Cxcr5 MGI Mouse Gene Detail - MGI:103567 - C-X-C motif chemokine receptor 5

Symbol

Cxcr5
Name

C-X-C motif chemokine receptor 5
Synonyms

Blr1, CXCR-5, Gpcr6

Feature Type

protein coding gene
IDs

MGI:103567
NCBI Gene: 12145
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr9:44423084-44437741 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 24.84 cM
Mapping Data

3 experiments

SNPs within 2kb

369 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_103567	protein coding gene	Chr9:44423084-44473174 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0034713	protein coding gene	Chr9:43007477-43052567 (-)
A/J	MGP_AJ_G0034694	protein coding gene	Chr9:41804030-41848956 (-)
AKR/J	MGP_AKRJ_G0034621	protein coding gene	Chr9:42673447-42723470 (-)
BALB/cJ	MGP_BALBcJ_G0034685	protein coding gene	Chr9:41551689-41596040 (-)
C3H/HeJ	MGP_C3HHeJ_G0034396	protein coding gene	Chr9:43127960-43174902 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0035206	protein coding gene	Chr9:44279301-44326121 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032121	protein coding gene	Chr9:41388298-41428885 (-)
CAST/EiJ	MGP_CASTEiJ_G0033718	protein coding gene	Chr9:42975316-43023662 (-)
CBA/J	MGP_CBAJ_G0034368	protein coding gene	Chr9:45898822-45947327 (-)
DBA/2J	MGP_DBA2J_G0034527	protein coding gene	Chr9:41706866-41755767 (-)
FVB/NJ	MGP_FVBNJ_G0034468	protein coding gene	Chr9:40967845-40983023 (-)
LP/J	MGP_LPJ_G0034608	protein coding gene	Chr9:43307884-43358479 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0034512	protein coding gene	Chr9:47726795-47775056 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035227	protein coding gene	Chr9:42575159-42625704 (-)
PWK/PhJ	MGP_PWKPhJ_G0033424	protein coding gene	Chr9:41588348-41634139 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0033258	protein coding gene	Chr9:42891647-42937364 (-)
WSB/EiJ	MGP_WSBEiJ_G0033831	protein coding gene	Chr9:42609994-42660679 (-)

Human Ortholog

CXCR5, C-X-C motif chemokine receptor 5

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CXCR5, C-X-C motif chemokine receptor 5
Synonyms

BLR1, CD185, MDR15
Links

HGNC:1060

NCBI Gene ID: 643

neXtProt AC: NX_P32302

UniProt: P32302
Chr Location

11q23.3; chr11:118883892-118897787 (+) GRCh38

MGI Vertebrate Homology

Cxcr5 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: CXCR5
Gene Tree

Cxcr5

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Phenotype Summary

18 phenotypes from 2 alleles in 3 genetic backgrounds
1 phenotype from multigenic genotypes
106 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

16
Endonuclease-mediated

8
Targeted

6
Transgenic

2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

28 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Homozygous null mutants lack inguinal lymph nodes, have a few abnormal or no Peyer's patches, morphologically altered primary lymphoid follicles and no functional germinal centers in their spleen.

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All GO Annotations

16
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

756
Tissues

35
cDNA Data

11
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA CXCR5

Xenbase cxcr5

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All Sequences

45
RefSeq

2
UniProt

3
CCDS

CCDS23115.1

Ensembl

ENSMUSG00000047880 (Evidence)
NCBI Gene

12145

			Length	Strain/Species	Flank
genomic	12145	NCBI Gene Model \| MGI Sequence Detail	14658	C57BL/6J	± kb
transcript	NM_007551	RefSeq \| MGI Sequence Detail	2659	ZRU/MplStud
polypeptide	Q04683	UniProt \| EBI \| MGI Sequence Detail	374	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000001209 C-X-C chemokine receptor type 5

(term hierarchy)
InterPro Domains

IPR001053 CXC chemokine receptor 5

IPR017452 GPCR, rhodopsin-like, 7TM

IPR050119 G-protein coupled receptor 1

IPR000276 G protein-coupled receptor, rhodopsin-like
GlyGen

Q04683 2 sites

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All nucleic 20

Genomic 6

cDNA 11

Primer pair 2

Other 1

Microarray probesets 4

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MGD-MRK-16340, MGD-MRK-24452, MGI:99562

Summaries

All 153

Developmental Gene Expression 6

Gene Ontology 9

Phenotypes 106
Earliest

J:15563 Wilkie TM, et al., Identification, chromosomal location, and genome organization of mammalian G-protein-coupled receptors. Genomics. 1993 Nov;18(2):175-84
Latest

J:354960 Chang Y, et al., TGF-beta specifies T(FH) versus T(H)17 cell fates in murine CD4(+) T cells through c-Maf. Sci Immunol. 2024 Mar;9(93):eadd4818

TSS for Cxcr5:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr89171	Chr9:44437801-44437812 (-)	-66 bp
Tssr89170	Chr9:44437766-44437798 (-)	-41 bp
Tssr89169	Chr9:44437721-44437737 (-)	12 bp
Tssr89168	Chr9:44437694-44437720 (-)	34 bp
Tssr89167	Chr9:44437265-44437269 (-)	474 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/05/2024 MGI 6.24