Apoh MGI Mouse Gene Detail - MGI:88058

Symbol

Apoh
Name

apolipoprotein H
Synonyms

B2GPI, beta-2-glycoprotein 1, beta-2-GPI

Feature Type

protein coding gene
IDs

MGI:88058
NCBI Gene: 11818
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr11:108286123-108305222 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 71.80 cM, cytoband D
Mapping Data

6 experiments

SNPs within 2kb

472 from dbSNP Build 142
Strain Annotations

18
PCR

1
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_88058	protein coding gene	Chr11:108234180-108305222 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019326	protein coding gene	Chr11:111809497-111881919 (+)
A/J	MGP_AJ_G0019294	protein coding gene	Chr11:106998406-107061406 (+)
AKR/J	MGP_AKRJ_G0019263	protein coding gene	Chr11:110198911-110270885 (+)
BALB/cJ	MGP_BALBcJ_G0019268	protein coding gene	Chr11:107429141-107491317 (+)
C3H/HeJ	MGP_C3HHeJ_G0019077	protein coding gene	Chr11:110515287-110582311 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019718	protein coding gene	Chr11:115216087-115290345 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017342	protein coding gene	Chr11:104263924-104325373 (+)
CAST/EiJ	MGP_CASTEiJ_G0018630	protein coding gene	Chr11:111624519-111694228 (+)
CBA/J	MGP_CBAJ_G0019046	protein coding gene	Chr11:119999915-120068398 (+)
DBA/2J	MGP_DBA2J_G0019158	protein coding gene	Chr11:106476652-106549239 (+)
FVB/NJ	MGP_FVBNJ_G0019149	protein coding gene	Chr11:105983753-106046229 (+)
LP/J	MGP_LPJ_G0019228	protein coding gene	Chr11:112240989-112316256 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019179	protein coding gene	Chr11:119180261-119251040 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019755	protein coding gene	Chr11:110764816-110835983 (+)
PWK/PhJ	MGP_PWKPhJ_G0018395	protein coding gene	Chr11:107634781-107699132 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018186	protein coding gene	Chr11:110510899-110584402 (+)
WSB/EiJ	MGP_WSBEiJ_G0018681	protein coding gene	Chr11:110697628-110767753 (+)

Human Ortholog

APOH, apolipoprotein H

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

APOH, apolipoprotein H
Synonyms

B2G1, B2GP1, BG
Links

HGNC:616

NCBI Gene ID: 350

neXtProt AC: NX_P02749

UniProt: P02749
Chr Location

17q24.2; chr17:66212033-66256525 (-) GRCh38

MGI Vertebrate Homology

Apoh stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: APOH
Gene Tree

Apoh

Diseases

3 with human APOH associations

				Human Disease	Mouse Models
				antiphospholipid syndrome IDs antiphospholipid syndrome DOID:2988 ICD10CM:D68.61 MESH:D016736 NCI:C61283 OMIM:107320 UMLS_CUI:C0085278
				myocardial infarction IDs myocardial infarction DOID:5844 EFO:0000612 ICD10CM:I21 MESH:D009203 NCI:C27996 OMIM:608557 UMLS_CUI:C0027051
				peripheral vascular disease IDs peripheral vascular disease DOID:341 DOID:2868 ICD9CM:443.81 MESH:D001157 UMLS_CUI:C0003838 UMLS_CUI:C0031115

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Endonuclease-mediated

3
Targeted

3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

23 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mutation of this gene results in reduced viability and reduced thrombin production. Only 8% homozygous null animals are born from heterozygous intercrosses.

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All GO Annotations

49
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

795
Tissues

10
cDNA Data

187
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase apoh

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All Sequences

49
RefSeq

4
UniProt

5
CCDS

CCDS25574.1

Ensembl

ENSMUSG00000000049 (Evidence)
NCBI Gene

11818

			Length	Strain/Species	Flank
genomic	11818	NCBI Gene Model \| MGI Sequence Detail	19100	C57BL/6J	± kb
transcript	NM_013475	RefSeq \| MGI Sequence Detail	1202	ZRU/MplStud
polypeptide	Q01339	UniProt \| EBI \| MGI Sequence Detail	345	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000004157 beta-2-glycoprotein 1

(term hierarchy)
InterPro Domains

IPR015104 Beta-2-glycoprotein-1 fifth domain

IPR050350 Complement & Cell Adhesion Regulators

IPR000436 Sushi/SCR/CCP domain

IPR035976 Sushi/SCR/CCP superfamily
GlyGen

Q01339 7 sites, 5 N-linked glycans (3 sites), 1 O-linked glycan (1 site)

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All nucleic 193

Genomic 1

cDNA 188

Primer pair 3

Other 1

Microarray probesets 5

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MGD-MRK-1377

Summaries

All 45

Developmental Gene Expression 5

Gene Ontology 5

Phenotypes 12
Earliest

J:1723 Nonaka M, et al., Molecular cloning of mouse beta 2-glycoprotein I and mapping of the gene to chromosome 11. Genomics. 1992 Aug;13(4):1082-7
Latest

J:354301 Phinney NZ, et al., Development of betabodies: The next generation of phosphatidylserine targeting agents. J Biol Chem. 2024 Aug 17;300(9):107681

TSS for Apoh:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr105604	Chr11:108286114-108286150 (+)	9 bp
Tssr105605	Chr11:108286702-108286724 (+)	590 bp
Tssr105606	Chr11:108286752-108286777 (+)	642 bp
Tssr105607	Chr11:108295639-108295654 (+)	9,524 bp
Tssr105608	Chr11:108298106-108298133 (+)	11,997 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 10/29/2024 MGI 6.24