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Bop1 Gene Detail
Summary
  • Symbol
    Bop1
  • Name
    block of proliferation 1
  • Synonyms
    Erb1p, mKIAA0124
  • Feature Type
    protein coding gene
  • IDs
    MGI:1334460
    NCBI Gene: 12181
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:76337188-76361449 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 35.91 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    454 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1334460
 protein coding gene Chr15:76337188-76361477 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021992
 protein coding gene Chr15:76527734-76551995 (-)
A/J MGP_AJ_G0021950
 protein coding gene Chr15:73742008-73766840 (-)
AKR/J MGP_AKRJ_G0021933
 protein coding gene Chr15:75741975-75766253 (-)
BALB/cJ MGP_BALBcJ_G0021959
 protein coding gene Chr15:73769701-73794356 (-)
C3H/HeJ MGP_C3HHeJ_G0021731
 protein coding gene Chr15:75789456-75814908 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022399
 protein coding gene Chr15:79394455-79418719 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019928
 protein coding gene Chr15:70403589-70427891 (-)
CAST/EiJ MGP_CASTEiJ_G0021250
 protein coding gene Chr15:76591663-76617406 (-)
CBA/J MGP_CBAJ_G0021698
 protein coding gene Chr15:81897830-81922258 (-)
DBA/2J MGP_DBA2J_G0021823
 protein coding gene Chr15:73279077-73303470 (-)
FVB/NJ MGP_FVBNJ_G0021803
 protein coding gene Chr15:72332599-72358857 (-)
LP/J MGP_LPJ_G0021894
 protein coding gene Chr15:76626093-76654156 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021828
 protein coding gene Chr15:87233069-87257424 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022419
 protein coding gene Chr15:75993500-76019246 (-)
PWK/PhJ MGP_PWKPhJ_G0020991
 protein coding gene Chr15:73441152-73466502 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020831
 protein coding gene Chr15:75708811-75733330 (-)
WSB/EiJ MGP_WSBEiJ_G0021302
 protein coding gene Chr15:76097437-76121766 (-)



Homology
more
  • Human Ortholog
    BOP1, BOP1 ribosomal biogenesis factor
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    BOP1, BOP1 ribosomal biogenesis factor
  • Links
    NCBI Gene ID: 23246
    neXtProt AC: NX_Q14137
    UniProt: Q14137

  • Chr Location
    8q24.3; chr8:144262045-144291438 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    29 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    32
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    762
  • Tissues
    53
  • cDNA Data
    118
  • Literature Summary
    5
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 12181 NCBI Gene Model | MGI Sequence Detail 24262 C57BL/6J ±  kb
transcript NM_013481 RefSeq | MGI Sequence Detail 2464 ZRU/MplStud  
polypeptide P97452 UniProt | EBI | MGI Sequence Detail 732 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 122
    Genomic 2
    cDNA 120

    Microarray probesets 3
Other
Accession IDs
less
MGI:2146135, MGI:2146201, MGI:2146316
References
more
  • Summaries
    All 71
    Developmental Gene Expression 5
    Diseases 1
    Gene Ontology 11
    Phenotypes 29
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:345956 Li J, et al., PDGF-C promotes cell proliferation partially via downregulating BOP1. Cell Biol Int. 2023 Dec;47(12):1942-1949
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory