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Nog Gene Detail
Summary
  • Symbol
    Nog
  • Name
    noggin
  • Feature Type
    protein coding gene
  • IDs
    MGI:104327
    NCBI Gene: 18121
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:89191464-89193158 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 11, 54.34 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    27 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104327
protein coding gene Chr11:89191464-89193385 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018932
protein coding gene Chr11:91081692-91083322 (-)
A/J MGP_AJ_G0018900
protein coding gene Chr11:87525712-87527406 (-)
AKR/J MGP_AKRJ_G0018870
protein coding gene Chr11:90218448-90220142 (-)
BALB/cJ MGP_BALBcJ_G0018873
protein coding gene Chr11:87954115-87955767 (-)
C3H/HeJ MGP_C3HHeJ_G0018687
protein coding gene Chr11:90235239-90236933 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019325
protein coding gene Chr11:93904005-93905699 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016956
protein coding gene Chr11:84561721-84563408 (-)
CAST/EiJ MGP_CASTEiJ_G0018242
protein coding gene Chr11:90958957-90960653 (-)
CBA/J MGP_CBAJ_G0018658
protein coding gene Chr11:97868666-97870360 (-)
DBA/2J MGP_DBA2J_G0018766
protein coding gene Chr11:87078666-87080360 (-)
FVB/NJ MGP_FVBNJ_G0018755
protein coding gene Chr11:86578854-86580548 (-)
LP/J MGP_LPJ_G0018836
protein coding gene Chr11:91601761-91603405 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018782
protein coding gene Chr11:97757777-97759471 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019365
protein coding gene Chr11:90416199-90417876 (-)
PWK/PhJ MGP_PWKPhJ_G0018012
protein coding gene Chr11:87952757-87954450 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017802
protein coding gene Chr11:90010825-90012516 (-)
WSB/EiJ MGP_WSBEiJ_G0018291
protein coding gene Chr11:90314893-90316587 (-)



Homology
more
  • Human Ortholog
    NOG, noggin
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NOG, noggin
  • Synonyms
    SYM1, SYNS1, SYNS1A
  • Links
    NCBI Gene ID: 9241
    neXtProt AC: NX_Q13253
    UniProt: Q13253

  • Chr Location
    17q22; chr17:56593699-56595611 (+)  GRCh38

Human Diseases
more
  • Diseases
    1 with Nog mouse models; 9 with human NOG associations

Human Disease Mouse Models
      
IDs
View 1 model
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    142 phenotypes from 5 alleles in 18 genetic backgrounds
    57 phenotypes from multigenic genotypes
    93 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit failed closure of neural tube, exencephaly, wide club-shaped limbs, loss of tail vertebrae, shortened body axis, abnormal cartilage condensations, and lethality at birth.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000048616 Ensembl Gene Model | MGI Sequence Detail 1695 C57BL/6J ±  kb
    transcript ENSMUST00000061728 Ensembl | MGI Sequence Detail 1695 Not Applicable  
    polypeptide ENSMUSP00000061427 Ensembl | MGI Sequence Detail 232 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 50
      Genomic 1
      cDNA 17
      Primer pair 8
      Other 24

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-25655
    References
    more
    • Summaries
      All 284
      Developmental Gene Expression 171
      Diseases 3
      Gene Ontology 31
      Phenotypes 93
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:348857 Li Z, et al., BMP7 expression in mammalian cortical radial glial cells increases the length of the neurogenic period. Protein Cell. 2024 Jan 3;15(1):21-35

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    11/19/2024
    MGI 6.24
    The Jackson Laboratory