:95098073-95098078 (-)	27,151 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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