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Adm Gene Detail
Summary
  • Symbol
    Adm
  • Name
    adrenomedullin
  • Synonyms
    AM
  • Feature Type
    protein coding gene
  • IDs
    MGI:108058
    NCBI Gene: 11535
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:110226868-110229027 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 57.70 cM
  • Mapping Data
    11 experiments
Strain
Comparison
more
  • SNPs within 2kb
    116 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_108058
 protein coding gene Chr7:110226864-110229027 (+)
129S1/SvImJ MGP_129S1SvImJ_G0032858
 protein coding gene Chr7:114134248-114136407 (+)
A/J MGP_AJ_G0032842
 protein coding gene Chr7:111305840-111307991 (+)
AKR/J MGP_AKRJ_G0032773
 protein coding gene Chr7:114085816-114087967 (+)
BALB/cJ MGP_BALBcJ_G0032846
 protein coding gene Chr7:110985576-110987735 (+)
C3H/HeJ MGP_C3HHeJ_G0032556
 protein coding gene Chr7:114100450-114102609 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033352
 protein coding gene Chr7:118849571-118851730 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030324
 protein coding gene Chr7:112907437-112909591 (+)
CAST/EiJ MGP_CASTEiJ_G0031884
 protein coding gene Chr7:105681789-105683948 (+)
CBA/J MGP_CBAJ_G0032529
 protein coding gene Chr7:122731760-122733921 (+)
DBA/2J MGP_DBA2J_G0032681
 protein coding gene Chr7:109388172-109390331 (+)
FVB/NJ MGP_FVBNJ_G0032634
 protein coding gene Chr7:109242829-109244988 (+)
LP/J MGP_LPJ_G0032775
 protein coding gene Chr7:115654684-115656843 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032666
 protein coding gene Chr7:124388619-124390779 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033373
 protein coding gene Chr7:113104638-113106783 (+)
PWK/PhJ MGP_PWKPhJ_G0031591
 protein coding gene Chr7:102226181-102228412 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031439
 protein coding gene Chr7:99842857-99845024 (+)
WSB/EiJ MGP_WSBEiJ_G0031997
 protein coding gene Chr7:113960739-113962903 (+)



Homology
more
  • Human Ortholog
    ADM, adrenomedullin
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ADM, adrenomedullin
  • Synonyms
    AM, PAMP
  • Links
    NCBI Gene ID: 133
    neXtProt AC: NX_P35318
    UniProt: P35318

  • Chr Location
    11p15.4; chr11:10305073-10307397 (+)  GRCh38
Human Diseases
more
  • Diseases
    4 with human ADM associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    54 phenotypes from 7 alleles in 8 genetic backgrounds
    6 phenotypes from multigenic genotypes
    5 images
    52 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit cardiovascular defects, hyrdops fetalis, and lethality at midgestation with defects in placental defects, impaired fetal blood vessel and materal spiral artery remodeling, and decreased uterine NK cell numbers.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    75
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    996
  • Tissues
    190
  • cDNA Data
    137
  • Literature Summary
    36
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000030790 Ensembl Gene Model | MGI Sequence Detail 2160 C57BL/6J ±  kb
    transcript ENSMUST00000033054 Ensembl | MGI Sequence Detail 1390 Not Applicable  
    polypeptide ENSMUSP00000033054 Ensembl | MGI Sequence Detail 184 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 149
      Genomic 1
      cDNA 138
      Primer pair 9
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-37094
    References
    more
    • Summaries
      All 133
      Developmental Gene Expression 36
      Gene Ontology 8
      Phenotypes 52
    • Earliest
      J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
    • Latest
      J:342367 Zhang Q, et al., Adrenomedullin has a pivotal role in trophoblast differentiation: A promising nanotechnology-based therapeutic target for early-onset preeclampsia. Sci Adv. 2023 Nov 3;9(44):eadi4777
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Send questions and comments to User Support.     		last database update
    10/29/2024
    MGI 6.24     		The Jackson Laboratory