Atp8b2 MGI Mouse Gene Detail - MGI:1859660 - ATPase, class I, type 8B, member 2

Symbol

Atp8b2
Name

ATPase, class I, type 8B, member 2
Synonyms

Id

Feature Type

protein coding gene
IDs

MGI:1859660
NCBI Gene: 54667
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr3:89846795-89870645 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 39.19 cM, cytoband F2
Mapping Data

1 experiment

SNPs within 2kb

635 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1859660	protein coding gene	Chr3:89846788-89870815 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0027449	protein coding gene	Chr3:90193582-90218814 (-)
A/J	MGP_AJ_G0027413	protein coding gene	Chr3:87205970-87230153 (-)
AKR/J	MGP_AKRJ_G0027377	protein coding gene	Chr3:89334174-89360242 (-)
BALB/cJ	MGP_BALBcJ_G0027422	protein coding gene	Chr3:87168996-87193332 (-)
C3H/HeJ	MGP_C3HHeJ_G0027164	protein coding gene	Chr3:89515886-89539913 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0027868	protein coding gene	Chr3:93580147-93604190 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025220	protein coding gene	Chr3:82685530-82709661 (-)
CAST/EiJ	MGP_CASTEiJ_G0026610	protein coding gene	Chr3:89888471-89912319 (-)
CBA/J	MGP_CBAJ_G0027138	protein coding gene	Chr3:96820391-96849510 (-)
DBA/2J	MGP_DBA2J_G0027276	protein coding gene	Chr3:86576704-86602373 (-)
FVB/NJ	MGP_FVBNJ_G0027244	protein coding gene	Chr3:84912949-84937217 (-)
LP/J	MGP_LPJ_G0027385	protein coding gene	Chr3:91266227-91290084 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027264	protein coding gene	Chr3:103005265-103031796 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027927	protein coding gene	Chr3:89074938-89101426 (-)
PWK/PhJ	MGP_PWKPhJ_G0026344	protein coding gene	Chr3:86467781-86492264 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0026163	protein coding gene	Chr3:88257691-88283415 (-)
WSB/EiJ	MGP_WSBEiJ_G0026692	protein coding gene	Chr3:89479185-89504072 (-)

Human Ortholog

ATP8B2, ATPase phospholipid transporting 8B2

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ATP8B2, ATPase phospholipid transporting 8B2
Synonyms

ATPID
Links

HGNC:13534

NCBI Gene ID: 57198

neXtProt AC: NX_P98198

UniProt: P98198
Chr Location

1q21.3; chr1:154325525-154351304 (+) GRCh38

MGI Vertebrate Homology

Atp8b2 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: ATP8B2
Gene Tree

Atp8b2

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References

1 with disease annotations

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

1
Radiation induced

1
Targeted

2
Genomic Mutations

2 involving Atp8b2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

53 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

20
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

943
Tissues

30
cDNA Data

89
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

70
RefSeq

6
UniProt

10
CCDS

CCDS38497.2, CCDS89658.1

Ensembl

ENSMUSG00000060671 (Evidence)
NCBI Gene

54667

			Length	Strain/Species	Flank
genomic	54667	NCBI Gene Model \| MGI Sequence Detail	23851	C57BL/6J	± kb
transcript	NM_001368650	RefSeq \| MGI Sequence Detail	5520	C57BL/6
polypeptide	P98199	UniProt \| EBI \| MGI Sequence Detail	1209	Not Applicable

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UniProt

10 Sequences
Protein Ontology

PR:000031717 phospholipid-transporting ATPase ID

(term hierarchy)
EC

7.6.2.1
InterPro Domains

IPR036412 HAD-like superfamily

IPR023214 HAD superfamily

IPR001757 P-type ATPase

IPR008250 P-type ATPase, A domain superfamily

IPR032630 P-type ATPase, C-terminal

IPR023299 P-type ATPase, cytoplasmic domain N

IPR044492 P-type ATPase, haloacid dehalogenase domain

IPR032631 P-type ATPase, N-terminal

IPR018303 P-type ATPase, phosphorylation site

IPR006539 P-type ATPase, subfamily IV

IPR023298 P-type ATPase, transmembrane domain superfamily

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All nucleic 89

cDNA 89

Microarray probesets 4

Summaries

All 42

Developmental Gene Expression 2

Diseases 1

Gene Ontology 8

Phenotypes 14
Earliest

J:29458 Shoji W, et al., MIDA1, a protein associated with Id, regulates cell growth. J Biol Chem. 1995 Oct 20;270(42):24818-25
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Atp8b2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr34173	Chr3:89870611-89870662 (-)	8 bp
Tssr34172	Chr3:89870580-89870593 (-)	58 bp
Tssr34171	Chr3:89867869-89867924 (-)	2,748 bp
Tssr34170	Chr3:89867847-89867864 (-)	2,789 bp
Tssr34169	Chr3:89866453-89866463 (-)	4,187 bp
Tssr34168	Chr3:89866425-89866437 (-)	4,214 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24