About   Help   FAQ
Slc30a3 Gene Detail
Summary
  • Symbol
    Slc30a3
  • Name
    solute carrier family 30 (zinc transporter), member 3
  • Synonyms
    Znt3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1345280
    NCBI Gene: 22784
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:31243450-31265576 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 16.97 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    588 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    3
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1345280
 protein coding gene Chr5:31243450-31265581 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029408
 protein coding gene Chr5:29062331-29090563 (-)
A/J MGP_AJ_G0029374
 protein coding gene Chr5:28113132-28135621 (-)
AKR/J MGP_AKRJ_G0029325
 protein coding gene Chr5:29268106-29291900 (-)
BALB/cJ MGP_BALBcJ_G0029385
 protein coding gene Chr5:28630254-28653847 (-)
C3H/HeJ MGP_C3HHeJ_G0029106
 protein coding gene Chr5:29278384-29301032 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029838
 protein coding gene Chr5:30867199-30895511 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027076
 protein coding gene Chr5:25580274-25603020 (-)
CAST/EiJ MGP_CASTEiJ_G0028516
 protein coding gene Chr5:28362204-28386541 (-)
CBA/J MGP_CBAJ_G0029074
 protein coding gene Chr5:31431563-31456409 (-)
DBA/2J MGP_DBA2J_G0029223
 protein coding gene Chr5:28289954-28315434 (-)
FVB/NJ MGP_FVBNJ_G0029181
 protein coding gene Chr5:27707562-27730234 (-)
LP/J MGP_LPJ_G0029308
 protein coding gene Chr5:29519438-29545027 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029210
 protein coding gene Chr5:32305817-32328883 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029872
 protein coding gene Chr5:28771569-28798435 (-)
PWK/PhJ MGP_PWKPhJ_G0028241
 protein coding gene Chr5:27413424-27437484 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028071
 protein coding gene Chr5:28147545-28170361 (-)
WSB/EiJ MGP_WSBEiJ_G0028597
 protein coding gene Chr5:28837016-28860542 (-)



Homology
more
  • Human Ortholog
    SLC30A3, solute carrier family 30 member 3
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLC30A3, solute carrier family 30 member 3
  • Synonyms
    ZNT3
  • Links
    NCBI Gene ID: 7781
    neXtProt AC: NX_Q99726
    UniProt: Q99726

  • Chr Location
    2p23.3; chr2:27253684-27275817 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 2 genetic backgrounds
    2 phenotypes from multigenic genotypes
    80 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
While zinc is absent from synaptic vesicles in homozygous null mice, inactivation of this locus does not affect brain morphology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    35
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    918
  • Tissues
    81
  • cDNA Data
    19
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 22784 NCBI Gene Model | MGI Sequence Detail 22127 C57BL/6J ±  kb
    transcript NM_001425462 RefSeq | MGI Sequence Detail 2049 C57BL/6  
    polypeptide P97441 UniProt | EBI | MGI Sequence Detail 388 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      9 Sequences
    • Protein Ontology
      PR:000015076 probable proton-coupled zinc antiporter SLC30A3
      (term hierarchy)
    • InterPro Domains
      IPR050681 Cation Diffusion Facilitator/SLC30A
      IPR002524 Cation efflux protein
      IPR036837 Cation efflux protein, cytoplasmic domain superfamily
      IPR027469 Cation efflux transmembrane domain superfamily
    • GlyGen
      P97441 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 21
      Genomic 1
      cDNA 19
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-36577, MGI:107997
    References
    more
    • Summaries
      All 127
      Developmental Gene Expression 9
      Diseases 1
      Gene Ontology 13
      Phenotypes 80
    • Earliest
      J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
    • Latest
      J:354511 Manning A, et al., Trans-synaptic Association of Vesicular Zinc Transporter 3 and Shank3 Supports Synapse-Specific Dendritic Spine Structure and Function in the Mouse Auditory Cortex. J Neurosci. 2024 Jul 10;44(28)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory