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Acads Gene Detail
Summary
  • Symbol
    Acads
  • Name
    acyl-Coenzyme A dehydrogenase, short chain
  • Synonyms
    Bcd-1, Bcd1, Hdlq8, SCAD
  • Feature Type
    protein coding gene
  • IDs
    MGI:87868
    NCBI Gene: 11409
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:115248358-115257405 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 55.99 cM
  • Mapping Data
    16 experiments
Strain
Comparison
more
  • SNPs within 2kb
    353 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    2
  • RFLP
    14
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_87868
 protein coding gene Chr5:115248358-115257405 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029957
 protein coding gene Chr5:117942419-117952210 (-)
A/J MGP_AJ_G0029922
 protein coding gene Chr5:113268693-113277840 (-)
AKR/J MGP_AKRJ_G0029860
 protein coding gene Chr5:116877950-116887693 (-)
BALB/cJ MGP_BALBcJ_G0029933
 protein coding gene Chr5:114668733-114679386 (-)
C3H/HeJ MGP_C3HHeJ_G0029652
 protein coding gene Chr5:117401334-117412148 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030387
 protein coding gene Chr5:122493722-122502773 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027614
 protein coding gene Chr5:108049263-108057361 (-)
CAST/EiJ MGP_CASTEiJ_G0029061
 protein coding gene Chr5:116322303-116333414 (-)
CBA/J MGP_CBAJ_G0029620
 protein coding gene Chr5:127184449-127193534 (-)
DBA/2J MGP_DBA2J_G0029770
 protein coding gene Chr5:113341810-113351008 (-)
FVB/NJ MGP_FVBNJ_G0029726
 protein coding gene Chr5:112156399-112166560 (-)
LP/J MGP_LPJ_G0029858
 protein coding gene Chr5:118511637-118524169 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029757
 protein coding gene Chr5:131528324-131538805 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030428
 protein coding gene Chr5:116354628-116365256 (-)
PWK/PhJ MGP_PWKPhJ_G0028774
 protein coding gene Chr5:112004475-112016571 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028612
 protein coding gene Chr5:113903622-113912834 (-)
WSB/EiJ MGP_WSBEiJ_G0029136
 protein coding gene Chr5:116938156-116950930 (-)



Homology
more
  • Human Ortholog
    ACADS, acyl-CoA dehydrogenase short chain
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ACADS, acyl-CoA dehydrogenase short chain
  • Synonyms
    ACAD3, SCAD
  • Links
    NCBI Gene ID: 35
    neXtProt AC: NX_P16219
    UniProt: P16219

  • Chr Location
    12q24.31; chr12:120725774-120740008 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Acads mouse models; 2 with human ACADS associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 3 alleles in 2 genetic backgrounds
    4 phenotypes from multigenic genotypes
    38 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display organic aciduria and develop hypoglycemia and fatty livers after fasting.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    28
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    717
  • Tissues
    9
  • cDNA Data
    118
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 11409 NCBI Gene Model | MGI Sequence Detail 9048 C57BL/6J ±  kb
    transcript NM_007383 RefSeq | MGI Sequence Detail 1881 ZRU/MplStud  
    polypeptide Q07417 UniProt | EBI | MGI Sequence Detail 412 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000003602 short-chain specific acyl-CoA dehydrogenase, mitochondrial
      (term hierarchy)
    • EC
      1.3.8.1
    • InterPro Domains
      IPR006089 Acyl-CoA dehydrogenase, conserved site
      IPR036250 Acyl-CoA dehydrogenase-like, C-terminal
      IPR009075 Acyl-CoA dehydrogenase/oxidase, C-terminal
      IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal
      IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain superfamily
      IPR037069 Acyl-CoA dehydrogenase/oxidase, N-terminal domain superfamily
      IPR006091 Acyl-CoA oxidase/dehydrogenase, middle domain
      IPR046373 Acyl-CoA oxidase/dehydrogenase, middle domain superfamily
    • GlyGen
      Q07417 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 123
      Genomic 2
      cDNA 118
      Primer pair 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-1025, MGD-MRK-1517, MGD-MRK-1518, MGI:2140816, MGI:2448341
    References
    more
    • Summaries
      All 89
      Developmental Gene Expression 4
      Diseases 1
      Gene Ontology 9
      Phenotypes 38
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:338257 Peng MZ, et al., Mitochondrial FAD shortage in SLC25A32 deficiency affects folate-mediated one-carbon metabolism. Cell Mol Life Sci. 2022 Jun 21;79(7):375
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory