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Igf2r Gene Detail
Summary
  • Symbol
    Igf2r
  • Name
    insulin-like growth factor 2 receptor
  • Synonyms
    CD222, CI-MPR, IGF-II/CI-MPR, M6P/IGF2R, mannose-6-phosphate receptor, cation independent, Mpr300
  • Feature Type
    protein coding gene
  • IDs
    MGI:96435
    NCBI Gene: 16004
  • Alliance
    gene page
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:12901293-12988551 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 8.64 cM, cytoband A-C
  • Mapping Data
    15 experiments
Strain
Comparison
more
  • SNPs within 2kb
    886 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    3
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96435
 protein coding gene Chr17:12901293-12988593 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023149
 protein coding gene Chr17:10345662-10434593 (-)
A/J MGP_AJ_G0023117
 protein coding gene Chr17:10173927-10267760 (-)
AKR/J MGP_AKRJ_G0023081
 protein coding gene Chr17:10001896-10090752 (-)
BALB/cJ MGP_BALBcJ_G0023117
 protein coding gene Chr17:9950653-10039956 (-)
C3H/HeJ MGP_C3HHeJ_G0022880
 protein coding gene Chr17:10250494-10343007 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023560
 protein coding gene Chr17:10736595-10827295 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021048
 protein coding gene Chr17:4180514-4269837 (+)
CAST/EiJ MGP_CASTEiJ_G0022394
 protein coding gene Chr17:10333027-10424055 (-)
CBA/J MGP_CBAJ_G0022852
 protein coding gene Chr17:11140248-11244468 (-)
DBA/2J MGP_DBA2J_G0022985
 protein coding gene Chr17:9816095-9906259 (-)
FVB/NJ MGP_FVBNJ_G0022955
 protein coding gene Chr17:9756320-9844425 (-)
LP/J MGP_LPJ_G0023057
 protein coding gene Chr17:10163753-10254350 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022974
 protein coding gene Chr17:10744555-10832713 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023586
 protein coding gene Chr17:10273201-10363659 (-)
PWK/PhJ MGP_PWKPhJ_G0022142
 protein coding gene Chr17:9505510-9593771 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021972
 protein coding gene Chr17:9701275-9795302 (-)
WSB/EiJ MGP_WSBEiJ_G0022451
 protein coding gene Chr17:10592392-10679810 (-)



Homology
more
  • Human Ortholog
    IGF2R, insulin like growth factor 2 receptor
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IGF2R, insulin like growth factor 2 receptor
  • Synonyms
    CD222, CI-M6PR, CIMPR, M6P/IGF2R, M6P-R, MPR1, MPR 300, MPR300, MPRI
  • Links
    NCBI Gene ID: 3482
    neXtProt AC: NX_P11717
    UniProt: P11717

  • Chr Location
    6q25.3; chr6:159969082-160113507 (+)  GRCh38
Human Diseases
more
  • Diseases
    6 with human IGF2R associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    73 phenotypes from 7 alleles in 11 genetic backgrounds
    32 phenotypes from multigenic genotypes
    3 images
    34 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mutants inheriting maternally a targeted disruption of this gene exhibit elevated serum and tissue IGF-II levels, overgrowth, organomegaly, kinky tail, polydactyly, heart defects, edema, dyspnea, imperforate vagina, reduced fertility and perinatal death.Survival is influenced by genetic background.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    85
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1296
  • Tissues
    249
  • cDNA Data
    29
  • Literature Summary
    85
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000023830 Ensembl Gene Model | MGI Sequence Detail 87259 C57BL/6J ±  kb
    transcript ENSMUST00000024599 Ensembl | MGI Sequence Detail 8887 Not Applicable  
    polypeptide ENSMUSP00000024599 Ensembl | MGI Sequence Detail 2483 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      9 Sequences
    • Protein Ontology
      PR:000001333 cation-independent mannose-6-phosphate receptor
      (term hierarchy)
    • InterPro Domains
      IPR000479 Cation-independent mannose-6-phosphate receptor repeat
      IPR000562 Fibronectin type II domain
      IPR036943 Fibronectin type II domain superfamily
      IPR013806 Kringle-like fold
      IPR009011 Mannose-6-phosphate receptor binding domain superfamily
      IPR044865 MRH domain
    • GlyGen
      Q07113 23 sites, 17 N-linked glycans (18 sites), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 84
      Genomic 25
      cDNA 33
      Primer pair 21
      Other 5

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-11231, MGI:2146909
    References
    more
    • Summaries
      All 214
      Developmental Gene Expression 85
      Gene Ontology 13
      Phenotypes 34
    • Earliest
      J:9629 Laureys G, et al., Chromosomal mapping of the gene for the type II insulin-like growth factor receptor/cation-independent mannose 6-phosphate receptor in man and mouse. Genomics. 1988 Oct;3(3):224-9
    • Latest
      J:354177 Chen L, et al., IGF2/IGF2R/Sting signaling as a therapeutic target in DSS-induced ulcerative colitis. Eur J Pharmacol. 2023 Dec 5;960:176122
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory