Jdp2 MGI Mouse Gene Detail - MGI:1932093 - Jun dimerization protein 2

Symbol

Jdp2
Name

Jun dimerization protein 2
Synonyms

Jundm2, TIF

Feature Type

protein coding gene
IDs

MGI:1932093
NCBI Gene: 81703
Alliance

gene page
Transcription Start Sites

12 TSS

Sequence Map

Chr12:85645801-85686652 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 39.74 cM, cytoband D3
Mapping Data

1 experiment

SNPs within 2kb

990 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1932093	protein coding gene	Chr12:85645190-85686652 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019962	protein coding gene	Chr12:86380827-86424985 (+)
A/J	MGP_AJ_G0019919	protein coding gene	Chr12:83104862-83146515 (+)
AKR/J	MGP_AKRJ_G0019895	protein coding gene	Chr12:85356250-85397023 (+)
BALB/cJ	MGP_BALBcJ_G0019899	protein coding gene	Chr12:83445161-83486320 (+)
C3H/HeJ	MGP_C3HHeJ_G0019705	protein coding gene	Chr12:85827580-85869982 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020350	protein coding gene	Chr12:88878516-88922981 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017968	protein coding gene	Chr12:79988280-80028808 (+)
CAST/EiJ	MGP_CASTEiJ_G0019255	protein coding gene	Chr12:80803965-80849446 (+)
CBA/J	MGP_CBAJ_G0019676	protein coding gene	Chr12:92275441-92317933 (+)
DBA/2J	MGP_DBA2J_G0019790	protein coding gene	Chr12:82618482-82659820 (+)
FVB/NJ	MGP_FVBNJ_G0019777	protein coding gene	Chr12:81588307-81629084 (+)
LP/J	MGP_LPJ_G0019864	protein coding gene	Chr12:86255694-86302125 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019816	protein coding gene	Chr12:95113088-95157034 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020383	protein coding gene	Chr12:84961870-85005013 (+)
PWK/PhJ	MGP_PWKPhJ_G0019018	protein coding gene	Chr12:77129903-77172313 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018814	protein coding gene	Chr12:79439281-79485600 (+)
WSB/EiJ	MGP_WSBEiJ_G0019307	protein coding gene	Chr12:85700730-85744340 (+)

Human Ortholog

JDP2, Jun dimerization protein 2

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

JDP2, Jun dimerization protein 2
Synonyms

JUNDM2
Links

HGNC:17546

NCBI Gene ID: 122953

neXtProt AC: NX_Q8WYK2

UniProt: Q8WYK2
Chr Location

14q24.3; chr14:75426943-75474111 (+) GRCh38

MGI Vertebrate Homology

Jdp2 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: JDP2
Gene Tree

Jdp2

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Phenotype Summary

21 phenotypes from 4 alleles in 4 genetic backgrounds
21 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

17
Chemically induced (other)

1
Endonuclease-mediated

4
Gene trapped

6
Targeted

6
Genomic Mutations

1 involving Jdp2
Incidental Mutations

APF
Find Mice (IMSR)

14 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Mice homozygous for a null allele exhibit increased white adipose tissue differentiation, short tail, and enhanced would healing due to increased cell proliferation.

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All GO Annotations

31
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

999
Tissues

95
cDNA Data

6
Literature Summary

9

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA JDP2

ZFIN jdp2b

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All Sequences

50
RefSeq

12
UniProt

4
CCDS

CCDS26060.1

Ensembl

ENSMUSG00000034271 (Evidence)
NCBI Gene

81703

			Length	Strain/Species	Flank
genomic	ENSMUSG00000034271	Ensembl Gene Model \| MGI Sequence Detail	40852	C57BL/6J	± kb
transcript	ENSMUST00000177587	Ensembl \| MGI Sequence Detail	1645	Not Applicable
polypeptide	ENSMUSP00000136823	Ensembl \| MGI Sequence Detail	163	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000009210 Jun dimerization protein 2

(term hierarchy)
InterPro Domains

IPR000837 AP-1 transcription factor

IPR004827 Basic-leucine zipper domain

IPR046347 Basic-leucine zipper domain superfamily

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All nucleic 7

cDNA 6

Primer pair 1

Microarray probesets 3

Summaries

All 53

Developmental Gene Expression 9

Gene Ontology 5

Phenotypes 21
Earliest

J:67261 Jin C, et al., Identification of mouse Jun dimerization protein 2 as a novel repressor of ATF-2. FEBS Lett. 2001 Jan 26;489(1):34-41
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Jdp2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr114413	Chr12:85645014-85645049 (+)	-769 bp
Tssr114414	Chr12:85645061-85645082 (+)	-729 bp
Tssr114415	Chr12:85645176-85645212 (+)	-607 bp
Tssr114416	Chr12:85645374-85645381 (+)	-423 bp
Tssr114417	Chr12:85645481-85645509 (+)	-306 bp
Tssr114418	Chr12:85645821-85645864 (+)	42 bp
Tssr114419	Chr12:85646124-85646136 (+)	329 bp
Tssr114420	Chr12:85646162-85646181 (+)	371 bp
Tssr114421	Chr12:85655066-85655078 (+)	9,271 bp
Tssr114422	Chr12:85655096-85655114 (+)	9,304 bp
Tssr114423	Chr12:85661161-85661164 (+)	15,362 bp
Tssr114424	Chr12:85686315-85686334 (+)	40,524 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 10/29/2024 MGI 6.24