About   Help   FAQ
Ptgs2 Gene Detail
Summary
  • Symbol
    Ptgs2
  • Name
    prostaglandin-endoperoxide synthase 2
  • Synonyms
    Cox-2, COX2, cyclooxygenase 2, cyclooxygenase-2, Pghs2, PGHS-2, PHS-2, prostaglandin G/H synthase, Tis10
  • Feature Type
    protein coding gene
  • IDs
    MGI:97798
    NCBI Gene: 19225
  • Alliance
  • Transcription Start Sites
    98 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:149975851-149983978 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 1, 63.84 cM, cytoband H1
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    251 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97798
protein coding gene Chr1:149975782-149983978 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016572
protein coding gene Chr1:154740570-154750088 (+)
A/J MGP_AJ_G0016555
protein coding gene Chr1:148484211-148492398 (+)
AKR/J MGP_AKRJ_G0016520
protein coding gene Chr1:153014363-153022561 (+)
BALB/cJ MGP_BALBcJ_G0016515
protein coding gene Chr1:149038524-149044490 (+)
C3H/HeJ MGP_C3HHeJ_G0016340
protein coding gene Chr1:153215875-153224249 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016976
protein coding gene Chr1:160079479-160089284 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014685
protein coding gene Chr1:140811873-140819953 (+)
CAST/EiJ MGP_CASTEiJ_G0015919
protein coding gene Chr1:152643515-152652768 (+)
CBA/J MGP_CBAJ_G0016314
protein coding gene Chr1:165765095-165773175 (+)
DBA/2J MGP_DBA2J_G0016420
protein coding gene Chr1:147545652-147554380 (+)
FVB/NJ MGP_FVBNJ_G0016418
protein coding gene Chr1:145985788-145994129 (+)
LP/J MGP_LPJ_G0016491
protein coding gene Chr1:155742553-155750692 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016444
protein coding gene Chr1:173453468-173462398 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017012
protein coding gene Chr1:152838040-152846222 (+)
PWK/PhJ MGP_PWKPhJ_G0015705
protein coding gene Chr1:146477487-146486875 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015492
protein coding gene Chr1:151538752-151556977 (+)
WSB/EiJ MGP_WSBEiJ_G0015982
protein coding gene Chr1:152938844-152947301 (+)



Homology
more
  • Human Ortholog
    PTGS2, prostaglandin-endoperoxide synthase 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PTGS2, prostaglandin-endoperoxide synthase 2
  • Synonyms
    COX-2, COX2, GRIPGHS, hCox-2, PGG/HS, PGHS-2, PHS-2
  • Links
    NCBI Gene ID: 5743
    neXtProt AC: NX_P35354
    UniProt: P35354

  • Chr Location
    1q31.1; chr1:186671791-186680922 (-)  GRCh38

Human Diseases
more
  • Diseases
    19 with human PTGS2 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    202 phenotypes from 14 alleles in 23 genetic backgrounds
    36 phenotypes from multigenic genotypes
    3 images
    348 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice exhibit increased perinatal mortality associated with frequent lack of closure and remodeling of the ductus arteriosus, background-sensitive kidney dysplasia with microcyst formation, and myocardial fibrosis. Mutant females show impaired fertility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 19225 NCBI Gene Model | MGI Sequence Detail 8128 C57BL/6J ±  kb
    transcript NM_011198 RefSeq | MGI Sequence Detail 4384 ZRU/MplStud  
    polypeptide Q05769 UniProt | EBI | MGI Sequence Detail 604 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 43
      Genomic 6
      cDNA 26
      Primer pair 9
      Other 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-13665
    References
    more
    • Summaries
      All 660
      Developmental Gene Expression 66
      Diseases 1
      Gene Ontology 31
      Phenotypes 348
    • Earliest
      J:9454 Tippetts MT, et al., Tumor promoter-inducible genes are differentially expressed in the developing mouse. Mol Cell Biol. 1988 Oct;8(10):4570-2
    • Latest
      J:350445 Sakurai J, et al., Effects of blastocyst elongation and implantation chamber formation on the alignment of the embryonic axis and uterine axis in mice. Front Cell Dev Biol. 2024;12:1421222

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.
    last database update
    10/22/2024
    MGI 6.24
    The Jackson Laboratory