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Gclc Gene Detail
Summary
  • Symbol
    Gclc
  • Name
    glutamate-cysteine ligase, catalytic subunit
  • Synonyms
    D9Wsu168e, gamma GCS-HS, Glclc, GLCL-H
  • Feature Type
    protein coding gene
  • IDs
    MGI:104990
    NCBI Gene: 14629
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:77661817-77701767 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 43.36 cM, cytoband D-E
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1117 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104990
 protein coding gene Chr9:77661817-77701771 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035054
 protein coding gene Chr9:78205494-78246989 (+)
A/J MGP_AJ_G0035035
 protein coding gene Chr9:75475129-75515443 (+)
AKR/J MGP_AKRJ_G0034964
 protein coding gene Chr9:77265874-77310280 (+)
BALB/cJ MGP_BALBcJ_G0035027
 protein coding gene Chr9:75156002-75196162 (+)
C3H/HeJ MGP_C3HHeJ_G0034736
 protein coding gene Chr9:77785749-77830974 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035545
 protein coding gene Chr9:80296095-80338859 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032456
 protein coding gene Chr9:74721080-74760959 (+)
CAST/EiJ MGP_CASTEiJ_G0034058
 protein coding gene Chr9:78127665-78168482 (+)
CBA/J MGP_CBAJ_G0034708
 protein coding gene Chr9:83061884-83102463 (+)
DBA/2J MGP_DBA2J_G0034868
 protein coding gene Chr9:75130028-75170776 (+)
FVB/NJ MGP_FVBNJ_G0034810
 protein coding gene Chr9:74382827-74422724 (+)
LP/J MGP_LPJ_G0034949
 protein coding gene Chr9:78434689-78477003 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034851
 protein coding gene Chr9:84281334-84332627 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035568
 protein coding gene Chr9:77447266-77487368 (+)
PWK/PhJ MGP_PWKPhJ_G0033762
 protein coding gene Chr9:75374532-75414487 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033595
 protein coding gene Chr9:77688742-77728485 (+)
WSB/EiJ MGP_WSBEiJ_G0034170
 protein coding gene Chr9:77363285-77403793 (+)



Homology
more
  • Human Ortholog
    GCLC, glutamate-cysteine ligase catalytic subunit
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GCLC, glutamate-cysteine ligase catalytic subunit
  • Synonyms
    CNSHA7, GCL, GCS, GLCL, GLCLC
  • Links
    NCBI Gene ID: 2729
    neXtProt AC: NX_P48506
    UniProt: P48506

  • Chr Location
    6p12.1; chr6:53497341-53616970 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Gclc mouse models; 4 with human GCLC associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    27 phenotypes from 4 alleles in 5 genetic backgrounds
    1 images
    39 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant mice are embryonic lethal. One model shows lethality before E13 while another shows lethality between E7.5-E8.5. In this second model, embryos are arrested at the egg cylinder stage, fail to gastrulate, do not form mesoderm, and exhibitincreased apoptosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    76
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1234
  • Tissues
    246
  • cDNA Data
    121
  • Literature Summary
    22
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000032350 Ensembl Gene Model | MGI Sequence Detail 39951 C57BL/6J ±  kb
    transcript ENSMUST00000034905 Ensembl | MGI Sequence Detail 3423 Not Applicable  
    polypeptide ENSMUSP00000034905 Ensembl | MGI Sequence Detail 637 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000007897 glutamate--cysteine ligase catalytic subunit
      (term hierarchy)
    • EC
      6.3.2.2
    • InterPro Domains
      IPR004308 Glutamate-cysteine ligase catalytic subunit
      IPR014746 Glutamine synthetase/guanido kinase, catalytic domain
    • GlyGen
      P97494 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 134
      Genomic 1
      cDNA 123
      Primer pair 9
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-31063, MGD-MRK-36456, MGI:107879
    References
    more
    • Summaries
      All 106
      Developmental Gene Expression 22
      Diseases 1
      Gene Ontology 15
      Phenotypes 39
    • Earliest
      J:12013 Russell LB, Definition of functional units in a small chromosomal segment of the mouse and its use in interpreting the nature of radiation-induced mutations. Mutat Res. 1971 Jan;11(1):107-23
    • Latest
      J:352152 Asantewaa G, et al., Glutathione synthesis in the mouse liver supports lipid abundance through NRF2 repression. Nat Commun. 2024 Jul 21;15(1):6152
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/29/2024
    MGI 6.24     		The Jackson Laboratory