About   Help   FAQ
Ihh Gene Detail
Summary
  • Symbol
    Ihh
  • Name
    Indian hedgehog
  • Feature Type
    protein coding gene
  • IDs
    MGI:96533
    NCBI Gene: 16147
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:74984474-74990831 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 38.55 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    223 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96533
 protein coding gene Chr1:74984474-74990831 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016168
 protein coding gene Chr1:75563286-75569647 (-)
A/J MGP_AJ_G0016151
 protein coding gene Chr1:72929172-72935541 (-)
AKR/J MGP_AKRJ_G0016108
 protein coding gene Chr1:74944172-74950537 (-)
BALB/cJ MGP_BALBcJ_G0016106
 protein coding gene Chr1:72990233-72996585 (-)
C3H/HeJ MGP_C3HHeJ_G0015937
 protein coding gene Chr1:75288344-75294713 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016559
 protein coding gene Chr1:78503714-78510098 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014280
 protein coding gene Chr1:68492361-68498788 (-)
CAST/EiJ MGP_CASTEiJ_G0015521
 protein coding gene Chr1:74617483-74623836 (-)
CBA/J MGP_CBAJ_G0015910
 protein coding gene Chr1:81062394-81068792 (-)
DBA/2J MGP_DBA2J_G0016011
 protein coding gene Chr1:72246641-72253010 (-)
FVB/NJ MGP_FVBNJ_G0016014
 protein coding gene Chr1:71444139-71450526 (-)
LP/J MGP_LPJ_G0016083
 protein coding gene Chr1:76681567-76687953 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016034
 protein coding gene Chr1:84435279-84441660 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016606
 protein coding gene Chr1:75020051-75026397 (-)
PWK/PhJ MGP_PWKPhJ_G0015308
 protein coding gene Chr1:71710331-71716684 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015086
 protein coding gene Chr1:74386494-74392861 (-)
WSB/EiJ MGP_WSBEiJ_G0015583
 protein coding gene Chr1:74836664-74843050 (-)



Homology
more
  • Human Ortholog
    IHH, Indian hedgehog signaling molecule
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IHH, Indian hedgehog signaling molecule
  • Synonyms
    BDA1, HHG2
  • Links
    NCBI Gene ID: 3549
    neXtProt AC: NX_Q14623
    UniProt: Q14623

  • Chr Location
    2q35; chr2:219054424-219060921 (-)  GRCh38
Human Diseases
more
  • Diseases
    3 with Ihh mouse models; 4 with human IHH associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
 View 1 model
IDs
 View 1 model
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    70 phenotypes from 3 alleles in 5 genetic backgrounds
    24 phenotypes from multigenic genotypes
    87 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes die before or immediately after birth due to respiratory failure, exhibiting limb dwarfism associated with reduced chondrocyte proliferation, ectopic maturation of chondrocytes, and a failure of osteoblast development in endochondral bones.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    100
  • GO References
    31
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1597
  • Tissues
    358
  • cDNA Data
    33
  • Literature Summary
    450
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16147 NCBI Gene Model | MGI Sequence Detail 6358 C57BL/6J ±  kb
    transcript NM_010544 RefSeq | MGI Sequence Detail 2476 ZRU/MplStud  
    polypeptide P97812 UniProt | EBI | MGI Sequence Detail 411 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 112
      cDNA 40
      Primer pair 29
      Other 43

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-11343
    References
    more
    • Summaries
      All 570
      Developmental Gene Expression 450
      Diseases 2
      Gene Ontology 31
      Phenotypes 87
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:353623 Almubarak A, et al., FOXC1 and FOXC2 regulate growth plate chondrocyte maturation towards hypertrophy in the embryonic mouse limb skeleton. Development. 2024 Aug 15;151(16)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    10/29/2024
    MGI 6.24     		The Jackson Laboratory