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Mtf2 Gene Detail
Summary
  • Symbol
    Mtf2
  • Name
    metal response element binding transcription factor 2
  • Synonyms
    9230112N11Rik, C76717, M96, Pcl2
  • Feature Type
    protein coding gene
  • IDs
    MGI:105050
    NCBI Gene: 17765
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:108213540-108256870 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 52.41 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    884 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_105050
 protein coding gene Chr5:108213518-108257085 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029849
 protein coding gene Chr5:110132792-110176254 (+)
A/J MGP_AJ_G0029813
 protein coding gene Chr5:105913752-105957464 (+)
AKR/J MGP_AKRJ_G0029758
 protein coding gene Chr5:109323384-109367894 (+)
BALB/cJ MGP_BALBcJ_G0029825
 protein coding gene Chr5:107050439-107093706 (+)
C3H/HeJ MGP_C3HHeJ_G0029547
 protein coding gene Chr5:109791209-109838720 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030279
 protein coding gene Chr5:114636006-114680713 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027513
 protein coding gene Chr5:100963473-101005895 (+)
CAST/EiJ MGP_CASTEiJ_G0028961
 protein coding gene Chr5:108713487-108758094 (+)
CBA/J MGP_CBAJ_G0029515
 protein coding gene Chr5:118505657-118557475 (+)
DBA/2J MGP_DBA2J_G0029661
 protein coding gene Chr5:106042424-106085664 (+)
FVB/NJ MGP_FVBNJ_G0029618
 protein coding gene Chr5:104770199-104813850 (+)
LP/J MGP_LPJ_G0029749
 protein coding gene Chr5:110727253-110771115 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029650
 protein coding gene Chr5:123402158-123449823 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030313
 protein coding gene Chr5:108891358-108938350 (+)
PWK/PhJ MGP_PWKPhJ_G0028674
 protein coding gene Chr5:104856551-104901569 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028512
 protein coding gene Chr5:106411414-106456455 (+)
WSB/EiJ MGP_WSBEiJ_G0029034
 protein coding gene Chr5:109189052-109237228 (+)



Homology
more
  • Human Ortholog
    MTF2, metal response element binding transcription factor 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MTF2, metal response element binding transcription factor 2
  • Synonyms
    dJ976O13.2, M96, PCL2, TDRD19A
  • Links
    NCBI Gene ID: 22823
    neXtProt AC: NX_Q9Y483
    UniProt: Q9Y483

  • Chr Location
    1p22.1; chr1:93079235-93139079 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotypes from 3 alleles in 4 genetic backgrounds
    13 phenotypes from multigenic genotypes
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit vertebral transformation and delayed replicative senescence in MEFs. Mice homozygous for one gene trap allele exhibit postnatal lethality, vertebral transformation and delayed replicative senescence in MEFs.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    24
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1017
  • Tissues
    210
  • cDNA Data
    33
  • Literature Summary
    12
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000029267 Ensembl Gene Model | MGI Sequence Detail 43331 C57BL/6J ±  kb
    transcript ENSMUST00000081567 Ensembl | MGI Sequence Detail 4060 Not Applicable  
    polypeptide ENSMUSP00000080278 Ensembl | MGI Sequence Detail 593 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 38
      Genomic 1
      cDNA 33
      Primer pair 3
      Other 1

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGD-MRK-32089, MGI:1924995, MGI:2141276, MGI:3034211
    References
    more
    • Summaries
      All 66
      Developmental Gene Expression 12
      Gene Ontology 10
      Phenotypes 18
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:313619 Bedogni F, et al., Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory