Taf1b MGI Mouse Gene Detail - MGI:109577 - TATA-box binding protein associated factor, RNA polymerase I, B

Symbol

Taf1b
Name

TATA-box binding protein associated factor, RNA polymerase I, B
Synonyms

4930408G01Rik, A230108M10Rik, mTAFI68, p63

Feature Type

protein coding gene
IDs

MGI:109577
NCBI Gene: 21340
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr12:24548580-24608570 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 8.49 cM, cytoband A3
Mapping Data

4 experiments

SNPs within 2kb

1245 from dbSNP Build 142
Strain Annotations

17

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_109577	protein coding gene	Chr12:24548358-24608570 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019628	protein coding gene	Chr12:22160027-22236992 (+)
A/J	MGP_AJ_G0019595	protein coding gene	Chr12:21549670-21630865 (+)
AKR/J	MGP_AKRJ_G0019566	protein coding gene	Chr12:22285891-22358128 (+)
BALB/cJ	MGP_BALBcJ_G0019572	protein coding gene	Chr12:21839804-21901259 (+)
C3H/HeJ	MGP_C3HHeJ_G0019376	protein coding gene	Chr12:22156695-22241422 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020020	protein coding gene	Chr12:22857479-22919986 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017644	protein coding gene	Chr12:21036889-21114668 (+)
CAST/EiJ	MGP_CASTEiJ_G0018931	protein coding gene	Chr12:17118687-17187233 (+)
CBA/J	no annotation
DBA/2J	MGP_DBA2J_G0019461	protein coding gene	Chr12:21421574-21484174 (+)
FVB/NJ	MGP_FVBNJ_G0019452	protein coding gene	Chr12:21309481-21372598 (+)
LP/J	MGP_LPJ_G0019531	protein coding gene	Chr12:22222847-22304514 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019487	protein coding gene	Chr12:23427918-23519776 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020059	protein coding gene	Chr12:21837088-21918822 (+)
PWK/PhJ	MGP_PWKPhJ_G0018698	protein coding gene	Chr12:16145198-16211404 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018485	protein coding gene	Chr12:16339600-16422622 (+)
WSB/EiJ	MGP_WSBEiJ_G0018982	protein coding gene	Chr12:21992561-22073255 (+)

Human Ortholog

TAF1B, TATA-box binding protein associated factor, RNA polymerase I subunit B

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TAF1B, TATA-box binding protein associated factor, RNA polymerase I subunit B
Synonyms

MGC:9349, RAF1B, RAFI63, SL1, TAFI63
Links

HGNC:11533

NCBI Gene ID: 9014

neXtProt AC: NX_Q53T94

UniProt: Q53T94
Chr Location

2p25.1; chr2:9843442-9934416 (+) GRCh38

MGI Vertebrate Homology

Taf1b stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TAF1B
Gene Tree

Taf1b

Diseases

2 with human TAF1B associations

				Human Disease	Mouse Models
				Lynch syndrome IDs Lynch syndrome DOID:3883 DOID:0050586 DOID:3040 MESH:D003123 NCI:C8494 OMIM:PS120435 ORDO:144 UMLS_CUI:C0009405 UMLS_CUI:C4552100
				mismatch repair cancer syndrome IDs mismatch repair cancer syndrome DOID:0112182 OMIM:276300 ORDO:252202

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

2 phenotypes from 2 alleles in 2 genetic backgrounds
1 phenotype from multigenic genotypes
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

13
Endonuclease-mediated

1
Gene trapped

8
Targeted

4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

36 strains or lines available

Homozygous null mice die prior to E6.5.

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All GO Annotations

21
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

708
Tissues

2
cDNA Data

16
Literature Summary

2

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase taf1b

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All Sequences

51
RefSeq

5
UniProt

2
CCDS

CCDS36419.1

Ensembl

ENSMUSG00000059669 (Evidence)
NCBI Gene

21340

			Length	Strain/Species	Flank
genomic	21340	NCBI Gene Model \| MGI Sequence Detail	59991	C57BL/6J	± kb
transcript	NM_020614	RefSeq \| MGI Sequence Detail	2019	C57BL/6
polypeptide	P97358	UniProt \| EBI \| MGI Sequence Detail	586	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000016021 TATA box-binding protein-associated factor RNA polymerase I subunit B

(term hierarchy)
InterPro Domains

IPR033599 RNA polymerase I transcription initiation factor TAF1B/Rrn7

IPR048538 Rrn7/TAF1B, C-terminal cyclin domain

IPR048540 Rrn7/TAF1B, N-terminal cyclin domain

IPR021752 Transcription initiation factor Rrn7, Zinc-finger

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All nucleic 17

cDNA 17

Microarray probesets 3

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MGD-MRK-39576, MGI:1922100, MGI:1925679

Summaries

All 40

Developmental Gene Expression 2

Gene Ontology 7

Phenotypes 6
Earliest

J:35896 Almendral JM, et al., Expression, cloning and cDNA sequence of a fibroblast serum-regulated gene encoding a putative actin-associated protein (p27). Exp Cell Res. 1989 Apr;181(2):518-30
Latest

J:321558 Tremblay MG, et al., Ribosomal DNA promoter recognition is determined in vivo by cooperation between UBTF1 and SL1 and is compromised in the UBTF-E210K neuroregression syndrome. PLoS Genet. 2022 Feb;18(2):e1009644

TSS for Taf1b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr112945	Chr12:24548569-24548586 (+)	-2 bp
Tssr112946	Chr12:24548590-24548616 (+)	23 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24