Kcnab3 MGI Mouse Gene Detail - MGI:1336208 - potassium voltage-gated channel, shaker-related subfamily, beta member 3

Symbol

Kcnab3
Name

potassium voltage-gated channel, shaker-related subfamily, beta member 3
Synonyms

C330022D06Rik, Kcnab4, mKv(beta)4

Feature Type

protein coding gene
IDs

MGI:1336208
NCBI Gene: 16499
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr11:69217084-69223867 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 42.51 cM, cytoband B4
Mapping Data

2 experiments

SNPs within 2kb

173 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1336208	protein coding gene	Chr11:69217084-69223868 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018527	protein coding gene	Chr11:69748025-69754805 (+)
A/J	MGP_AJ_G0018496	protein coding gene	Chr11:67125101-67131881 (+)
AKR/J	MGP_AKRJ_G0018465	protein coding gene	Chr11:69124336-69131116 (+)
BALB/cJ	MGP_BALBcJ_G0018467	protein coding gene	Chr11:67444067-67450845 (+)
C3H/HeJ	MGP_C3HHeJ_G0018280	protein coding gene	Chr11:69148960-69155738 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018919	protein coding gene	Chr11:71860673-71867455 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016563	protein coding gene	Chr11:64055319-64062180 (+)
CAST/EiJ	MGP_CASTEiJ_G0017836	protein coding gene	Chr11:69389520-69396309 (+)
CBA/J	MGP_CBAJ_G0018254	protein coding gene	Chr11:75076962-75083740 (+)
DBA/2J	MGP_DBA2J_G0018363	protein coding gene	Chr11:66719300-66726083 (+)
FVB/NJ	MGP_FVBNJ_G0018353	protein coding gene	Chr11:66342714-66349494 (+)
LP/J	MGP_LPJ_G0018434	protein coding gene	Chr11:70318355-70325135 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018376	protein coding gene	Chr11:75694783-75701563 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018960	protein coding gene	Chr11:69383554-69390334 (+)
PWK/PhJ	MGP_PWKPhJ_G0017611	protein coding gene	Chr11:67359064-67365897 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017399	protein coding gene	Chr11:69206053-69212883 (+)
WSB/EiJ	MGP_WSBEiJ_G0017890	protein coding gene	Chr11:69060932-69067712 (+)

Human Ortholog

KCNAB3, potassium voltage-gated channel subfamily A regulatory beta subunit 3

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

KCNAB3, potassium voltage-gated channel subfamily A regulatory beta subunit 3
Synonyms

AKR6A9, KCNA3.1B, KCNA3B, KV-BETA-3
Links

HGNC:6230

NCBI Gene ID: 9196

neXtProt AC: NX_O43448

UniProt: O43448
Chr Location

17p13.1; chr17:7921859-7929856 (-) GRCh38

MGI Vertebrate Homology

Kcnab3 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: KCNAB3
Gene Tree

Kcnab3

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Phenotype Summary

7 phenotypes from 1 allele in 1 genetic background
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Chemically induced (other)

1
Endonuclease-mediated

1
Targeted

4
Genomic Mutations

1 involving Kcnab3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

16 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

11
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

762
Tissues

46
cDNA Data

16
Literature Summary

7

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase kcnab3

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All Sequences

42
RefSeq

2
UniProt

5
CCDS

CCDS24890.1

Ensembl

ENSMUSG00000018470 (Evidence)
NCBI Gene

16499

			Length	Strain/Species	Flank
genomic	16499	NCBI Gene Model \| MGI Sequence Detail	6784	C57BL/6J	± kb
transcript	NM_010599	RefSeq \| MGI Sequence Detail	2537	C57BL/6
polypeptide	P97382	UniProt \| EBI \| MGI Sequence Detail	249	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000009253 voltage-gated potassium channel subunit beta-3

(term hierarchy)
EC

1.1.1.-
InterPro Domains

IPR023210 NADP-dependent oxidoreductase domain

IPR036812 NADP-dependent oxidoreductase domain superfamily

IPR005983 Potassium channel, voltage-dependent, beta subunit, KCNAB

IPR005402 Potassium channel, voltage-dependent, beta subunit, KCNAB3

IPR005399 Potassium channel, voltage-dependent, beta subunit, KCNAB-related

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All nucleic 17

cDNA 16

Primer pair 1

Microarray probesets 5

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MGD-MRK-38198, MGI:109154, MGI:2442514

Summaries

All 47

Developmental Gene Expression 7

Gene Ontology 6

Phenotypes 12
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Kcnab3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr102429	Chr11:69216385-69216410 (+)	-686 bp
Tssr102430	Chr11:69217078-69217101 (+)	6 bp
Tssr102431	Chr11:69217110-69217140 (+)	41 bp
Tssr102432	Chr11:69217143-69217165 (+)	70 bp
Tssr102433	Chr11:69217172-69217181 (+)	93 bp
Tssr102434	Chr11:69217494-69217507 (+)	417 bp
Tssr102435	Chr11:69217522-69217542 (+)	448 bp
Tssr102436	Chr11:69218686-69218694 (+)	1,606 bp
Tssr102437	Chr11:69222191-69222199 (+)	5,111 bp
Tssr102438	Chr11:69222263-69222277 (+)	5,186 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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