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Sox4 Gene Detail
Summary
  • Symbol
    Sox4
  • Name
    SRY (sex determining region Y)-box 4
  • Synonyms
    Sox-4
  • Feature Type
    protein coding gene
  • IDs
    MGI:98366
    NCBI Gene: 20677
  • Alliance
    gene page
  • Transcription Start Sites
    33 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:29132902-29137682 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 12.87 cM, cytoband A3-A5
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    115 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98366
 protein coding gene Chr13:29132902-29137696 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020409
 protein coding gene Chr13:26740309-26745100 (-)
A/J MGP_AJ_G0020364
 protein coding gene Chr13:26123967-26128747 (-)
AKR/J MGP_AKRJ_G0020341
 protein coding gene Chr13:26621392-26626186 (-)
BALB/cJ MGP_BALBcJ_G0020359
 protein coding gene Chr13:26179782-26184576 (-)
C3H/HeJ MGP_C3HHeJ_G0020162
 protein coding gene Chr13:26664785-26669566 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020795
 protein coding gene Chr13:27689320-27694102 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018386
 protein coding gene Chr13:24536891-24541697 (-)
CAST/EiJ MGP_CASTEiJ_G0019679
 protein coding gene Chr13:26306436-26311223 (-)
CBA/J MGP_CBAJ_G0020118
 protein coding gene Chr13:28882337-28887130 (-)
DBA/2J MGP_DBA2J_G0020240
 protein coding gene Chr13:25636797-25641591 (-)
FVB/NJ MGP_FVBNJ_G0020225
 protein coding gene Chr13:25243343-25248135 (-)
LP/J MGP_LPJ_G0020317
 protein coding gene Chr13:27011650-27016462 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020251
 protein coding gene Chr13:29080736-29085530 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020836
 protein coding gene Chr13:26292305-26297099 (-)
PWK/PhJ MGP_PWKPhJ_G0019434
 protein coding gene Chr13:25768938-25773729 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019255
 protein coding gene Chr13:25187003-25191797 (-)
WSB/EiJ MGP_WSBEiJ_G0019741
 protein coding gene Chr13:26550453-26555245 (-)



Homology
more
  • Human Ortholog
    SOX4, SRY-box transcription factor 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SOX4, SRY-box transcription factor 4
  • Synonyms
    CSS10, EVI16
  • Links
    NCBI Gene ID: 6659
    neXtProt AC: NX_Q06945
    UniProt: Q06945

  • Chr Location
    6p22.3; chr6:21593751-21598619 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human SOX4 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    57 phenotypes from 7 alleles in 10 genetic backgrounds
    86 phenotypes from multigenic genotypes
    1 images
    64 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous targeted null mutants die at embryonic day 14 due to circulatory failure and showing impaired development of the semilunar valves and the muscular ventricular septum. Null fetal liver cells are unable to develop into B-cells in chimeric mice.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    93
  • GO References
    25
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1474
  • Tissues
    444
  • cDNA Data
    22
  • Literature Summary
    110
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20677 NCBI Gene Model | MGI Sequence Detail 4781 C57BL/6J ±  kb
    transcript NM_009238 RefSeq | MGI Sequence Detail 4808 ZRU/MplStud  
    polypeptide Q06831 UniProt | EBI | MGI Sequence Detail 440 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 49
      Genomic 3
      cDNA 26
      Primer pair 13
      Other 7

      Microarray probesets 13
    Other
    Accession IDs
    less
    MGD-MRK-14495, MGD-MRK-14505, MGI:2145172
    References
    more
    • Summaries
      All 205
      Developmental Gene Expression 110
      Gene Ontology 25
      Phenotypes 64
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:350469 Alderman PJ, et al., Delayed maturation and migration of excitatory neurons in the juvenile mouse paralaminar amygdala. Neuron. 2024 Feb 21;112(4):574-592.e10
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory