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Fmn1 Gene Detail
Summary
  • Symbol
    Fmn1
  • Name
    formin 1
  • Synonyms
    Fmn, formin-1, ld, limb deformity
  • Feature Type
    protein coding gene
  • IDs
    MGI:101815
    NCBI Gene: 14260
  • Alliance
    gene page
  • Transcription Start Sites
    28 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:113158081-113547112 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 57.30 cM, cytoband C1-qter
  • Mapping Data
    15 experiments
Strain
Comparison
more
  • SNPs within 2kb
    10193 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
  • RFLP
    15
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_101815
 protein coding gene Chr2:113158029-113547113 (+)
129S1/SvImJ MGP_129S1SvImJ_G0026296
 protein coding gene Chr2:115802466-116192088 (+)
A/J MGP_AJ_G0026257
 protein coding gene Chr2:111069829-111468008 (+)
AKR/J MGP_AKRJ_G0026236
 protein coding gene Chr2:114174685-114567530 (+)
BALB/cJ MGP_BALBcJ_G0026270
 protein coding gene Chr2:111313741-111700488 (+)
C3H/HeJ MGP_C3HHeJ_G0026015
 protein coding gene Chr2:114590594-114991031 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026717
 protein coding gene Chr2:119626521-120041977 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024097
 protein coding gene Chr2:106262980-106634427 (+)
CAST/EiJ MGP_CASTEiJ_G0025478
 protein coding gene Chr2:114871215-115327720 (+)
CBA/J MGP_CBAJ_G0025992
 protein coding gene Chr2:123818724-124239724 (+)
DBA/2J MGP_DBA2J_G0026131
 protein coding gene Chr2:110541711-110922910 (+)
FVB/NJ MGP_FVBNJ_G0026093
 protein coding gene Chr2:109393178-109774004 (+)
LP/J MGP_LPJ_G0026232
 protein coding gene Chr2:116094639-116500125 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026112
 protein coding gene Chr2:128200982-128629072 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026772
 protein coding gene Chr2:114249090-114643171 (+)
PWK/PhJ MGP_PWKPhJ_G0025214
 protein coding gene Chr2:110042009-110433257 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025013
 protein coding gene Chr2:113400392-113828810 (+)
WSB/EiJ MGP_WSBEiJ_G0025547
 protein coding gene Chr2:115061575-115468249 (+)



Homology
more
  • Human Ortholog
    FMN1, formin 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FMN1, formin 1
  • Synonyms
    FMN, LD
  • Links
    NCBI Gene ID: 342184
    neXtProt AC: NX_Q68DA7
    UniProt: Q68DA7

  • Chr Location
    15q13.3; chr15:32765544-33194714 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human FMN1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    22 phenotypes from 7 alleles in 7 genetic backgrounds
    39 phenotypes from multigenic genotypes
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for spontaneous, irradiation-induced, and transgene-insertional mutations show severe syndactyly and oligodactyly of the feet, abnormal long bones (including radius-ulna fusions), and reduced or absent kidneys. Many mutants survive and breed.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    28
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    905
  • Tissues
    64
  • cDNA Data
    65
  • Literature Summary
    18
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000044042 Ensembl Gene Model | MGI Sequence Detail 389032 C57BL/6J ±  kb
    transcript ENSMUST00000102547 Ensembl | MGI Sequence Detail 4967 Not Applicable  
    polypeptide ENSMUSP00000099606 Ensembl | MGI Sequence Detail 1466 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 101
      Genomic 22
      cDNA 67
      Primer pair 8
      Other 4

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-11761, MGD-MRK-18633, MGI:2139439
    References
    more
    • Summaries
      All 88
      Developmental Gene Expression 18
      Gene Ontology 15
      Phenotypes 30
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory