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Anpep Gene Detail
Summary
  • Symbol
    Anpep
  • Name
    alanyl aminopeptidase, membrane
  • Synonyms
    aminopeptidase N, Apn, Cd13
  • Feature Type
    protein coding gene
  • IDs
    MGI:5000466
    NCBI Gene: 16790
  • Alliance
    gene page
  • Transcription Start Sites
    55 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:79471551-79497958 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 45.19 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    656 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_5000466
 protein coding gene Chr7:79471551-79510807 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032398
 protein coding gene Chr7:81734634-81774498 (-)
A/J MGP_AJ_G0032377
 protein coding gene Chr7:79845092-79883960 (-)
AKR/J MGP_AKRJ_G0032313
 protein coding gene Chr7:81566807-81605130 (-)
BALB/cJ MGP_BALBcJ_G0032389
 protein coding gene Chr7:79533318-79570757 (-)
C3H/HeJ MGP_C3HHeJ_G0032102
 protein coding gene Chr7:82210312-82254708 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032881
 protein coding gene Chr7:84942089-84984675 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029889
 protein coding gene Chr7:82374827-82414216 (-)
CAST/EiJ MGP_CASTEiJ_G0031430
 protein coding gene Chr7:73090947-73130590 (-)
CBA/J MGP_CBAJ_G0032068
 protein coding gene Chr7:87784165-87821358 (-)
DBA/2J MGP_DBA2J_G0032223
 protein coding gene Chr7:78407579-78444914 (-)
FVB/NJ MGP_FVBNJ_G0032178
 protein coding gene Chr7:78320825-78359356 (-)
LP/J MGP_LPJ_G0032304
 protein coding gene Chr7:82989743-83027788 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032215
 protein coding gene Chr7:87943977-87985248 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032899
 protein coding gene Chr7:81003195-81043114 (-)
PWK/PhJ MGP_PWKPhJ_G0031150
 protein coding gene Chr7:71584113-71624603 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030991
 protein coding gene Chr7:68010599-68047258 (-)
WSB/EiJ MGP_WSBEiJ_G0031548
 protein coding gene Chr7:81326322-81366456 (-)



Homology
more
  • Human Ortholog
    ANPEP, alanyl aminopeptidase, membrane
  • Vertebrate Orthologs
    6
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ANPEP, alanyl aminopeptidase, membrane
  • Synonyms
    AP-M, AP-N, APN, CD13, GP150, hAPN, LAP1, P150, PEPN
  • Links
    NCBI Gene ID: 290
    neXtProt AC: NX_P15144
    UniProt: P15144

  • Chr Location
    15q26.1; chr15:89784895-89815401 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 4 alleles in 5 genetic backgrounds
    34 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for different knock-out alleles exhibit an increase in CD4+ thymocytes, altered macrophage adhesion, pathological neovascularization and/or altered mammary gland morphology during gestation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    26
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1136
  • Tissues
    218
  • cDNA Data
    117
  • Literature Summary
    23
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16790 NCBI Gene Model | MGI Sequence Detail 26408 C57BL/6J ±  kb
    transcript NM_008486 RefSeq | MGI Sequence Detail 3813 C57BL/6  
    polypeptide P97449 UniProt | EBI | MGI Sequence Detail 966 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 120
      cDNA 118
      Primer pair 1
      Other 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 102
      Developmental Gene Expression 23
      Gene Ontology 7
      Phenotypes 34
    • Earliest
      J:5601 Womack JE, et al., Genetic variation of an intestinal leucine arylaminopeptidase (Lap-1) in the mouse and its location on chromosome 9. Biochem Genet. 1975 Oct;13(9-10):511-8
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/29/2024
    MGI 6.24     		The Jackson Laboratory