Eif2ak2 MGI Mouse Gene Detail - MGI:1353449 - eukaryotic translation initiation factor 2-alpha kinase 2

Symbol

Eif2ak2
Name

eukaryotic translation initiation factor 2-alpha kinase 2
Synonyms

2310047A08Rik, 4732414G15Rik, dsRNA-activated kinase, eIF-2 alpha, eIF-2 alpha, IFN-induced and double-stranded RNA-activated kinase, IFN- type I-induced and dsRNA-activated kinase, Pkr, Prkr, Tik

Feature Type

protein coding gene
IDs

MGI:1353449
NCBI Gene: 19106
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr17:79159993-79190002 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 49.56 cM, cytoband E2
Mapping Data

14 experiments

SNPs within 2kb

834 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1353449	protein coding gene	Chr17:79157933-79190002 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0024043	protein coding gene	Chr17:81687566-81720040 (-)
A/J	MGP_AJ_G0024000	protein coding gene	Chr17:79188990-79219266 (-)
AKR/J	MGP_AKRJ_G0023969	protein coding gene	Chr17:80388515-80422618 (-)
BALB/cJ	MGP_BALBcJ_G0024002	protein coding gene	Chr17:79052159-79088178 (-)
C3H/HeJ	MGP_C3HHeJ_G0023766	protein coding gene	Chr17:81293996-81325784 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0024446	protein coding gene	Chr17:84669649-84701328 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021889	protein coding gene	Chr17:74582280-74612575 (-)
CAST/EiJ	MGP_CASTEiJ_G0023246	protein coding gene	Chr17:81898163-81931429 (-)
CBA/J	MGP_CBAJ_G0023740	protein coding gene	Chr17:88200418-88232686 (-)
DBA/2J	MGP_DBA2J_G0023869	protein coding gene	Chr17:77706711-77736584 (-)
FVB/NJ	MGP_FVBNJ_G0023835	protein coding gene	Chr17:77224710-77255155 (-)
LP/J	MGP_LPJ_G0023952	protein coding gene	Chr17:82536843-82568752 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023863	protein coding gene	Chr17:88320293-88355759 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024491	protein coding gene	Chr17:80866645-80899978 (-)
PWK/PhJ	MGP_PWKPhJ_G0022992	protein coding gene	Chr17:77201732-77233621 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0022803	protein coding gene	Chr17:77659700-77687191 (-)
WSB/EiJ	MGP_WSBEiJ_G0023313	protein coding gene	Chr17:81682597-81715588 (-)

Human Ortholog

EIF2AK2, eukaryotic translation initiation factor 2 alpha kinase 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

EIF2AK2, eukaryotic translation initiation factor 2 alpha kinase 2
Synonyms

DYT33, EIF2AK1, LEUDEN, PKR, PPP1R83, PRKR
Links

HGNC:9437

NCBI Gene ID: 5610

neXtProt AC: NX_P19525

UniProt: P19525
Chr Location

2p22.2; chr2:37099210-37157522 (-) GRCh38

MGI Vertebrate Homology

Eif2ak2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: EIF2AK2
Protein SuperFamily

Integrin-linked_kinase
Gene Tree

Eif2ak2

Diseases

5 with human EIF2AK2 associations

				Human Disease	Mouse Models
				Alzheimer's disease IDs Alzheimer's disease DOID:10652 ICD10CM:G30 ICD9CM:331.0 KEGG:05010 MESH:D000544 NCI:C2866 UMLS_CUI:C0002395
				dystonia 33 IDs dystonia 33 DOID:0060940 OMIM:619687
				hepatitis B IDs hepatitis B DOID:2043 DOID:12591 DOID:12592 DOID:2042 EFO:0004197 MESH:D006509 NCI:C3097 UMLS_CUI:C0019163
				Huntington's disease IDs Huntington's disease DOID:12858 ICD10CM:G10 ICD9CM_2006:333.4 ICD9CM:333.4 KEGG:05016 MESH:D006816 NCI:C82342 OMIM:143100 UMLS_CUI:C0020179
				Parkinson's disease IDs Parkinson's disease DOID:14330 ICD10CM:G20 ICD9CM:332 ICD9CM:332.0 KEGG:05012 MESH:D010300 NCI:C26845 OMIM:PS168600 ORDO:2828 UMLS_CUI:C0030567

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

19 phenotypes from 4 alleles in 5 genetic backgrounds
13 phenotypes from multigenic genotypes
93 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

16
Endonuclease-mediated

7
Gene trapped

4
Targeted

5
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

41 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for disruptions in this gene display altered susceptibility to viral infection.

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All GO Annotations

71
GO References

23

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

752
Tissues

39
cDNA Data

38
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase eif2ak2

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All Sequences

60
RefSeq

4
UniProt

3
CCDS

CCDS28980.1

Ensembl

ENSMUSG00000024079 (Evidence)
NCBI Gene

19106

			Length	Strain/Species	Flank
genomic	ENSMUSG00000024079	Ensembl Gene Model \| MGI Sequence Detail	30010	C57BL/6J	± kb
transcript	ENSMUST00000024884	Ensembl \| MGI Sequence Detail	4313	Not Applicable
polypeptide	ENSMUSP00000024884	Ensembl \| MGI Sequence Detail	515	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000006959 interferon-induced, double-stranded RNA-activated protein kinase

(term hierarchy)
PDB

1X48, 1X49
EC

2.7.10.2, 2.7.11.1
InterPro Domains

IPR050339 Cell Cycle and Stress Response Kinase

IPR014720 Double-stranded RNA-binding domain

IPR044452 EIF2AK2, first double-stranded RNA binding domain

IPR044453 EIF2AK2, second double-stranded RNA binding domain

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR008271 Serine/threonine-protein kinase, active site
GlyGen

Q03963 1 site, 1 O-linked glycan (1 site)

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All nucleic 47

Genomic 6

cDNA 38

Primer pair 3

Microarray probesets 5

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MGD-MRK-13612, MGD-MRK-15108, MGI:1924009, MGI:2146878, MGI:2146919, MGI:97761, MGI:98750

Summaries

All 192

Developmental Gene Expression 6

Gene Ontology 23

Phenotypes 93
Earliest

J:43390 Icely PL, et al., TIK, a novel serine/threonine kinase, is recognized by antibodies directed against phosphotyrosine. J Biol Chem. 1991 Aug 25;266(24):16073-7
Latest

J:354587 Nedomova M, et al., DDI2 protease controls embryonic development and inflammation via TCF11/NRF1. iScience. 2024 Oct 18;27(10):110893

TSS for Eif2ak2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr149421	Chr17:79190003-79190012 (-)	-6 bp
Tssr149420	Chr17:79189937-79189983 (-)	42 bp
Tssr149419	Chr17:79184694-79184722 (-)	5,294 bp
Tssr149418	Chr17:79177906-79177920 (-)	12,089 bp
Tssr149417	Chr17:79166136-79166142 (-)	23,863 bp
Tssr149416	Chr17:79164039-79164055 (-)	25,955 bp
Tssr149415	Chr17:79162499-79162510 (-)	27,497 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 10/29/2024 MGI 6.24