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Tep1 Gene Detail
Summary
  • Symbol
    Tep1
  • Name
    telomerase associated protein 1
  • Synonyms
    Tp1
  • Feature Type
    protein coding gene
  • IDs
    MGI:109573
    NCBI Gene: 21745
  • Alliance
    gene page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:51061516-51108017 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 26.26 cM, cytoband C2-D1
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1178 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109573
 protein coding gene Chr14:51061513-51108036 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021259
 protein coding gene Chr14:44774417-44824801 (-)
A/J MGP_AJ_G0021213
 protein coding gene Chr14:43439268-43486416 (-)
AKR/J MGP_AKRJ_G0021189
 protein coding gene Chr14:45068728-45125084 (-)
BALB/cJ MGP_BALBcJ_G0021216
 protein coding gene Chr14:43551912-43600893 (-)
C3H/HeJ MGP_C3HHeJ_G0020998
 protein coding gene Chr14:44895828-44945185 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021652
 protein coding gene Chr14:46601330-46651623 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019205
 protein coding gene Chr14:42778923-42823668 (-)
CAST/EiJ MGP_CASTEiJ_G0020522
 protein coding gene Chr14:41960209-42008504 (-)
CBA/J MGP_CBAJ_G0020965
 protein coding gene Chr14:48086804-48139754 (-)
DBA/2J MGP_DBA2J_G0021089
 protein coding gene Chr14:43334876-43381669 (-)
FVB/NJ MGP_FVBNJ_G0021070
 protein coding gene Chr14:42962027-43009032 (-)
LP/J MGP_LPJ_G0021157
 protein coding gene Chr14:45054786-45104927 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021098
 protein coding gene Chr14:47562137-47610787 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021682
 protein coding gene Chr14:44566321-44616628 (-)
PWK/PhJ MGP_PWKPhJ_G0020272
 protein coding gene Chr14:40233177-40280170 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020097
 protein coding gene Chr14:40724165-40773390 (-)
WSB/EiJ MGP_WSBEiJ_G0020575
 protein coding gene Chr14:44755447-44803368 (-)



Homology
more
  • Human Ortholog
    TEP1, telomerase associated protein 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TEP1, telomerase associated protein 1
  • Synonyms
    p240, TLP1, TP1, TROVE1, VAULT2
  • Links
    NCBI Gene ID: 7011
    neXtProt AC: NX_Q99973
    UniProt: Q99973

  • Chr Location
    14q11.2; chr14:20365667-20413501 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human TEP1 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 2 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a disruption in this gene show no obvious phenotype. No changes are seen in telomerase activity or telomere length.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    24
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    742
  • Tissues
    2
  • cDNA Data
    53
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000006281 Ensembl Gene Model | MGI Sequence Detail 46502 C57BL/6J ±  kb
transcript ENSMUST00000006444 Ensembl | MGI Sequence Detail 8171 Not Applicable  
polypeptide ENSMUSP00000006444 Ensembl | MGI Sequence Detail 2629 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 58
    Genomic 1
    cDNA 56
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-39572
References
more
  • Summaries
    All 47
    Developmental Gene Expression 1
    Gene Ontology 10
    Phenotypes 15
  • Earliest
    J:21192 Joly EC, et al., TRiC-P5, a novel TCP1-related protein, is localized in the cytoplasm and in the nuclear matrix. J Cell Sci. 1994 Oct;107(Pt 10):2851-9
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory