Apoc2 MGI Mouse Gene Detail - MGI:88054

Symbol

Apoc2
Name

apolipoprotein C2

Feature Type

protein coding gene
IDs

MGI:88054
NCBI Gene: 11813
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr7:19405504-19411866 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 9.94 cM
Mapping Data

6 experiments

SNPs within 2kb

293 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_88054	protein coding gene	Chr7:19405504-19411866 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0031789	protein coding gene	Chr7:17711938-17721164 (-)
A/J	MGP_AJ_G0031765	protein coding gene	Chr7:17321205-17331193 (-)
AKR/J	MGP_AKRJ_G0031691	protein coding gene	Chr7:17800309-17811212 (-)
BALB/cJ	MGP_BALBcJ_G0031770	protein coding gene	Chr7:17527785-17536446 (-)
C3H/HeJ	MGP_C3HHeJ_G0031492	protein coding gene	Chr7:18067193-18076118 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0032236	protein coding gene	Chr7:18577328-18589037 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0029302	protein coding gene	Chr7:18971125-18981262 (-)
CAST/EiJ	MGP_CASTEiJ_G0030835	protein coding gene	Chr7:14503550-14512535 (-)
CBA/J	MGP_CBAJ_G0031454	protein coding gene	Chr7:19260749-19269864 (-)
DBA/2J	MGP_DBA2J_G0031609	protein coding gene	Chr7:17272998-17284841 (-)
FVB/NJ	MGP_FVBNJ_G0031561	protein coding gene	Chr7:17142976-17153415 (-)
LP/J	MGP_LPJ_G0031692	protein coding gene	Chr7:18023310-18032787 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0031597	protein coding gene	Chr7:19085061-19093894 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0032264	protein coding gene	Chr7:17412618-17423829 (-)
PWK/PhJ	MGP_PWKPhJ_G0030559	protein coding gene	Chr7:14371109-14382647 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0030386	protein coding gene	Chr7:12122731-12131573 (-)
WSB/EiJ	MGP_WSBEiJ_G0030935	protein coding gene	Chr7:17629798-17640064 (-)

Human Ortholog

APOC2, apolipoprotein C2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

APOC2, apolipoprotein C2
Synonyms

APO-CII, APOC-II
Links

HGNC:609

NCBI Gene ID: 344

neXtProt AC: NX_P02655

UniProt: P02655
Chr Location

19q13.32; chr19:44946035-44949565 (+) GRCh38

MGI Vertebrate Homology

Apoc2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: APOC2
Gene Tree

Apoc2

Diseases

3 with human APOC2 associations

				Human Disease	Mouse Models
				familial apolipoprotein C-II deficiency IDs familial apolipoprotein C-II deficiency DOID:0111418 MESH:D008072 OMIM:207750 ORDO:309020 UMLS_CUI:C0268199 UMLS_CUI:C1720779
				familial hyperlipidemia IDs familial hyperlipidemia DOID:1168 DOID:3147 ICD10CM:E78.5 MESH:D006949 MESH:D006951 NCI:C34707 NCI:C34709 UMLS_CUI:C0020473 UMLS_CUI:C0020476
				multiple sclerosis IDs multiple sclerosis DOID:2377 ICD10CM:G35 ICD9CM:340 MESH:D009103 NCI:C3243 OMIM:612594 OMIM:612595 OMIM:612596 UMLS_CUI:C0026769

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

7 phenotypes from 2 alleles in 2 genetic backgrounds
4 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Endonuclease-mediated

2
Targeted

2
Genomic Mutations

2 involving Apoc2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

5 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for an endonuclease-mediated allele exhibit increased circulating triglyceride, decreased circulating HDL cholesterol, and abnormal lipoprotein levels. Mice heterozygous for the allele exhibit an intermediate phenotype.

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All GO Annotations

61
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

908
Tissues

61
cDNA Data

97
Literature Summary

17

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase apoc2

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All Sequences

42
RefSeq

4
UniProt

1
CCDS

CCDS39801.1

Ensembl

ENSMUSG00000002992 (Evidence)
NCBI Gene

11813

			Length	Strain/Species	Flank
genomic	11813	NCBI Gene Model \| MGI Sequence Detail	6363	C57BL/6J	± kb
transcript	NM_001277944	RefSeq \| MGI Sequence Detail	727	ZRU/MplStud
polypeptide	Q05020	UniProt \| EBI \| MGI Sequence Detail	97	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000004151 apolipoprotein C-II

(term hierarchy)
GlyGen

Q05020 1 site, 1 O-linked glycan (1 site)

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All nucleic 114

Genomic 1

cDNA 103

Primer pair 8

Other 2

Microarray probesets 3

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MGD-MRK-1373

Summaries

All 50

Developmental Gene Expression 17

Gene Ontology 5

Phenotypes 4
Earliest

J:24996 Mahley RW, et al., Plasma lipoproteins: apolipoprotein structure and function. J Lipid Res. 1984 Dec 1;25(12):1277-94
Latest

J:347607 Benzow K, et al., Gene replacement-Alzheimer's disease (GR-AD): Modeling the genetics of human dementias in mice. Alzheimers Dement. 2024 Apr;20(4):3080-3087

TSS for Apoc2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr70962	Chr7:19411872-19411877 (-)	-9 bp
Tssr70961	Chr7:19410945-19410957 (-)	915 bp
Tssr70960	Chr7:19410749-19410791 (-)	1,096 bp
Tssr70959	Chr7:19410707-19410725 (-)	1,150 bp
Tssr70958	Chr7:19410674-19410692 (-)	1,183 bp
Tssr70957	Chr7:19409825-19409930 (-)	1,988 bp
Tssr70956	Chr7:19407513-19407525 (-)	4,347 bp
Tssr70955	Chr7:19405754-19405775 (-)	6,101 bp
Tssr70954	Chr7:19405714-19405753 (-)	6,132 bp
Tssr70953	Chr7:19405618-19405628 (-)	6,243 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24