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Cdk16 Gene Detail
Summary
  • Symbol
    Cdk16
  • Name
    cyclin dependent kinase 16
  • Synonyms
    Crk5, Pctaire1, Pctk1
  • Feature Type
    protein coding gene
  • IDs
    MGI:97516
    NCBI Gene: 18555
  • Alliance
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:20554210-20566119 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome X, 16.18 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    220 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97516
protein coding gene ChrX:20554193-20566119 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035595
protein coding gene ChrX:15575360-15587286 (+)
A/J MGP_AJ_G0035572
protein coding gene ChrX:15666204-15678744 (+)
AKR/J MGP_AKRJ_G0035505
protein coding gene ChrX:16210362-16222288 (+)
BALB/cJ MGP_BALBcJ_G0035565
protein coding gene ChrX:15412217-15424143 (+)
C3H/HeJ MGP_C3HHeJ_G0035283
protein coding gene ChrX:15798134-15810060 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036101
protein coding gene ChrX:15987163-15999927 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032965
protein coding gene ChrX:13915952-13928061 (+)
CAST/EiJ MGP_CASTEiJ_G0034574
protein coding gene ChrX:15090246-15102148 (+)
CBA/J MGP_CBAJ_G0035252
protein coding gene ChrX:16722108-16734034 (+)
DBA/2J MGP_DBA2J_G0035404
protein coding gene ChrX:15468851-15480777 (+)
FVB/NJ MGP_FVBNJ_G0035350
protein coding gene ChrX:15369806-15381732 (+)
LP/J MGP_LPJ_G0035486
protein coding gene ChrX:15827327-15839265 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035394
protein coding gene ChrX:16979093-16991019 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036108
protein coding gene ChrX:15495246-15507172 (+)
PWK/PhJ MGP_PWKPhJ_G0034275
protein coding gene ChrX:14657020-14668985 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034115
protein coding gene ChrX:15475785-15488834 (+)
WSB/EiJ MGP_WSBEiJ_G0034709
protein coding gene ChrX:15359468-15371398 (+)



Homology
more
  • Human Ortholog
    CDK16, cyclin dependent kinase 16
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CDK16, cyclin dependent kinase 16
  • Synonyms
    PCTAIRE, PCTAIRE1, PCTGAIRE, PCTK1
  • Links
    NCBI Gene ID: 5127
    neXtProt AC: NX_Q00536
    UniProt: Q00536

  • Chr Location
    Xp11.3; chrX:47217860-47229997 (+)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit male infertility associated with asthenozoospermia and abnormal sperm morphology.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18555 NCBI Gene Model | MGI Sequence Detail 11910 C57BL/6J ±  kb
    transcript NM_001411707 RefSeq | MGI Sequence Detail 3256 ZRU/MplStud  
    polypeptide Q04735 UniProt | EBI | MGI Sequence Detail 496 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 24
      cDNA 21
      Primer pair 3

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-13196, MGD-MRK-2149, MGI:88506
    References
    more
    • Summaries
      All 53
      Developmental Gene Expression 8
      Gene Ontology 15
      Phenotypes 10
    • Earliest
      J:3108 Okuda T, et al., PCTAIRE-1 and PCTAIRE-3, two members of a novel cdc2/CDC28-related protein kinase gene family. Oncogene. 1992 Nov;7(11):2249-58
    • Latest
      J:325355 Rong Y, et al., USP16-mediated histone H2A lysine-119 deubiquitination during oocyte maturation is a prerequisite for zygotic genome activation. Nucleic Acids Res. 2022 Jun 10;50(10):5599-5616

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    last database update
    11/19/2024
    MGI 6.24
    The Jackson Laboratory