Casp7 MGI Mouse Gene Detail - MGI:109383

Symbol

Casp7
Name

caspase 7
Synonyms

caspase-7, CMH-1, ICE-IAP3, Mch3

Feature Type

protein coding gene
IDs

MGI:109383
NCBI Gene: 12369
Alliance

gene page
Transcription Start Sites

12 TSS

Sequence Map

Chr19:56385561-56430776 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 51.84 cM
Mapping Data

3 experiments

SNPs within 2kb

1547 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_109383	protein coding gene	Chr19:56382640-56430780 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0025263	protein coding gene	Chr19:56742971-56790982 (+)
A/J	MGP_AJ_G0025239	protein coding gene	Chr19:53939098-53983490 (+)
AKR/J	MGP_AKRJ_G0025208	protein coding gene	Chr19:55637838-55685614 (+)
BALB/cJ	MGP_BALBcJ_G0025234	protein coding gene	Chr19:54027604-54066860 (+)
C3H/HeJ	MGP_C3HHeJ_G0024994	protein coding gene	Chr19:55880342-55924428 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025677	protein coding gene	Chr19:58108280-58153863 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023089	protein coding gene	Chr19:52868458-52908248 (+)
CAST/EiJ	MGP_CASTEiJ_G0024459	protein coding gene	Chr19:55897443-55937344 (+)
CBA/J	MGP_CBAJ_G0024974	protein coding gene	Chr19:60988506-61037465 (+)
DBA/2J	MGP_DBA2J_G0025106	protein coding gene	Chr19:53733176-53775675 (+)
FVB/NJ	MGP_FVBNJ_G0025067	protein coding gene	Chr19:53436954-53477424 (+)
LP/J	MGP_LPJ_G0025192	protein coding gene	Chr19:56611193-56652269 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025100	protein coding gene	Chr19:60289322-60336878 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025735	protein coding gene	Chr19:55855872-55896865 (+)
PWK/PhJ	MGP_PWKPhJ_G0024207	protein coding gene	Chr19:53686767-53728816 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0024010	protein coding gene	Chr19:54528692-54575594 (+)
WSB/EiJ	MGP_WSBEiJ_G0024529	protein coding gene	Chr19:55992016-56038646 (+)

Human Ortholog

CASP7, caspase 7

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CASP7, caspase 7
Synonyms

CASP-7, CMH-1, ICE-LAP3, LICE2, MCH3
Links

HGNC:1508

NCBI Gene ID: 840

neXtProt AC: NX_P55210

UniProt: P55210
Chr Location

10q25.3; chr10:113679162-113730909 (+) GRCh38

MGI Vertebrate Homology

Casp7 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CASP7
Protein SuperFamily

Caspase_ICE
Gene Tree

Casp7

Diseases

4 with human CASP7 associations

				Human Disease	Mouse Models
				Alzheimer's disease IDs Alzheimer's disease DOID:10652 ICD10CM:G30 ICD9CM:331.0 KEGG:05010 MESH:D000544 NCI:C2866 UMLS_CUI:C0002395
				breast cancer IDs breast cancer DOID:1612 DOID:1648 DOID:4241 ICD10CM:C50 ICD9CM:174.8 MESH:D001943 NCI:C9335 OMIM:114480 UMLS_CUI:C0006142
				colon cancer IDs colon cancer DOID:219 ICD10CM:C18 ICD9CM:153 ICD9CM:153.9 MESH:D003110 NCI:C9242 UMLS_CUI:C0007102
				lung non-small cell carcinoma IDs lung non-small cell carcinoma DOID:3908 EFO:0003060 KEGG:05223 MESH:D002289 NCI:C2926 UMLS_CUI:C0007131

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

3 phenotypes from 2 alleles in 3 genetic backgrounds
8 phenotypes from multigenic genotypes
41 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Endonuclease-mediated

4
Targeted

5
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

17 strains or lines available

Mice homozygous for a targeted mutation have normal appearance, organ morphology and lymphoid development.

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All GO Annotations

47
GO References

14

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

799
Tissues

34
cDNA Data

48
Literature Summary

22

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase casp7

ZFIN casp7

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All Sequences

45
RefSeq

4
UniProt

4
CCDS

CCDS29915.1

Ensembl

ENSMUSG00000025076 (Evidence)
NCBI Gene

12369

			Length	Strain/Species	Flank
genomic	ENSMUSG00000025076	Ensembl Gene Model \| MGI Sequence Detail	45216	C57BL/6J	± kb
transcript	ENSMUST00000026062	Ensembl \| MGI Sequence Detail	2350	Not Applicable
polypeptide	ENSMUSP00000026062	Ensembl \| MGI Sequence Detail	303	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000002316 caspase-7

(term hierarchy)
EC

3.4.22.60
InterPro Domains

IPR029030 Caspase-like domain superfamily

IPR015917 Peptidase C14A, caspase catalytic domain

IPR011600 Peptidase C14, caspase domain

IPR002138 Peptidase C14, caspase non-catalytic subunit p10

IPR001309 Peptidase C14, p20 domain

IPR033139 Peptidase family C14A, cysteine active site

IPR016129 Peptidase family C14A, His active site

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All nucleic 54

Genomic 1

cDNA 48

Primer pair 4

Other 1

Microarray probesets 5

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MGD-MRK-38428, MGI:2147501

Summaries

All 123

Developmental Gene Expression 22

Gene Ontology 14

Phenotypes 41
Earliest

J:38326 Van de Craen M, et al., Characterization of seven murine caspase family members. FEBS Lett. 1997 Feb 10;403(1):61-9
Latest

J:342082 Harvest CK, et al., An innate granuloma eradicates an environmental pathogen using Gsdmd and Nos2. Nat Commun. 2023 Oct 21;14(1):6686

TSS for Casp7:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr157180	Chr19:56385266-56385285 (+)	-285 bp
Tssr5563	Chr19:56385507-56385527 (+)	-44 bp
Tssr157181	Chr19:56385532-56385589 (+)	0 bp
Tssr157182	Chr19:56385647-56385658 (+)	92 bp
Tssr157183	Chr19:56385663-56385697 (+)	119 bp
Tssr157184	Chr19:56405568-56405590 (+)	20,018 bp
Tssr157185	Chr19:56414115-56414126 (+)	28,560 bp
Tssr157186	Chr19:56414148-56414174 (+)	28,600 bp
Tssr157187	Chr19:56414188-56414203 (+)	28,635 bp
Tssr157188	Chr19:56425113-56425144 (+)	39,568 bp
Tssr157189	Chr19:56429623-56429637 (+)	44,069 bp
Tssr157190	Chr19:56429661-56429670 (+)	44,105 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 10/22/2024 MGI 6.24