Cebpd MGI Mouse Gene Detail - MGI:103573 - CCAAT/enhancer binding protein delta

Symbol

Cebpd
Name

CCAAT/enhancer binding protein delta

Feature Type

protein coding gene
IDs

MGI:103573
NCBI Gene: 12609
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr16:15705150-15707409 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 16, 10.09 cM
Mapping Data

5 experiments

SNPs within 2kb

117 from dbSNP Build 142
Strain Annotations

18
RFLP

4

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_103573	protein coding gene	Chr16:15705150-15708895 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0036407	pseudogene	Chr16:12982740-12983920 (+)
A/J	MGP_AJ_G0036391	pseudogene	Chr16:12288556-12289736 (+)
AKR/J	MGP_AKRJ_G0036342	pseudogene	Chr16:12799105-12800285 (+)
BALB/cJ	MGP_BALBcJ_G0036384	pseudogene	Chr16:12448601-12449781 (+)
C3H/HeJ	MGP_C3HHeJ_G0036078	pseudogene	Chr16:12895946-12897126 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0036893	pseudogene	Chr16:13140283-13141463 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0034007	pseudogene	Chr16:12418216-12419394 (+)
CAST/EiJ	MGP_CASTEiJ_G0035275	pseudogene	Chr16:12839186-12840367 (+)
CBA/J	MGP_CBAJ_G0036050	pseudogene	Chr16:13730588-13731768 (+)
DBA/2J	MGP_DBA2J_G0036223	pseudogene	Chr16:12239917-12241097 (+)
FVB/NJ	MGP_FVBNJ_G0036177	pseudogene	Chr16:12278965-12280145 (+)
LP/J	MGP_LPJ_G0036276	pseudogene	Chr16:12770718-12771898 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0036180	pseudogene	Chr16:13414848-13416028 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0037003	pseudogene	Chr16:12743001-12744181 (+)
PWK/PhJ	MGP_PWKPhJ_G0034975	pseudogene	Chr16:12493647-12494828 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0034792	pseudogene	Chr16:12724518-12725699 (+)
WSB/EiJ	MGP_WSBEiJ_G0035466	pseudogene	Chr16:12741943-12743123 (+)

Human Ortholog

CEBPD, CCAAT enhancer binding protein delta

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CEBPD, CCAAT enhancer binding protein delta
Synonyms

C/EBP-delta, CELF, CRP3, NF-IL6-beta
Links

HGNC:1835

NCBI Gene ID: 1052

neXtProt AC: NX_P49716

UniProt: P49716
Chr Location

8q11.21; chr8:47736913-47738164 (-) GRCh38

MGI Vertebrate Homology

Cebpd stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CEBPD
Protein SuperFamily

CCAAT/enhancer-binding
Gene Tree

Cebpd

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Phenotype Summary

16 phenotypes from 2 alleles in 3 genetic backgrounds
8 phenotypes from multigenic genotypes
39 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Endonuclease-mediated

3
Targeted

2
Find Mice (IMSR)

9 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele are viable and healthy and perform normally on several behavioral tasks, but display enhanced contextual fear conditioning. Mice homozygous for a second knock-out allele exhibit nearly normal or only slightly impaired adipocyte differentiation.

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All GO Annotations

30
GO References

15

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

913
Tissues

160
cDNA Data

41
Literature Summary

25

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cebpd

ZFIN cebpd

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All Sequences

39
RefSeq

2
UniProt

4
CCDS

CCDS84207.1

Ensembl

ENSMUSG00000071637 (Evidence)
NCBI Gene

12609

			Length	Strain/Species	Flank
genomic	12609	NCBI Gene Model \| MGI Sequence Detail	2260	C57BL/6J	± kb
transcript	NM_007679	RefSeq \| MGI Sequence Detail	2260	ZRU/MplStud
polypeptide	Q00322	UniProt \| EBI \| MGI Sequence Detail	268	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000005309 CCAAT/enhancer-binding protein delta

(term hierarchy)
InterPro Domains

IPR004827 Basic-leucine zipper domain

IPR046347 Basic-leucine zipper domain superfamily

IPR031106 CCAAT/enhancer-binding protein C/EBP

IPR016468 CCAAT/enhancer-binding protein, chordates

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All nucleic 55

Genomic 5

cDNA 42

Primer pair 5

Other 3

Microarray probesets 5

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MGD-MRK-24458

Summaries

All 145

Developmental Gene Expression 25

Gene Ontology 15

Phenotypes 39
Earliest

J:23758 Cao Z, et al., Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells. Genes Dev. 1991 Sep;5(9):1538-52
Latest

J:341717 Taylor TC, et al., IkappaBzeta is an essential mediator of immunity to oropharyngeal candidiasis. Cell Host Microbe. 2023 Oct 11;31(10):1700-1713.e4

TSS for Cebpd:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr137226	Chr16:15705142-15705156 (+)	-1 bp
Tssr137227	Chr16:15705312-15705325 (+)	169 bp
Tssr137228	Chr16:15705640-15705664 (+)	502 bp
Tssr137229	Chr16:15705999-15706016 (+)	858 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24